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Biomedical subjects

G F Johnson

Publications and source records attributed to G F Johnson.

At least 91 records · Page 5Linked to original sources
PubMed1981

Canine bile duct carcinoma.

Twenty-four adenocarcinomas of the hepatobiliary system were found among 110 primary hepatic neoplasms: 22 of these were intrahepatic, one involved the extrahepatic bile duct and one the gall bladder. Histologically, 10 intrahepatic neoplasms were classified as cholangiocarcinoma, and 12 as bile duct cystadenocarcinoma. The former were characterized by tubular structures lined by anaplastic cuboidal or columnar cells with diffuse fibrous stroma, and the latter by multiple cystic structures with papillary and solid areas. Half the bile duct cystadenocarcinomas showed benign cysts and transition to adenocarcinomas. This was seen in only one case of cholangiocarcinoma. The extrahepatic bile duct carcinoma was characterized by tubular structures lined with flattened cuboidal cells with scant stroma. The gall bladder adenocarcinoma contained many acinar structures lined with columnar or cuboidal cells and separated by thin stroma. Distant metastasis was found in 87.5% (21 of 24) sites of metastasis.

Adenocarcinoma↗
PubMed1981

Canine hepatic carcinoids.

In 110 primary hepatic neoplasms in the dog, 15 carcinoids were diagnosed. Diffuse involvement of all liver lobes with severe hemorrhage and necrosis was seen in all cases. The neoplasms had three distinct histologic patterns: solid nests, cords or ribbons; and an alveolar pattern with rosettes. In all three groups there was fibrovascular stroma that was hyalinized, mineralized, and thick in some places. The neoplastic cells were relatively uniform, polygonal to spindle-shaped, with eosinophilic, granular cytoplasm and vesiculated nuclei. Mitotic activity varied among the three groups. Argyrophilia was seen in all specimens stained with modified Grimelius stain. Metastasis occurred in 14 of 15 dogs (93.3%); the peritoneal wall and adjoining lymph nodes were the most common sites.

Animals↗
PubMed1981

Pediatric Lisfranc injury: "bunk bed" fracture.

A common pediatric fracture is often overlooked due to the subtle deformity of the proximal first metatarsal. The injury is produced during a fall from a height, resulting in a flexion force that wedges the oblique first cuneiform-first metatarsal epiphysis into the first metatarsal-second metatarsal interspace. The injury is more severe than indicated by the bone injury, in that ligaments are involved in subluxation. Anatomic features of the first metatarsal-first cuneiform area present a suitable site for the described injury to occur. The pathogenesis of adult Lisfranc tarsometatarsal dislocation is the model for the pediatric equivalent. The clinical, physical, and radiologic findings of 16 patients are reviewed.

Child↗
PubMed1981

Assessment of tardive dyskinesia in psychiatric outpatients using a standardized rating scale.

Psychiatric outpatients were assessed for dyskinetic movements using the abnormal involuntary movement scale (AIMS). The prevalence of tardive dyskinesia in an Australian sample of 66 patients was 44% which is similar to reported prevalence in other countries. Although the prevalence was significantly higher in patients over 45 years of age and with more than a 5 year history of neuroleptic medication, there were no significant correlations between presence of dyskinesias and age, sex or duration of neuroleptic treatment. Organic factors such as neurological disorders, ECT or alcoholism were not related to dyskinetic movements, nor was the use of anticholinergic or tricyclic antidepressant medication. The AIMS is a reliable rating scale for dyskinetic movements and could be used more widely as a screening instrument for early detection of tardive dyskinesia.

Adolescent↗
PubMed1981

Affective disorders, diabetes mellitus and lithium.

There appears to be an association between affective disorders and diabetes mellitus independent of the use of lithium in treatment. Prior studies have suggested that lithium treatment may impair glucose tolerance or produce frank diabetes in certain patients. Metabolic complications of the diabetic state, such as hyperosmolality and salt depletion increase lithium absorption and the risk of toxicity even at generally acceptable serum levels. The management of patients with diabetes and affective disorders on prophylactic lithium is discussed.

Animals↗
PubMed1980

Canine intestinal adenocarcinoma and carcinoid.

Thirty-one of 35 canine intestinal neoplasms were adenocarcinomas and four were carcinoids. Acinar, solid, papillary and mucinous adenocarcinomas were seen. Acinar and papillary adenocarcinomas were more common the duodenum, colon and rectum. Papillary adenocarcinomas involved longer segments of the intestine. Mucinous adenocarcinomas were in all segments of the intestines but were more frequent in the jejunum. The only signet ring cell carcinoma occurred in the duodenum. Carcinoids occurred equally in the duodenum and colon. Half the rectal tumors showed transition from benign polypoid lesions to adenocarcinomas. Hyperplasia, branching of crypts, increase in goblet cells, and glandular fusion (some cells with anaplasia) were severe in the mucosa adjoining all neoplastic tissue. Local invasion was seen in 32 dogs. Lymph node, lungs, liver and intestinal wall were the most common sites of metastases, Half of the metastases in the liver were from carcinoids and were diffuse.

Adenocarcinoma↗
PubMed1980

The effect of thioridazine on prolactin levels in acutely schizophrenic patients: challenge-dose and steady-state levels.

Prolactin (PRL) levels in unmedicated male patients with acute schizophrenia were within normal range at baseline, increased five fold after a challenge dose of thioridazine, did not significantly increase further after therapeutic dosages, and remained elevated for the duration of treatment. The rise in PRL levels was significantly correlated with the steady-state plasma levels of thioridazine and/or mesoridazine. Baseline and challenge-dose PRL levels did not correlate with severity of symptoms as measured by the Brief Psychiatric Rating Scale, or predict response to thioridazine. Overall, there was a trend for the drug and PRL levels to increase very quickly and remain elevated while the clinical response was gradual over the four-week period. clinically, it may be useful monitoring PRL levels, since the therapeutic dosage should usually be above the dosage required to produce maximal PRL levels.

Acute Disease↗
PubMed1980

Tardive dyskinesia.

Explore the source record for details and available documents.

Dyskinesia, Drug-Induced↗
PubMed1980

Inheritance of copper toxicosis in Bedlington terriers.

The mode of transmission of copper toxicosis, previously reported to be associated with progressive hepatic disease in certain Bedlington Terriers, has been studied by means of 5 matings involving affected and unaffected Bedlington Terriers and dogs of different breeds. The abnormally large concentration of hepatic copper underlying the disorder was found to follow an autosomal recessive pattern of inheritance.

Animals↗
PubMed1980

Enzymic inhibition assay for methotrexate with a discrete analyzer, the ABA-100.

We adapted an inhibition assay for methotrexate, involving dihydrofolate reductase from bovine liver, for use with a discrete analyzer (the ABA-100). The analyzer was used both for dilution and a 5-min pre-incubation of the sample with NADPH--enzyme reagent, and for the assay itself. The standard curve was linear between 10 and 120 microgram/L. Without pre-incubation the standard curve was nonlinear. The presence of albumin in the NADPH--enzyme reagent enhanced both enzyme activity and stability. Within-run precision (CV) was 2.0% (n = 24), run-to-run precision 7.1% (n = 49). Results obtained on patients' samples (29 sera, 15 urines, 18 cerebrospinal fluids) by the present method and a radioimmunoassay method did not differ statistically (p greater than 0.05) when the paired data were analyzed by use of the sign test and Wilcoxon's ranked sign test.

Albumins↗
PubMed1979

Basioccipital clefts.

Two cases of rare basioccipital clefting are reported. In one patient, 10-year follow-up indicates that the radiologic appearance of the clefts does not change with time. Findings in the other case indicate that additional anomalies may occur in adjacent bone structures developing in sequence. A review of the embryological development and discussion of the radiological findings are presented.

Adolescent↗
PubMed1979

Onset of mania in bipolar manic-depressive patients.

Onset of mania was evaluated retrospectively in 48 bipolar manic-depressive patients. Mania occurred as the initial episode in 40% of cases. In patients with initial episode of depression, approximately 80% developed mania prior to their third episodes of depression and within 5 years from the onset of this illness. Differences in type of illness onset were related to family history of bipolar illness and sex of the proband. Male patients with a positive family history were significantly more likely to manifest mania at onset of illness.

Adult↗
PubMed1978

Aglossia-adactylia.

Aglossia-adactylia is part of a family of malformation syndromes in which asymmetric reduction defects of the limbs are associated with oromandibular anomalies. The clinical and radiologic features of six cases are presented. Certain clinical observations, the results of animal studies by other authors, and embryologic considerations suggest a vascular pathogenesis.

Abnormalities, Multiple↗
PubMed1978

Ancestral secondary cases on paternal and maternal sides in bipolar affective illness.

An analysis of the distribution of ancestral secondary cases of affective illness in families of patients with bipolar manicdepressive disorder was undertaken. Twenty probands with at least two affectively ill second degree relatives were available for study. Probands with both parents affected were excluded. The distribution of unilateral to bilateral pairs of all affected relatives, both excluding and including parents, of probands showed no significant differences from that expected in polygenic inheritance. However, separation into bipolar family history, positive or negative, showed significant differences from the expected ratio of unilateral to bilateral pairs in a bipolar family history positive group consistent with a single dominant gene inheritance.

Bipolar Disorder↗