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Biomedical subjects

G Forche

Publications and source records attributed to G Forche.

At least 19 recordsLinked to original sources
PubMed1986

[Antibacterial therapy of acute exacerbated chronic bronchitis].

An early therapy of the acute exacerbation is important for the long-term prognosis of chronic bronchitis. The aim of the therapy is to stop the progressive damage of the bronchial mucosa. The typical clinical symptoms and the knowledge of the usual pathogens (in at least 80% hemophilus influenzae and streptococcus pneumoniae) allow a "blind" chemotherapy with aminopenicillins, tetracyclines and the trimethoprim-sulphonamide combination as medication of choice. The treatment is successful when the purulent sputum turns mucoid within 2 to 5 days and the symptoms improve. If this does not happen, culture and antibiogram should be made and chemotherapy chosen according to the findings. The acute exacerbation can be complicated by an airway obstruction. In this case the short-term application of glucocorticoids in combination with bronchodilators and secretolytics is suggested.

Anti-Bacterial Agents↗
PubMed1986

[Bronchospasmolytic effectiveness of controlled drug combinations].

Two groups of 10 patients each with a chronic obstructive pulmonary disease were the subjects of a comparative study of the effectiveness of 240 mg theophyllinethylendiamine (Euphyllin) and a combined medication consisting of 25 mg theophyllin, 85 mg etophyllin, 30 mg papaverine and 0.1 mg atropine methylnitrate (Perphyllon). Oscillatory resistance (measured with the Siregnost FD 5) and the circulatory parameters pulse and blood pressure were studied. A statistically significant bronchospasmolytic effect was found for both substances administered parenterally. It was shown, however, that the combined medication worked faster, longer and 4 to 5 times more effectively than theophyllinethylendiamine. The possible causes of the differences are discussed. Clinically, the cardiovascular side effects of the combined medication are to be classified as slight. The tested medication has a favorable therapeutic spectrum as a result of the low dosage of the individual substances.

Airway Resistance↗
PubMed1986

BTPS correction with dynamic spirometers.

In order to determine the requirements for a proper temperature correction of expired volumes, the temperature of the expired air in the bellows of a dynamic spirometer (Vitalograph) was measured in 10 and 5 subjects at 24 and 12.2 degrees C ambient temperature, respectively. During the short period of forced expiration there was a significant temperature decrease, which showed a linear relationship to the ambient temperature. Temperature differences up to 12-15% occurred within seconds; consequently, the values obtained in bellows-type spirometers for FEV1 and FVC have to be corrected to BTPS at room temperature. There was no correlation between the degree of temperature decrease and the magnitude of expiratory volume. For routine clinical work it suffices to use the room temperature as the variable.

Adult↗
PubMed1986

Clinical experience with a bronchospasmolytic aerosol combination.

A comparative study with different bronchospasmolytic inhalers (fenoterol, ipratropium bromide, combination IK-6) was done with ten patients with obstructive airway disease. After a delayed initial effect (owing to the propellant gas) ipratropium bromide showed a bronchospasmolytic effect as good as fenoterol, but without circulatory side effects. The combination with low dosed fenoterol (Berodual) produced equally good subjective and objective results with less side effects than the high dosed fenoterol. These results should form the basis for an optimal long term treatment.

Adult↗
PubMed1986

[First comprehensive spirometric studies of new reference values for unrestricted use].

In contrast to almost all other clinical data, there are as yet no uniform, generally accepted values for spirometric measurements. This is due to technical and organizational problems related to examination procedures. The numerous authors only evaluated data from certain groups of subjects. There has not yet been a uniform study of all age, socioeconomic and occupational groups, urban and rural. Organizational cooperation with a preventive--medicine field study in Styria, together with school examinations, made possible the collection of data from all necessary groups including the basic spirometric values VC, FEV1 and FEV1 %VC. Although strictest epidemiological and methodological exclusion criteria were applied, a very sufficient number of subjects in all groups resulted. All examinations were performed with a half--open dry bellows spirometer. The general validity of the data so obtained is guaranteed as by a study made for this purpose of the cooling behavior of expired air in the spirometer. This data made possible for the first time a statistically acceptable, continuous transition between the model for children and youth on the one hand, and the model for adults on the other. With this large sample, precise statements could be made on the behavior of spirometric values for the growth - period, and the relations of sex, age, height and weight defined. The resulting regression equations can be used without restriction for all relevant problems. The Austrian Standardization Commission has thus already moved to accept these values.

Adolescent↗