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Biomedical subjects

G Forsbach

Publications and source records attributed to G Forsbach.

At least 55 records · Page 3Linked to original sources
PubMed1976

Long-acting luteinizing homone-releasing hormone (LH-RH) analogs in the treatment of female infertility.

Induction of ovulation in 20 infertile women was attempted by the use of two synthetic analogs of LH-RH, D-ALA6-Des-Gly10-ethylamide and D-Leu6-Des-Gly10-ethylamide. Ovulation was obtained in five out of the 16 in whom D-Leu6-Des-Gly10-LH-RH ethylamide was administered intramuscularly. Two of the five women received the LH-RH analog additioned of polysaturated gelatines as carrier medium. None of these women got pregnant. It is concluded that better therapeutic results might be expected when a suitable LH-RH vehicle allowing a gradual release of LH-RH analog is obtained.

Adolescent↗
PubMed1976

Clinical use of the LH-RH in assessing gonadotropic reserve in children with idiopathic precocious puberty, premature thelarche and premature adrenarche.

Serum LH and FSH were assayed in 31 girls with normal pre puberty, precocious puberty, premature thelarche, and premature adrenarche, aged 2 to 9 years. The effect of synthetic luteinizing hormone-releasing hormone (LH-RH) on serum gonadotropins was evaluated in eleven of them. In all girls with precocious puberty, serum LH was increased up to high levels. The mean releasable LH in two girls with idiopathic precocious puberty was significantly greater than in normal prepubertal or pubertal children. Basal FSH in children with precocious puberty was within the limits of normal prepuberal children, and FSH secretion in response to LH-RH was not significantly greater than in the group of normal prepubertal and pubertal girls. In children with premature thelarche and premature adrenarche, basal levels of LH and FSH, as well as gonadotropin response to LH-RH were in the prepubertal range. These preliminary results show that the LH-RH test might be of clinical value in differenitating abnormal puberal development.

Age Factors↗
PubMed1976

[Secretion of prolactin in normal anencephalic newborn infants].

Serum prolactin (PRL) was measured by radioimmunoassay in pregnant women at term and in newborns. In 38 newborns of gestational age 39--40 weeks, concentration of PRL in umbilical venous blood was 280.8 +/- 11.2 ng/ml; in maternal venous blood, concentration of PRL was 347.0 +/- 20.1 ng/ml. In the newborn it was found a significant difference in PRL values between both sexes (p less than 0.05), being higher in males than in females (290.0 +/- 14.6 vs. 260.0 +/- 17.1 ng/ml). In three anencephalic infants, PRL ranged from 92.6 to 369.0 ng/ml; 400 mug of thyrotropin-releasing hormone (TRH) administered as bolus injection evoked a rise in PRL in two out of the three, while synthetic luteinizing hormone releasing hormone (LH-RH) elicited no response of FSH secretion. These observations in the fetus and anencephalic infants confirm that the fetus produces high levels of PRL and that this function is independent of any hypothalamic control. The high levels of gestational estrogens seem to be the direct stimulus on the lactotropes to induce synthesis and secretion of PRL. The role of PRL during gestation has not been elucidated.

Anencephaly↗
PubMedDate not supplied

Correlation of optical density, lecithin and lecithin/sphingomyelin ratio in amniotic fluid.

The correlation between optical density at 650 nm, lecithin and lecithin/sphingomyelin ration was investigated in 94 amniotic fluid samples obtained from 90 patients between 28 and 40 weeks of pregnancy. All samples were processed immediately and those contaminated with blood or meconium were discarded. The correlation coefficient between lecithin and absorbance was high (0.926). The lecithin/sphingomyelin ratio also had a good correlation coefficient with the optical density (0.768). We conclude that absorbance at 650 nm is a reliable test for assessing fetal lung maturation.

Amniotic Fluid↗
PubMedDate not supplied

Amenorrhea-galactorrhea associated with Cushing's disease due to pituitary tumor.

Two patients with amenorrhea-galactorrhea and Cushing's disease due to pituitary tumor are presented. In both cases, a diagnosis of prolactin-secreting tumor with moderate hyperprolactinemia was established, then Cushing's disease developed years later. Despite the typical clinical features of Cushing's disease, a dexamethasone suppression test inhibited both blood ACTH and cortisol concentrations in the 2 patients. Hypophysectomy was performed in 1 case, and the histologic study revealed the presence of a cromophobe adenoma. The other case was treated by external radiation which improved the clinical situation. Clinical and endocrinological studies in these 2 cases were compared with previous reports in the literature in order to discuss the etiology of this unusual association. It is concluded that patients with pituitary tumors presenting moderate hyperprolactinemia may also have excessive secretion of ACTH.

Adenoma, Chromophobe↗
PubMedDate not supplied

Reduced dopaminergic inhibition of thyrotropin release in hyperprolactinemic ovulatory women.

It has been suggested that menstrual irregularities in hyperprolactinemia are secondary to an increase in hypothalamic dopaminergic activity via a short loop positive feedback of prolactin (PRL). We have studied this question in a relatively new syndrome characterized by hyperprolactinemia without derangements of the hypothalamic-pituitary-ovarian function due to macroprolactinemia (abnormal high amounts of big-big PRL). Central dopaminergic activity was investigated by the administration of the dopamine antagonist domperidone to normal women (n = 7) and women with anovulatory (n = 6) and ovulatory hyperprolactinemia (n = 2). The effects of domperidone were evaluated in all subjects by the measurements of radioimmunoassayable circulating serum PRL and TSH levels. All subjects had a significant increase in serum PRL levels after 90 min of domperidone administration. Anovulatory hyperprolactinemic subjects showed the highest response to domperidone in terms of TSH, whereas normal women and women with ovulatory hyperprolactinemia had similar increments in TSH serum levels after the administration of the dopamine antagonist. These results support the observation that an increase of hypothalamic dopaminergic activity in hyperprolactinemia may account in part for the presence of menstrual irregularities. The presence of a similar pituitary responsiveness in terms of TSH to domperidone in normal and ovulatory hyperprolactinemic women suggests a similar hypothalamic dopaminergic activity in both group of subjects. These findings might offer an explanation for the coexistence of normal ovulatory cycles in spite of hyperprolactinemia.

Adult↗
PubMedDate not supplied

Radial bone mineral content in healthy Mexican women.

Fifty healthy Mexican women from 21 to 70 years of age volunteered to undergo radial bone densitometry. The bone density in ten women per decade was assessed at two sites in the radius of the nondominant forearm; one site was the distal radius at 5 mm of separation from the ulna and the other at one-third of the distal radius. Calcium, inorganic phosphates and alkaline phosphatase were measured in serum samples and the calcium/creatinine ratio in fasting urine samples. Bone density at the distal radius was 360.6 +/- 36.2 mg/cm2, 369.8 +/- 47.9 mg/cm2 and 364.7 +/- 53.7 mg/cm2 in the 21-50 age group. There was no significant difference between these groups; the pooled value of all these samples was 365 +/- 46 mg/cm2. There was significant difference in the 51-60 age group, 290 +/- 48. mg/cm2 (p less than 0.01) and in the 61-70 age group. 277.9 +/- 49.9 mg/cm2 (p less than 0.01). Bone density at the one-third distal radius in the 21-20 age group was 696.3 +/- 60.9 mg/cm2; 31-40, 683.6 +/- 68.4 mg/cm2 and 41-50, 697.9 +/- 53.9 mg/cm2. There was no significant difference among these group; the pool of all these samples showed 692.6 +/- 59.6 mg/cm2. In the 51-60 age group it was 628.0 +/- 63.3 mg/cm2, a non significant difference. On the other hand, the density in the 61-70 group was 573.7 +/- 83.5 mg/cm2, significant (p less than 0.01) when compared to the 21-50 age group.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗