Biomedical subjects
Publications and source records attributed to G Deppe.
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Pelvic pathology due to the parasite Echinococcus is infrequent in industrialized nations. It, however, may involve multiple organs and can mimic virtually any disease process. The parasitology, epidemiology, diagnosis, and treatment of hydatid disease is reviewed with particular emphasis on pelvic hydatid disease.
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Two patients with measurable recurrent endometrial adenocarcinoma achieved complete remission proven by second-look operation. Both patients were treated with a combination of melphalan, 5-fluorouracil and medroxyprogesterone acetate.
The pseudo-Meigs syndrome is clinically important because it resembles metastatic pelvic cancer. However, the prognosis is much more favorable when the syndrome is associated with a benign tumor. The authors point out that a woman with this condition can expect full recovery after surgery.
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Forty-six patients with recurrent disseminated ovarian carcinoma were treated with a combination of cis-dichlorodiammine platinum II (DDP) 50 mg/m2 and adriamycin 50 mg/m2 given intravenously every 3 weeks. All patients had failed prior chemotherapy. The combination of adriamycin and DDP produced objective responses in 14 of 46 patients. Severe side effects were frequent, but no patient died as a result of treatment. Disease in 4 of 7 complete responders is currently in remission up to 4 years.
Two patients with advanced adenocarcinoma of the fallopian tube were treated with cis-diamminedichloroplatinum, adriamycin, and progestins. Cyclophosphamide was added to the treatment of 1 patient. Both regimens achieved surgically proved complete remission. No severe drug-related toxicity occurred.
Three patients with advanced endometrial adenocarcinoma achieved prolonged clinical remission by treatment with hormonal and cytotoxic chemotherapy. Second-look surgery was employed to determine complete remission. Our preliminary experience with this procedure in patients with endometrial carcinoma is described.
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An additional case of familial occurrence of malignant melanoma is presented, involving mother and son. This is the fourth case of familial occurrence of malignant melanoma in the female genitalia and the first occurring in the vagina reported in the literature. We present a review of the literature concerning the hereditary property of malignant melanoma, including a list of all 92 families and 240 patients reported. The importance of a family history of malignant melanoma for the early diagnosis of this disease in relatives at risk is stressed.
The fetoplacental allograft and the malignant neoplasm represent the only 2 biologic conditions in which antigenic tissue is tolerated by a seemingly intact immune system. Recent investigations in the fields of tumor and pregnancy immunology have resulted in the recognition of a variety of immunologic mechanisms which are common to both systems. These common denominators are reviewed and a thesis suggesting a common mechanism in the nonrejection of pregnancy and malignancy, based on the presence of embryonic antigens in both systems, is presented.