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Biomedical subjects

G Constantinides

Publications and source records attributed to G Constantinides.

At least 19 recordsLinked to original sources
PubMed1992

[Gold salt deposits in the conjunctiva in rheumatoid arthritis after gold therapy. A systematic study of 15 biopsies].

Ocular abnormalities have long been recognized as a potential adverse effect of gold therapy in patients with rheumatoid arthritis. Clinical symptoms and ocular tissue lesions possibly related to use of gold therapy were routinely evaluated in eleven patients. There were few clinical manifestations: only one patient had typical accumulation of gold in the anterior crystalloid. In contrast, routine ultrastructural and microprobe studies of conjunctival biopsy specimens disclosed accumulation of gold salts in every case. Gold was visible as aurosomes in the conjunctival macrophages. Aurosomes were seen in patients treated for as little as one month, occurred even with low doses (0.3 g), and were still visible after several years. Duration of accumulation can be roughly estimated on the basis of the morphologic appearance of aurosomes which are lamellar after a few weeks of gold therapy and rod-shaped beyond one month.

Adult↗
PubMed1992

High hyperopia with papillomacular fold.

We report a case of evolutive high hyperopia in a child aged 10 years. It is associated with organic amblyopia due to a large papillomacular retinal fold. Ultrasonography and CT scan helped to establish the diagnosis. This is probably a hereditary disease affecting the development of the posterior sclera.

Child↗
PubMed1991

Retinochoroidal coloboma and subretinal neovascularization.

Subretinal neovascularization associated with retinochoroidal coloboma is rare. To the authors' knowledge, only three cases have been reported. We report a new case of isolated subretinal neovascularization and coloboma in a 26-year-old woman without other causes of choroidal neovascularization. Only the disruption of the normal retinal anatomy could explain the development of this subretinal neovascularization.

Adult↗
PubMed1990

[Treatment of macular holes by vitrectomy and gas].

Five cases of retinal detachment with macular hole show the effectiveness of the treatment: Vitrectomy + exchange Fluid-gas. Red krypton laser applied around macular hole is not necessary. Treatment vitrectomy-exchange Fluid gas must be performed rather than Aspiration-gas in a first attempt.

Aged↗
PubMed1989

[Xerophthalmia caused by self-induced deficiency disease].

Xerophthalmia is no longer seen in Europe since the 19th century. We report the case of a female patient, aged 33, of french nationality, who presented a clinical picture of major vitamin A deficiency, self-induced and with ocular complications. An untreated long standing depressive condition appeared to be the major etiologic factor. Perforation of a desmetocele necessitated penetrating keratoplasty. Histologic corneal and conjunctival aspects are reported. Oral prescription of vitamin A resulted in considerable clinical improvement. Only 3 similar cases have been previously reported. Clinical manifestations of xerophthalmia are described along with preventive and curative therapy.

Adult↗
PubMed1989

[The use of expansive gas in retinal detachment complicated by vitreoretinal proliferation].

We used quantities of perfluoropropane as a substitute of vitreous in some cases of retinal detachment with vitreoretinal proliferation. It seems to be a good method compared with the injection of silicon oil for in 23 cases treated recently, the evolution of the vitreoretinal proliferation seems to have stopped better than with silicon oil. Postoperative intraocular pressure surveyance is highly advisable.

Adult↗
PubMed1989

[Role of polarized light in the formation of images in the fundus of the eye. Preliminary results of a study of 130 cases].

On a basis of a series of a 130 color photographies registered under polarized light, we have studied the respective part of mass reflexions and of diffusions on the formation of fundus images. The results show that the retina is the main centre of mass reflexions which disappear in polarized light. The pigment (hemoglobin, melanin, etc...) become the main factors of the formation of fundus images. We conclude on the risks of errors which can be done by extrapolating the informations given by photography to assess the action of photocoagulation.

Humans↗
PubMed1988

[Malignant intraocular non-Hodgkin's lymphoma].

The authors presented two personal cases of ocular involvement by non hodgkin's malignant lymphomas. The first one concerned a 55 year-old man; initial symptoms were oedematous optic neuropathy associated to vitritis, uveitis and chorio-retinal infiltrates. The ocular symptoms did not respond to cortico-steroid therapy and lymphoma was diagnosed eight months later by histologic examination of a cerebral tumor discovered by C.T. scan. Systemic examination was normal. In spite of a cerebral radiotherapy associated to chemotherapy, uveitis and vitritis occurred in the other eye and vitreous biopsy of the most affected eye showed no cell abnormalities. The patient died two years after the onset of ocular symptoms. The second case concerned a 67 year-old woman who presented an association of absolute glaucoma secondary to uveitis with retinal detachment and neurological symptoms due to a cerebral tumor detected by C.T. Scan. Histological examination of the enucleated eye confirmed the diagnosis of centroblastic lymphoma: choroid, retina and optic nerve were involved. A data review consisted of a study of 93 cases with the same pathological conditions and permitted a discussion about the main clinical features of this affection and the different histological aspects. The following classification of the different forms of ocular lymphomas was proposed: isolated associated to cerebral and/or to systemic localizations. The management of a treatment by radiotherapy was discussed, based on the previous reports, and a prognosis of oculo-cerebral lymphomas was given.

Aged↗