Of the sham operation.
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Biomedical subjects
Publications and source records attributed to G E Burch.
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Even though congestive heart failure is extremely common, the mechanisms responsible for the clinical manifestations remain a puzzle. The central and autonomic (sympathetic) nervous systems are responsible for a large part of the clinical manifestations. The role of the nervous system in CHF is discussed briefly. It is evident that there are many gaps in knowledge that remain concerning the role of the central, peripheral, and autonomic nervous systems in congestive heart failure. The peripheral vascular constriction, increase in venous tone and pressure, tachycardia, sweating, dermal pallor, and tension and anxiety in patients with CHF reflect generalized sympathetic nervous system activity and the influence of the central and autonomic nervous systems on the clinical syndrome of CHF.
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Echocardiographic manifestations of two patients with cardiac amyloidosis are presented. The findings consisted of increased thickness of the left ventricular posterior wall and interventricular septal wall, a normal to small left ventricular cavity, and pericardial effusion. The echocardiograph is useful in the evaluation of patients with cardiomyopathy and congestive heart failure.
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Precordial leads were first used by Waller, whose capillary electroscope was too insensitive to detect the electric forces emanating from the human heart unless the electrode was placed over the precordium as near to the heart as possible. When Einthoven developed the elegant, reliable and sensitive string galvanometer, he could record the electric forces of the heart from the hands and feet of the subject without even undressing him. When Einthoven's great galvanometer became available, only the three standard limb leads were used. Thomas Lewis and others experimented with precordial direct leads and made many important discoveries in electrocardiography and cardiology. Wolferth and Wood, in 1932, introduced the first precordial lead in clinical, diagnostic cardiology. The recordings were 'upside-down', i.e. positive deflections were down and negative ones up. They called this the 4th lead (lead IV). The precordial electrode was placed on the chest over the apex of the heart, regardless of where the apex was located. This immediately opened new avenues of study in infarction, ventricular hypertrophy, bundle branch block, and all other cardiac states. Then CL, CR, CF, CB and V leads were introduced. The points considered best for placing the 'exploring' or precordial electrode became an issue, and much confusion prevailed until Wilson and his associates developed the central or isopotential terminal and until the American Heart Association and the Heart Society of Britain and Ireland met in London and published the standards for recording precordial leads in 1938. There followed, for obvious reasons, a slow settling of the confusion until the V1 through V6 precordial leads became standard procedure all over the world, as exists today. Goldberger introduced the augmented unipolar limb leads (aVR, aVL and aVF) which have resulted in the standard 12-lead electrocardiogram of routine use today. No one would consider an electrocardiographic evaluation adequate in a cardiac study at present unless the 12-lead ECG were recorded.
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The small coronary arteries of two patients with alcoholic cardiomyopathy were studied by means of fine particle barium injection and soft x-ray technic. The spatial architecture of these small arteries which penetrated into the depth of the right and left ventricular myocardium were normal. Their lumina were somewhat dilated and their luminal surfaces were smooth. The "tree circulatory units" were described from this study and were found to be normal. The left ventricular myocardium was richly supplied with small arteries, whereas the myocardium of the right ventricle was not so richly supplied. The myocardium of the papillary muscles and the trabeculae carneae of the left ventricle also had a good supply of small arteries, as did the remote endocardial myocardial appendages. Numerous fine hair-like arteries extended to the epicardial myocardium of the right ventricle to form a brush-like appearance.
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