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Biomedical subjects

G Deutsch

Publications and source records attributed to G Deutsch.

98 records · Page 6Linked to original sources
PubMedDate not supplied

The functional status of the parathyroid in adult spasmophilia patients estimated by plasma parathormone assay.

In 25 cases of spasmophilia the parathyroid function was assessed by complete exploration of the P-Ca metabolism and radioimmunoassay (RIA) of parathormone (PTH). Concomitantly the bone mineralization status was assessed by induced hypercalciuria tests and administration of 30 mg vitamin D2. RIA of PTH revealed increased values in 50% of the cases. The values fall within the range of secondary hyperparathyroidism, but this percentage varies with the values of the parathyroid function obtained by P-Ca metabolism explorations. The increased PTH values do no correlate with the level of plasma total calcium, ionic calcium, and magnesemia. Nor do they correlate with the bone mineralization disorders or the duration of the disease and the age of the patients.

Adult↗
PubMedDate not supplied

The effect of intravenous potassium canrenoate in patients with severe heart failure and digitalis toxicity.

In 16 patients with critical condition due to severe heart failure associated with digitalis toxicity, the effects of potassium canrenoate (AldactoneR) administered intravenously were studied. Rhythm and conduction disturbances disappeared or improved in all instances. This effect was well correlated with an increase of serum potassium concentration. In 13 patients, after 1-2 days of Aldactone therapy, heart failure improved, which could be explained by a diuretic effect and by a possible inotropic action of aldactone. It is concluded that intravenous Aldactone is useful in patients with severe heart failure and digitalis toxicity in whom diuretics are often ineffective and even dangerous.

Adult↗
PubMedDate not supplied

Apolipoprotein (a) concentrations in type 1 (insulin-dependent) diabetes mellitus.

It has been suggested that insulin-dependent diabetes mellitus (IDDM) patients have higher values of lipoprotein (a)-Lp (a) that may account for their increased atherogenic risk, as related to non-diabetic subjects. We compared the plasma values of apolipoprotein (a)-(apo) (a) in type 1 diabetic patients (n = 26) hospitalized in our department and in non-diabetic subjects (n = 20) from Timişoara, Romania. IDDM patients had higher levels of apo (a) than controls [115(102-227) vs 58 (51-106) U/l; medians with 95% confidence intervals]; (p = 0.0083). Diabetes duration, the levels of hemoglobin A1 (Hb A1) and the values of body mass index (BMI) were not significantly related to apo(a) concentrations, while no correlations were found between apo (a) and plasma lipid values (total cholesterol (TC), low density lipoprotein cholesterol (LDLc), high density lipoprotein cholesterol (HDLc), triglyceride. A significant association was noticed between apo (a) and apo B both in IDDM patients (r = 0.43; 0.02 < p < 0.05), and in controls (r = 0.83; p < 0.001). We conclude that apo (a) levels are higher in IDDM patients than in non-diabetic subjects, but they are not related to the degree of glycemic control. Apo (a) and apo B are significantly correlated, both of them being well-known atherogenic risk factors.

Adult↗
PubMedDate not supplied

Apolipoprotein(a) concentrations in type 2 (non-insulin dependent) diabetic patients from Romania.

Several studies suggested that lipoprotein (a)-Lp(a) is an independent atherogenic risk factor. Since non-insulin-dependent diabetes mellitus (NIDDM) is characterized by an increased risk of coronary heart disease (CHD) as related to the general population, the main purpose of our study was to compare the plasma levels of apolipoprotein (a)-(apo) (a) in 30 NIDDM patients hospitalized in our department, and in 20 non-diabetic controls from Timişoara. Apo (a) values were similar in the two groups (medians, 95% confidence intervals 57 (50-107) in NIDDM versus 58 (51-106) U/l in controls; p = 0.9097). We found weak correlations between apo (a) and hemoglobin A1 (HbA1) (r = 0.42). A significant association was noticed between apo (a) and apo B, both in NIDDM (r = 0.71) and in control subjects (r = 0.81) p < < 0.001. The diabetic patients were screened for microalbuminaria with the MICRAL-test and we compared apo (a) levels in those having albumin excretion values above and under the cut-off point (20 mg/l). Apo (a) concentrations were similar in both samples. We found no association between apo (a) and plasma lipid values. NIDDM patients on fair glycemic control have similar apo (a) concentrations to non-diabetic subjects and they do not seem to be influenced by diabetes duration, HbA1, microalbuminuria and plasma lipid values Apo (a) and apo B are significantly correlated, both in diabetic and non-diabetic subjects.

Adult↗
PubMedDate not supplied

Apolipoproteins AI and B and plasma lipid values in well-treated diabetic patients from Romania.

This review is aiming to study the values of apolipoprotein AI and B and plasma lipid levels (total cholesterol, HDL cholesterol, LDL cholesterol and triglyceride) in well-treated diabetic patients, and their possible relationship with hemoglobin A1, body mass index and insulin levels. The study groups were 26 insulin-dependent diabetic (IDDM) patients, 30 non-insulin-dependent diabetic (NIDDM) subjects and 20 non diabetic subjects (controls). Apolipoprotein AI concentrations were similar in the three groups, but apolipoprotein B values and apo B/apo AI ratio were significantly higher in IDDM as related to NIDDM patients (p < 0.001) and to non-diabetic subjects (p < 0.001). We were not able to find significant differences concerning plasma lipid values between the three groups. We found a weak correlation between apo B and hemoglobin AI in IDDM (r = 0.45; 0.02 < p < 0.05), but not in NIDDM patients. Body mass index was not related to the values of apolipoproteins AI and B. We found a positive but weak correlation between insulin levels and triglyceride (r = 0.42), and an inverse one with HDL cholesterol (r = 0.57; 0.02 < p < 0.05) in non-diabetic subjects only, while in NIDDM patients these associations were even less significant. Plasma insulin values strongly correlate to body mass index in both NIDDM (r = 0.64; p < 0.001) and in control subjects (r = 0.73; 0.001 < p < 0.001).

Adult↗