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Biomedical subjects

G D Dobben

Publications and source records attributed to G D Dobben.

43 records · Page 3Linked to original sources

Myelography wiht perfluoroctylbromide. Comparison with Pantopaque.

The efficacy and toxicity of perfluoroctylbromide in myelography were studied in dogs. Perfluoroctylbromide moves freely in intrathecal space and provides satisfactory radiopacity for diagnosis of subarachnoid structures. The outstanding feature of this substance is its low toxicity. The dog tolerates 0.5-1.0 ml/kg intrathecally without toxic manifestation. Histological studies and CSF analyses show that it is much less irriating than Pantopaque. Because of the long retention of the perfluorocarbon removal may be necessary. Perfluoroctylbromide shows promise as a diagnostic contrast medium, particularly in cases where the currently available contrast media are not suitable.

Animals↗

Vertebrobasilar insufficiency.

Permanent or transient reduction of the blood flow to the brain is often responsible for dizziness and occasionally sensorineural hearing loss. So far the diagnosis of this condition has been made by angiography, either carotid or vertebral arteriography, but there is a justified reluctance of subjecting unselected patients to this invasive procedure. It is the purpose of this paper to present a new approach to the diagnosis of cerebral vascular insufficiency based on a three-step protocol. The two initial steps are formed by noninvasive techniques and may be used for the selection of those cases requiring additional diagnostic procedures. 1) Cerebral hemodynamic evaluation provides a physiologic assessment of the direct carotid and indirect carotid and vertebral blood flow. It includes ocular plethysmography and ophthalmodynamometry obtained with the patient supine and erect, without and during carotid compression. 2) Computerized tomography allows an evaluation of the brain substance and of the changes produced by vascular insufficiency such as brain atrophy, infarcts and encephalomalacia. A new form of radiographic assessment based on a dynamic evaluation of regional blood flow will be introduced in this paper. 3) Carotid and vertebral arteriograms are performed only on these cases demonstrating a significant cerebral vascular insufficiency by the previous tests and in cases where corrective surgery is contemplated.

Aged↗

Hindbrain circulation and its evaluation by dynamic computed tomography.

Permanent or transient reduction of blood flow to the end-organs and to the hindbrain is the single major cause of vestibular disorders and a common cause of sensorineural hearing loss. New imaging modalities have become available which allow the recognition of focal areas of hindbrain ischemia in the prestroke stage. The correlation between focal ischemic pathology and clinical findings opens a new approach to the mapping of central pathology. In addition a detailed knowledge of the vascular anatomy of the hindbrain is indispensable for the development of new microvascular surgical techniques aimed at the restoration of sufficient blood supply.

Arteries↗

Multidirectional and computerized tomography of the vestibular aqueduct in Meniere's disease.

Multidirectional and computerized tomography have been used for the radiographic assessment of the vestibular aqueduct in Meniere's disease. The results of studies performed by us and/or other authors indicate that there is a statistically significant difference in the size of the vestibular aqueduct between the Meniere's and control groups (in Meniere's disease the vestibular aqueduct is often narrowed or obliterated); and that periaqueductal pneumatization is often decreased or absent in ears affected by Meniere's disease. Recent histological studies performed on temporal bones of patients with Meniere's disease have confirmed these radiographic observations.

Humans↗

CT in the evaluation of the orbit and the bony interorbital distance.

The distance between the orbits and their individual dimensions are important in the diagnosis of craniofacial anomalies. Most observers rely on standard radiographs for measuring the bony interorbital distance. Tomography of the skull base and orbital computed tomography (CT) can also be used. This article describes the normal range of the bony interorbital distance and other useful orbital linear and angular measurements as determined from a series of CT scans of the orbits in 400 adults who had CT for other purposes. The normal interorbital distance measured at the posterior border of the frontal processes of the maxilla on nonrotated scans, in the plane of the optic nerve, ranges from 2.29 to 3.21 cm (average, 2.67 cm) in men and 2.29 to 3.20 cm (average, 2.56 cm) in women. The widest interorbital distance lies behind the posterior poles of the globes. This ranges from 3.16 to 4.10 cm (average, 3.37 cm) in men and 2.93 to 3.67 cm (average, 3.20 cm) in women.

Adolescent↗

CT densitometry of the cochlear capsule in otosclerosis.

Cochlear otosclerosis can be recognized in most cases by high-definition axial and coronal CT images. However, routine technique does not allow a quantitative measurement of the changes. Reported here is a study of cochlear CT densitometry. The densitometric profile of the cochlear capsule was obtained in 10 ears with normal hearing and 50 ears in 27 patients with known clinical otosclerosis and progressive mixed-type hearing loss. Patients with hearing loss had decreased absorption of as much as 60% in comparison to the normal range. In 42 ears with abnormal densitometric profiles, the changes were visibly apparent on the CT images, whereas in eight others, the densitometric profile alone demonstrated decreased absorption.

Adult↗