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Biomedical subjects

G Corsini

Publications and source records attributed to G Corsini.

At least 55 records · Page 3Linked to original sources
PubMed1981

[R wave variations during the bicycle exercise test].

R-wave changes have been measured in 90 normal subjects during exercise testing on the bicycle. We have found a 22,2% R-wave mean decrease in all the subjects independently from their age. This results, in our opinion, may be due to the heart volume decrease during dynamic exercise in normal subjects. In according to the Brody effect, heart volume reduction decrease radially orientated cardiac vectors and therefore QRS amplitude is reduced.

Adult↗
PubMed1981

[Effect of isometric force (handgrip) on R wave amplitude].

We have measured R-wave amplitude during isometric stress-handgrip test in 30 normal subjects, without finding any significative variation. We believe, in according to our angiographic and echocardiographic experience, that such a behaviour is due to the absence of heart volume modification during handgrip test.

Adult↗
PubMed1980

[Effect of some anticoagulant drugs on granulocyte capillary migration].

We have investigated the effect of four anticoagulant drugs (Calbiochem Heparin, Liquemin Roche, EDTA and Na citrate) on polymorphonuclear granulocyte capillary migration to evaluate a possible modification induced by these drugs on migration function. We can state that any modification is induced by these drugs on granulocyte capillary migration in vitro.

Anticoagulants↗
PubMed1980

[Rheographic evaluation of peripheral blood flow during isometric exercise].

A rheographic evaluation of peripheral blood flow during isometric contraction (handgrip) has been done in 25 attendants of the Air Force Medical Service (mean age :20 years). The velocity of sphygmic wave, the sphygmic amplitude and, the peak time, heart rate and blood pressure have been measured at rest and during handgrip. The velocity of sphygmic wave does not change in all the subjects; the sphygmic amplitude is decreased of 10% (p less than .001), the peak time is decreased of 9% (p less than .001). Because sphygmic amplitude and peak time are directly proportional to flow volume, and their reduction significantly express a decrease of flow volume. The authors believe that the blood flow reduction is induced by the excitation of sympathetic peripheral alpha-receptors, not more balanced from sympathetic cholinergic vasodilator fibers. The actual result is an increase of the peripheral vascular resistances.

Adult↗
PubMed1980

Effect of single oral dose of phenobarbitone on lymphocyte blastogenic response in man.

A single oral dose of phenobarbitone 1.5 mg kg-1 was given to 18 normal subjects to evaluate the effects on lymphocyte function. Serum barbiturate concentrations and lymphocyte blastogenic response to three mitogens (PHA, Con A, PWM) were tested before and at 2, 12 and 36 h after drug administration. A serum barbiturate plateau of about 2 microgram ml-1 was maintained from 2 to 36 h. Lymphocyte blastogenesis was reduced with barbiturate compared with controls. However, the reduction was significant only at 36 h (P < 0.01).

Adult↗
PubMed1979

[Changes induced with varying solutions of normal plasma on granulocyte capillary tube migration].

In the present work we have evaluated the effect of decreasing concentrations of normal plasma in TC 199 on leukocyte capillary migration. From the 1st to the 4th hour of migration, normal plasma at 100%-80%-60%-40% concentration, significantly inhibits leukocyte migration. The inhibitory effect is lost, only by a few plasmas, at 60% and 40% concentration, during the following migration hours. Normal plasma at 20% and 10% concentration doesn't show any inhibitory effect on leukocyte capillary migration. Therefore, for clinical studies on pathological plasmas we recommend the use o plasma at 20% or 10% concentration to avoid aspecific inhibition.

Cell Movement↗
PubMed1979

[Standardization of the method of granulocyte capillary tube migration].

In the present work a method is described to standardize each step of leukocyte capillary tube migration assay. The conclusions of our study are: natrium heparin can be used as anticoagulant; the use of calibrated microcapillaries is recommended; migration chambers must lay on a horizontal surface; results can be evaluated by a ocular for radial immunodiffusion from the 16th to 20th hour of migration.

Cell Movement↗