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Biomedical subjects

G Coscas

Publications and source records attributed to G Coscas.

At least 181 records · Page 10Linked to original sources
PubMed1986

[Erdheim-Chester disease. The multiviceral form presenting as exophthalmos].

Erdheim-Chester disease is a rare visceral xantho-granulomatosis, the 17th case of which is reported here. The initial symptom, bilateral exophthalmos, was uncommon. The picture was completed by a retroperitoneal xanthogranuloma and by bilateral and symmetrical osteosclerosis of the long bones. The lack of X-bodies at electron microscopy differentiated the disease from Hand-Schüller-Christian disease. The patient's condition improved with chemotherapy (vinblastine and doxorubicin) combined with corticosteroid therapy. After a 5-month remission period, he died of an intercurrent infection. No autopsy was performed.

Diagnosis, Differential↗
PubMed1986

Best's vitelliform macular dystrophy.

We examined and evaluated the ophthalmological findings of 47 patients with Best's Vitelliform Macular Dystrophy (BVMD) and 5 cases suffering from related conditions to this macular disorder. Our sample re-confirm that BVMD is a progressive disease which may have several appearances in the course of its evolution. The heredity of this disorder is autosomal dominant with reduced penetrance and variable expressivity. Some contradictions exist regarding the nature of the primary defect in this entity. Electrooculographic and angiographic investigations lend support to the belief that the basic pathological changes are located in the retinal pigment epithelium. However, recent histopathological findings and flicker electroretinographic results indicate the possibility that the photoreceptor cells are equally involved, even before the pigment epithelium. In view of the existing disagreements about the pathogenesis of this disorder, certain considerations were advanced which suggest that the basic pathologic process in this entity produces a disorganisation in the structural and functional interdependance of both the photoreceptor cells and pigment epithelium.

Adolescent↗
PubMed1985

Cases reported at the FAN club meeting, Bonn, November 1984. Case 1: A case of preretinal neovascularization after retinal artery occlusion.

A 63 year-old man presented with an occlusion of the inferior temporal artery in his right eye, followed ten days later by an obstruction of the central retinal artery. Internal carotid stenosis was diagnosed and the patient underwent carotid endarterectomy. The retinal arterial circulation was restored except in the previously occluded inferotemporal artery. Nine months after the occlusion, preretinal new vessels began to grow at the border of the ischaemic area. Possible mechanisms governing the proliferation of new vessels after retinal arterial occlusion are discussed.

Angiography↗
PubMed1985

Influence of pregnancy on the evolution of background retinopathy. Preliminary results of a prospective fluorescein angiography study.

Previous reports have suggested that pregnancy does not influence the development of diabetic retinopathy. Since 1979 a prospective study using fluorescein angiography has been in progress. Preliminary results include 22 diabetic women with or without moderate background retinopathy studied until delivery. They were maintained under good metabolic control (mean HbA1: 7.68%). Five clinical and fluorescein angiography examinations were performed at prefixed intervals (before the 15th week, at the 28th and 35th weeks of pregnancy, and 6 and 15 months after delivery). The analysis of fluorescein angiography which did not induce any side effect showed that the mean number of microaneurysms increased from 42.7 before pregnancy to 56.7 at the 28th week and to 79.7 at the 35th week. Six months later the number was 62.7, and 15 months later 60.3, still higher than at the initial examination. This study suggests that pregnancy has an unfavourable influence on the background retinopathy in diabetic patients even when a good metabolic control is achieved and retinopathy is minimal.

Adult↗
PubMed1985

Vitreous fluorophotometry studies in aphakia.

Vitreous fluorophotometry was performed on 63 patients undergoing cataract extraction. Pre- and postoperative studies demonstrated that this procedure always induces alterations in the blood-aqueous barrier. A correlation was found between the degree of this alteration and the frequency of cystoid macular edema.

Aged↗