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Biomedical subjects

G E Andersen

Publications and source records attributed to G E Andersen.

At least 55 records · Page 3Linked to original sources
PubMed1982

Metabolic events in infants of diabetic mothers during first 24 hours after birth. II. Changes in plasma lipids.

Changes in plasma glycerol (FG), free fatty acids (FFA) and triglyceride (TG) were studied in 24 normo- and 8-hypoglycemic infants of diabetic mothers (IDM). In both groups a normal rise in plasma FG 2 hours after birth was found indicating unimpaired lipolysis. The rise in plasma FFA, however, was only about 50% of normal in normoglycemic IDM and about 25% of normal in hypoglycemic IDM. The rise in plasma TG was normal in normoglycemic and about 70% of normal in hypoglycemic IDM. The 2 hour rise in plasma FFA correlated with the 2 hour concentration of insulin and glucose, whereas the rise in plasma FG and TG did not. Maternal plasma FFA correlated with fetal FFA retention (umbilical vein minus artery (V-A) FFA concentrations). No correlations were found between maternal plasma FFA values and birth-weights nor between umbilical V-A FFA concentrations and birth-weights.

Adult↗
PubMed1982

Metabolic events in infants of diabetic mothers during first 24 hours after birth. III. Changes in plasma amino acids.

Plasma amino acid concentration (AAC) were studied in 31 diabetic mothers (10 of White class A, 10 of B-C and 11 of D-F) and their 32 infants during the first 24 hours after birth. Only minor differences between the 3 groups were found at birth and 2 hours, and none at 12 and 24 hours after birth. The individual AAC in umbilical vein plasma did not correlate with birthweight. All AAC except aspartic acid, asparagine, cystine and glutamic acid were higher in umbilical venous plasma than in maternal plasma. Umbilical venous-arterial differences of amino acids did not correlate with maternal or umbilical vein insulin concentrations except for threonine and valine. In general essential amino acids decreased after birth. In 8 infants with hypoglycemia and hyperinsulinism at 2 hours of age several plasma amino acids were lower than in the normoglycemic infants.

Adult↗
PubMed1982

Continuous intravenous infusion of ampicillin and gentamicin during parenteral nutrition in 88 newborn infants.

Ampicillin and gentamicin were dissolved once a day in an L-amino acid solution especially prepared for parenteral nutrition of newborn infants and infused continuously to 88 infants in whom septicaemia was suspected or had been proved. The mean dosages were 162 and 5.3 mg/kg per 24 hours respectively, and the 95% limits for the serum concentrations were 11-133 and 1.3-7.4 micrograms/ml. The treatment results were at least as good as with intermittent intramuscular or intravenous administration. This new mode of giving antibiotics is less painful to the babies and easier for the nurses.

Ampicillin↗
PubMed1982

Administration of gentamicin and ampicillin by continuous intravenous infusion to newborn infants during parenteral nutrition.

Gentamicin and ampicillin were dissolved in an L-amino acid solution especially prepared for newborn infants and infused intravenously over 24 h in 7 babies with serious neonatal surgical problems. Serum concentrations of the antibiotics were maintained rather constant and well above the minimal inhibitory concentration for most bacterial strains. One very sick newborn infant died with overwhelming Klebsiella pneumoniae septicemia. No signs of renal toxicity or ototoxicity were found. The serum amino acids remained within the normal range, except in 1 child with cytomegalovirus infection and liver insufficiency.

Amino Acids↗
PubMed1982

Serum lipoprotein and lymphocyte LDL receptor studies in parents and children with heterozygous familial hypercholesterolaemia.

In certain cases heterozygous familial hypercholesterolaemia (FH) cannot be confidently diagnosed from elevated serum lipid and lipoprotein values alone because of overlap with normal values. In the present study, therefore, lymphocyte high-affinity LDL receptor degradation of 125I-LDL was measured in 36 subjects from nine FH families. In eight families there was a good agreement between elevated serum lipid and lipoprotein values and reduced 125I-LDL degradation. In the ninth family, however, LDL receptor activity was normal in three subjects from three generations with elevated serum lipids and lipoproteins. The data suggest a disorder of LDL metabolism other than FH.

Adolescent↗
PubMed1981

Hyperlipemia among 1407 Danish children whose fathers have died from ischemic heart disease before age 45.

1407 children whose fathers had died from ischemic heart disease before age 45 were investigated. 15% had hypercholesterolemia and 8% hypertriglyceridemia at visit 1. At visit 2 and 3 this number of children with hyperlipemia fell to a minimum of 3% and 1.4%, resp. which is around 10 times higher than in a reference population. 1.8% of the children had familial hypercholesterolemia (FH) which is 10-15 times higher than in a reference population. These findings indicate that serum lipids should always be measured in children from such coronary heart risk families, and a decision made whether or not their permanent hyperlipemia should be treated.

Adolescent↗
PubMed1980

Lipids and lipoproteins in 350 Danish schoolchildren, ages 7 to 18 years.

Serum lipids and lipoprotein-lipids were measured in 350 Danish schoolchildren, ages 7 to 18 years. The children had been randomly selected and serve as an urban reference population. Only in boys did serum triglyceride and VLDL-cholesterol increase significantly with age, whereas the other lipoprotein-lipids remained almost constant during adolescence. LDL-cholesterol was found to be higher and HDL-cholesterol lower than in American children, suggesting that Danish children may be more prone to develop coronary heart disease in adult life.

Adolescent↗
PubMed1980

LDL receptor studies in children with heterozygous familial hypercholesterolemia (FH): measurement of sterol synthesis in blood lymphocytes.

Sterol synthesis was measured in lymphocytes from 48 members of 10 families with familial hypercholesterolemia (FH) under three sets of conditions. First the synthesis of LDL receptors and sterols were maximally stimulated by incubation of lymphocytes in lipoprotein-deficient serum. Secondly sterol synthesis was suppressed by the addition of LDL and thirdly sterol synthesis was maximally suppressed by the addition of 7-ketocholesterol. In five of the ten families LDL suppression of sterol synthesis in FH heterozygotes was only about half of the LDL suppression in normals. In four families, however, there was a considerable overlapping of LDL suppression in FH heterozygotes and normals. Finally in one family LDL suppression was strictly normal in FH heterozygotes who thus appear to have a different type of FH not involving an impaired LDL receptor function.

Adolescent↗
PubMed1980

The fatty acid composition of serum low density lipoprotein- and lymphocyte cholesterol esters in children with heterozygous familial hypercholesterolemia.

The content of free and esterified cholesterol in serum low density lipoprotein (LDL) was measured in 19 children with heterozygous familial hypercholesterolemia (FH) and in 10 normal siblings. In FH both free and esterified cholesterol were found to be elevated. Furthermore the fatty acid composition of serum LDL- and lymphocyte cholesterol esters was determined. However, no difference was found between FH heterozygotes and normals thus indicating that LDL-hypocatabolism typically found in FH does not correlate with an abnormal fatty acid composition of LDL-cholesterol esters nor with an impaired cholesterol esterification intracellularly in lymphocytes.

Adolescent↗
PubMed1980

Interrupted aortic arch in two siblings.

Two siblings with identical malformations consisting of complete interruption of the aortic arch, type B, ventricular septal defect, patent ductus arteriosus and anomalous origin of the right subclavian artery are described. Five other unrelated patients with interrupted aortic arch have been investigated in the years 1971--79. Of their 6 siblings, one had a coarctation of the aorta, while 5 were normal. Together with future reports this may help us to elucidate the genetics of this entity and may improve genetic counselling.

Aorta, Thoracic↗
PubMed1980

LDL receptor studies in term and pre-term infants: Measurement of sterol synthesis in cord blood lymphocytes.

Low density lipoprotein (LDL) receptor activity was measured in lymphocytes from pre-term and term infants in order to elucidate if the hypercholesterolemia found in pre-term infants might be secondary to a block in cholesterol transport across the cell membrane, analogous to that seen in familial hypercholesterolemia (FH). LDL receptor activity was found to be fully developed in pre-term infants and no different from that of term infants and of a normal adult control.

Biological Transport↗
PubMed1979

A clinical and neurophysiological investigation of a Danish kindred with heterozygous familial hypobetalipoproteinemia.

A three-generation transmission of under five percentile values for serum low density lipoprotein and low density lipoprotein cholesterol typical of heterozygous familial hypobetalipoproteinemia was demonstrated in a Danish family. Slight clinical signs of CNS abnormality were found in 4 of the 8 subjects with heterozygous familial hypobetalipoproteinemia, but did not resemble the neurological findings in abetalipoproteinemia nor in the previously described patients with familial hypobetalipoproteinemia. There were no signs of myelin dysfunction in the central nervous system as judged from the normal latency of visual and somatosensory evoked potentials.

Adolescent↗
PubMed1979

Dietary habits and serum lipids during first 4 years of life. A study of 95 Danish children.

Early infant feeding habits, current dietary intake and serum lipids were investigated in 31 infants, age 6--10 months and 64 children, age 3--4 years. In the infants there was a correlation between serum lipid levels and the amount of saturated fat and the P/S ratio of the diet. No such correlation was found in the 3--4 year old children. Neither was there any correlation between the type and duration of early infant feeding and subsequent serum lipid levels. In both the infants and the 3--4 year old children serum cholesterol concentration correlated with the serum cholesterol concentration in each of the parents.

Adult↗
PubMed1979

Screening for hyperlipoproteinemia in 10,000 Danish newborns. Follow-up studies in 522 children with elevated cord serum VLDL-LDL-cholesterol.

Among 10 440 newborns, 522 with upper 5 percentile values for very low-low density lipoprotein cholesterol in cord serum were selected for follow-up studies. Follow-up was possible in 446 of these 522 families (85%) and familial hypercholesterolemia (FH) was diagnosed in 11. In 273 of the 522 children, serum lipids were determined between the ages of 1 and 2 years and were now found to be normal, except in the 11 children with FH. Furthermore the serum lipids were compared in subgroups of these 273 children divided according to obstetric complications (i.e. low birth-weight, perinatal asphyxia and antepartum betamethasone treatment), which may cause a rise in serum lipids at birth. No differences were found between these subgroups at the age of 1--2 years.

Cholesterol↗