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Biomedical subjects

G E Andersen

Publications and source records attributed to G E Andersen.

At least 73 records · Page 4Linked to original sources
PubMed1979

Hyperlipoproteinemia in newborn infants. A study of 1025 families.

As part of a screening study for the detection of hyperlipoproteinemia in 10,000 newborns, cord serum lipids and lipoproteins were measured in detail in 1025 infants. Elevated cord serum VLDL-LDL-cholesterol could easily be identified by a rapid turbidimetric estimation of cord serum VLDL-LDL. Cord serum VLDL-LDL-cholesterol was found to be significantly higher than normal in premature, asphyxiated and beta-methasone-phenobarbital-ritodrine treated infants. Other obstetric complications, however, were not associated with hyperlipoproteinemia. Furthermore all 2050 parents had their serum cholesterol determined. 3 parents had familial hypercholesterolemia (FH). One child also had FH, though her cord serum total cholesterol and VLDL-LDL-cholesterol were normal. The 2 other children of the 3 FH parents, had normal lipids and lipoproteins both at birth and follow-up.

Cholesterol↗
PubMed1978

Stability of antibiotics and amino acids in two synthetic L-amino acid solutions commonly used for total parenteral nutrition in children.

The stability and interaction at 29 degrees C of ampicillin, carbenicillin, gentamicin, and polymyxin B were examined in a common electrolyte solution, invertose darrow, and in two synthetic l-amino acid solutions, one commercial (vamin with fructose; Vitrum) and the other a neonatal preparation modified for use in newborn infants. The concentration of amino acids was measured before and after the addition of these antibiotics. The concentration of antibiotics was measured over a 24-h period with a microbiological method. The concentration of ampicillin in invertose darrow fell 52%, and in vamin with fructose it fell 69%, whereas in the neonatal preparation the fall was only 22%. The concentration of carbenicillin in vamin with fructose fell 37%, and in the neonatal preparation it fell 31%. The combination of ampicillin or carbenicillin with gentamicin or polymyxin B did not influence the activity of the penicillins. The concentration of gentamicin and polymyxin B was unchanged in all solutions over a 24-h period. With the exception of cystine, the concentration of all amino acids remained constant after 24 h in the neonatal preparation with and without the different combinations of antibiotics. For cystine there was a fall of 20 to 30%.

Amino Acids↗
PubMed1977

Cord serum lipid and lipoprotein-cholesterol values in normal and betamethasone-treated newborns of varying gestational age.

Cord serum total cholesterol, very low density lipoprotein-, low density lipoprotein-, high density lipoprotein-cholesterol and triglyceride was determined in 30 AGA infants and 35 SGA infants born between the larger than or equal to 37th less than or equal to 42th week of gestation and in 26 AGA infants born between the larger than or equal to 33th less than 37th week of gestation. In SGA infants significantly higher VLDL-cholesterol and triglyceride values were found than in AGA infants. In AGA infants less than 37 weeks of gestation total cholesterol, LDL-, and HDL-cholesterol concentrations were higher than in AGA infants larger than or equal to 37 weeks of gestation. In 10 betamethasone-treated AGA infants less than 37 weeks of gestation HDL-cholesterol was higher than in 16 untreated AGA infants less than 37 weeks of gestation.

Betamethasone↗
PubMed1976

Neonatal screening for hyperlipoproteinemia. Methods for direct estimation of cord serum VLDL + LDL.

The early detection of hyperlipoproteinemia in newborn infants has so far been based upon estimation of cord blood total lipids (cholesterol and triglyceride) and lipoprotein-lipids (VLDL-, LDL- and HDL-cholesterol). To be able to make a direct estimation of cord serum beta-lipoproteins (VLDL + LDL) two quite different methods were modified, one immunological and the other turbidimetric. Good correlations were found to VLDL- + LDL-cholesterol isolated in the ultracentrifuge (r = 0.848 and 0.831, respectively). If neonatal screening for hyperlipoproteinemia is considered, we recommend the very easy and inexpensive turbidimetric method. Furthermore, using cord serum, two conventional precipitation methods with heparin-CaCl2 and heparin-MnCl2 were compared by ultracentrifugation and high correlations were found (r = 0.923 and 0.899, respectively). A clamping study showed that following early clamping of the cord, the concentration of cord serum lipids and lipoproteins did not change markedly within the first five minutes. Storing experiments showed that serum should be separated within the first 12 h to avoid unpredictable changes in the concentration of cord serum lipids and lipoproteins.

Animals↗
PubMed1976

Neonatal hypertriglyceridemia: a new index of antepartum-intrapartum fetal stress?

The 95th percentile value of cord serum triglyceride concentration in 82 consecutively live born infants was found to be 0.79 mmol/l. This level was arbitrarily used to define neonatal hypertriglyceridemia. A comparison between 78 normotriglyceridemic and 61 hypertriglyceridemic newborn infants showed a significant association between elevated cord serum triglyceride concentration and insufficiency of the placenta, fetal bradycardia, meconium-stained amniotic fluid and one-minute Apgar score less than or equal to 7. A significantly (p less than 0.001) greater number of infants with one or several of these four factors, indicating antepartum and/or intrapartum fetal stress were found to be hypertriglyceridemic at birth. This finding suggests that estimation of cord serum triglyceride which is easy and inexpensive might be of value for a more complete evaluation of the newborn infant, and can serve as a supplement to the Apgar Score system.

Cholesterol↗
PubMed1976

Neonatal diagnosis of familial type II hyperlipoproteinemia.

Cord serum prebeta-beta-lipoprotein concentration was measured in a radial immunodiffusion assay in 303 randomly selected, full-term infants whose parental phenotypes were unknown. Six infants had elevated concentrations, that is above a cut-off limit of 197 mg/100 ml (97.5th percentile). Three of these infants suffered from classic type II hyperlipoproteinemia, and this diagnosis was confirmed by family studies at follow-up. The three other infants and their parents were shown to be normolipemic at follow-up. The elevated cord serum prebeta-beta-lipoprotein in these three infants could be explained by highly elevated cord serum triglyceride and/or cholesterol. The 297 infants with normal cord serum prebeta-beta-lipoprotein and their parents were all shown to be normalipemic at follow-up. It is concluded that the measurement of prebeta-beta-lipoportein in cord serum allows the identification of children with familial type II hyperlipoproteinemia, if infants with transient neonatal hypertriglyceridemia and hypercholesterolemia are excluded.

Adult↗
PubMed1975

Neonatal diagnosis of Fredrickson type II hyperlipoproteinaemia.

Cord-serum beta-lipoprotein was measured by an immunological method in 303 children. The blood lipids were studied at 7-9 and 14-19 months after birth. The lipids of both parents were measured. Six children were found to have a greater than 2 SD elevation of beta-lipoprotein at birth. Three of these had hypertriglyceridaemia and 3 had type II hyperlipoproteinaemia. The rapid and quantitative measurement of beta-lipoprotein looks promising for screening of type II hyperlipoproteinaemia at birth.

Humans↗
PubMedDate not supplied

Plasma amino acid concentrations in newborn infants during parenteral nutrition.

Amino acid substance concentrations in plasma have been measured during total and partial parenteral nutrition with Vamin in 12 seriously ill newborn infants. When plasma amino acid concentrations were compared to the levels in reference infants, 11 of 21 were low, among the 11 were seven essential amino acids (Arg, Cys, Ile, Leu, Lys, Thr, Tyr), while concentrations above the reference median and range occurred for seven amino acids. For three (Asp, Glu, Phe) levels were exceptionally high. From these findings, from studies by others on amino acid levels during parenteral nutrition with Vamin, and from amino acid needs judged from venous-arterial differences in newborns, an amino acid preparation for parenteral administration to newborn infants is suggested.

Amino Acids↗