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Biomedical subjects

G Enders

Publications and source records attributed to G Enders.

At least 127 records · Page 7Linked to original sources
PubMed1985

[Connatal varicella embryo-fetopathy].

Connatal varicella embryo-fetopathy is rare. A newborn is described with severe cutaneous lesions, contractures, and hypoplasia of limbs following maternal varicella at the 13th week of pregnancy. Persisting low CF- and ELISA IgG-antibodies up to the age of 18 months give evidence for a prenatal varicella infection. Varicella contact during pregnancy requires rapid serodiagnosis of the immune status; if the women are seronegative, the application of zoster-hyperimmunoglobulin is recommended.

Chickenpox↗
PubMed1984

[Accidental rubella vaccination in pregnancy].

In the Federal Republic of Germany, between 1971 and 1983, 365 women were by chance vaccinated against rubella (Cendehill or RA-27/3-HDC rubella live vaccine) between 3 months before and up to 3 months after conception. The data on these women are compared with similar ones from the USA (1096 women vaccinated with Cendehill, HPV77 or RA-27/3 vaccine within the same time-span in relation to pregnancy). The results indicate that the risk for the child from rubella vaccination of the mother before pregnancy and in the first trimester is minimal. Vaccination during early pregnancy is thus no compelling indication for the termination of pregnancy. However, known pregnancy continues to be a contraindication to rubella vaccination.

Antibodies, Viral↗
PubMed1983

[The significance of Peyer's plaques for intestinal immunity. Animal experimental inferences].

The removal of Peyer's patches alters the first line of defence against a known bacterium. Whereas in control animals all reactive cells could be found within the lamina propria of the gut, in rats without Peyer's patches only small amounts of IgA and IgM secreting cells could be detected there. In contrast IgA and IgM secreting cells could be found within mesenteric lymph nodes and spleen. The removal of the Peyer's patches diminishes the reaction of the lamina propria. Therefore other lymphatic structures like mesenteric lymph nodes and spleen get contact with antigenic material and generate E. coli specific immune globulin secreting cells. These cells were able to secrete IgA which was detected within the bile. This compensatory mechanism helps to restore the disturbed balance. The consequence of the systemic reaction against the E. coli must be discussed in view of cross reacting antibodies or the generation of inflammatory cells within the gut.

Animals↗
PubMed1983

[Rubella immunization with HPV77DE5 and RA 27/3 vaccines of 11 to 16-year-old girls: studies of antibody formation and antibody resistance after 4 and 8 years].

In the first prepubertal study 292 girls aged 11-15 years from 5 secondary schools were immunized with HPV77DE5 with the normal dose and 1/10 of it. The seronegative rate was 30.4%. HAI-antibody conversion occurred in 98.2 to 100%. The mean antibody titer in the two groups with 1:80 and 1:84 were 2 titer steps below the mean HAI-titer of the prevaccinal seropositive girls. The booster effect on the pre-existing titers was minimal. In the second prepubertal study with 625 girls aged 11-16 years from 3 gymnasiums 50.4% were seronegative. Of 312 seronegative girls, 56 had been immunized with HPV77DE5 s.c., 151 with RA 27/3 s.c. and 105 with RA 27/3 i.n. HAI-antibody conversion was observed in 98.2%, 100% and 100% respectively. The mean HAI-antibody titer following HPV77DE5 was +/- 2 titer steps, following RA 27/3 s.c. and RA 27/3 i.n. only 0.6 titer steps lower than the mean titer of the prevaccinal seropositive group. The individuals with a low prevaccinal antibody titer showed a significant but transient antibody booster response. Antibody titer controls 4 years post vaccination in 213 of the girls (160 prevaccinal seronegative, 53 prevaccinal seropositive) showed that all prevaccinal seronegatives had remained antibody-positive. The mean HAI-titer following HPV77DE5 was only slightly lower (1: 97) than 8-12 weeks post vaccination (1: 104) wereas the mean titers following RA 27/3 s.c. and i.n. showed a decline from 1: 158 to 1: 119 and from 1: 181 to 1: 111. The comparison of negative, low and higher HAI-antibody titers with neutralisation antibody titers in sera taken before, 8-12 weeks and 4 years after vaccination gave a perfect correlation between negative and positive results in both tests. Also 8 years post vaccination all vaccinees had remained seropositive. In comparison to the 4-year value, the geometric mean HAI antibody titer had dropped to somewhat lower levels of 1: 64, 1: 74 and 1: 64 respectively in the prevaccinal seronegative vaccinees so that no titer differences existed 8 years following vaccination in the different vaccine groups. Low positive HAI titers of 1: 16 were found in 3 of 23 (13%) in the HPV77DE5 group and in 2 of 76 (2.6%) in the RA 27/3 s.c. group but in none of 54 in the RA 27/3 i.n. group. The low positive HAI titer of 1: 16 could be confirmed in the HiG and ELISA IgG tests.(ABSTRACT TRUNCATED AT 400 WORDS)

Adolescent↗
PubMed1982

Serodiagnosis of Varicella-Zoster virus infection in pregnancy and standardization of the ELISA IgG and IgM antibody tests.

It is recognized that varicella virus infection in early pregnancy may cause severe congenital malformation and that varicella virus infection during the last 4 days of gestation until 48 h. after delivery can be dangerous for the child. Maternal Zoster has also been suggested as a cause of some congenital defect, but this association is poorly documented. Sensitive, specific and rapid indirect (ELISA) and direct (ELA) enzyme-linked-immunoassays for detecting Varicella and Herpes simplex virus, IgM-, IgA and IgG antibodies are employed for serodiagnosis of infection in the mother and the newborn and for determining the immunity status in high risk individuals who are exposed to V-Z infection. In the latter situation serological findings may serve as a guide for passive immunisation with Zoster-hyperimmunoglobulin (ZIG). The antibody concentration of the latter can now easily be standardized by the indirect ELISA-IgG-test. For determining the antibody concentration in the patient's sera in the indirect and direct ELISA with the method of Mona (Multiples of normal activity) a standardized test procedure using 2 optimal working dilutions has been established.

Antibodies, Viral↗
PubMed1979

Simple method to detect virus-specific IgM antibodies in patients' serum samples after immunosorption of immunoglobulins G and A.

By absorption with protein A and specific immunosorption using insolubilized adsorbentia (CPG), a method was developed for rapid elimination of IgG and IgA from patients' serum samples. This test technique was examined in the diagnosis of rubella infections, i.e., rubella-specific IgM antibodies. The procedure has proven to be as reliable as determinations carried out with IgM fractions separated on a sucroe density gradient.

Antibodies, Viral↗
PubMed1977

Cytomegalovirus as a frequent cause of Guillain-Barré syndrome.

In 10 patients with Guillain-Barré syndrome a preceeding cytomegalovirus infection could be demonstrated by virus-specific IgM antibodies that were present in high titers in 9 of the 10 patients in the first serum specimen. The IgM antibodies to cytomegalovirus were detected by a sensitive "double" indirect immunofluorescence technique. In most of our cases (8 of 10) the complement-fixing antibody titers had already reached high levels on admission into a hospital, and significant titer changes were not observed. Cytomegalovirus was isolated from the urine of five patients.

Adult↗
PubMed1976

[Guillain Barré- polyneuroradiculitis and Fisher-syndrome in cytomegalovirus infections (author's transl)].

In seven patients suffering from polyneuroradiculitis of the Guillain-Barré type and one case of Fisher syndrome, a cytomegalovirus infection was found. The elevation of the virus-specific IgM-antibodies was confirmed in all cases. The clinical course was severe and acute with respiratory disturbances, but complete remission occurred within 1-4 months. The complement fixing antibodies were highest during the first week of illness, so that further elevations could not be demonstrated, therefore making the IgM-antibody method of special importance. The role of cytomegalovirus infections in polyneuroradiculitis is also discussed.

Acute Disease↗