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Biomedical subjects

G Deloche

Publications and source records attributed to G Deloche.

46 records · Page 3Linked to original sources
PubMed1977

Oligoclonal aspect in the CSF of multiple sclerosis patients: a statistical and physiopathological study.

Oligoclonal aspect (O.A.) is observed in 51 per cent of 468 MS patients investigated. Elevation of gammaglobulins and lymphocytic pleiocytosis increase significantly its frequency. O.A. is more frequent in presence of an inflammatory transsudate. Clinical aggravation and O.A seem significantly connected. In the first years of the MS, when the course is intermittent, the frequency of O.A. is significantly influenced by the proximity of the last bout. No such differences exist in patients with continuous course. In conclusion O.A. appears as intermittent expression of a local and general immunity reaction, in connection with the progression of the disease and as a very probable manifestation of persistant virus. We proposed 3 years ago in Göteborg a physiopathological hypothesis suggesting multiple sclerosis (MS) is a two-phase disease. In this first paper, we demonstrated the existence of two successive immunological reactions: The first one is an intermittent synthesis of IgG obviously linked to a lymphocytic pleiocytosis which is also intermittent. This firs CSF pattern appears in the same time of a bout and disappears quickly like the clinical symptoms. It may represent the manifestation of a brief and only infectious aggression. After a few years (more than 5 in average) a second mechanism progress slowly: The synthesis of IgG appears continuous, in remission as in aggravation, the lymphocyte count becomes normal and the level of albumin increases progressively. This second pattern suggests, contrary to the first, a continuous auto-immune processus with the intervention of the general (systemic) immunity. The purpose of this second paper is an attempt to elucidate the signification of oligoclonal aspect in relation to this schema.

Female↗
PubMed1976

Convolution computer processing of the brain electriacl image transmission.

A propagation model of electrical activities between the cerebral cortex and the scalp is presented in this paper. This work is based on a hypothesis of a distribution of cortical sources in a non-uniform dipolar sheet. The general field equations show that the electrical image of the cortex on the scalp is given by the convolution of the cortical potential and a transfer function. We then present several numerical evaluations with respect to the attenuation of the signal, the visual field of the electrodes and the approximation errors that have been introduced. Simulation experiments then enable us to test the behaviour of the model in comparison with complex electrical activities.

Brain↗
PubMedDate not supplied

Diversity of patterns of improvement in confrontation naming rehabilitation: some tentative hypotheses.

A previous group analysis of the effects of a computerized written naming rehabilitation program revealed global improvement with generalization of benefits to untrained items and to untreated oral naming (Deloche et al., 1992). The present multiple single-case analysis of the data indicates a variety of patterns of improvement and of generalization effects among individual patients. Patterns of relationships between written and oral naming behaviors help to explain the type of improvement that was observed.

Adult↗
PubMedDate not supplied

Post-traumatic haemorrhage in corpus callosum: a case study of disconnection syndrome.

This paper reports the case of a 16-year-old man who had sustained a traumatic head injury. Neuroradiological examinations showed haemorrhagic lesion in corpus callosum. The patient initially demonstrated several symptoms of disconnection syndrome; however, these clinical signs later resolved in subtle dysfunctions that could be evidenced only by statistical analyses of performances to specific tests. It is thus suggested that comparable cases may be undetected by standard examination procedures.

Adolescent↗
PubMedDate not supplied

[Programmed rehabilitation of a case of agraphia (author's transl)].

The authors describe a programmed method of rehabilitation suitable for patients with writing disorders resulting from cerebral lesions. The use of a visual display screen permits differential display and the immediate correction of errors. The application of the method is illustrated in the case of a patient with aphasic agraphia, and its general utility is briefly discussed in relation to the nature of various graphic disorders.

Adult↗