Biomedical subjects
Publications and source records attributed to G Colella.
The authors report on ultrastructural study of large nerve trunks, preterminal section of axons and sympatic contacts with chromaffin cells in adrenal gland of "Anas boscas". Only in rare cases, islets of chromaffin cells occur in the deep parts of parenchyma and, in their center, a fray of nerve fibres can be described.
252 turkey eggs were put in an incubator at 39 degrees C and relative humidity 75%. From the 8th day of incubation up to the 28th, the authors opened 12 eggs a day, 6 at 8 a.m. and 6 at 8 p.m. The embryos were fixed by 10% buffered formaline for three days, dehydrated by alcohol 96% for seven days, eviscerated, coloured by alizarin S red and by alcian blue 8GX, then made diaphanans by means of KOH solutions. Then the authors have described the appearance times of the ossification nuclei in turkey, showing that in turkey the embryonal ossification occurs in a characteristic chronological order, different from that described in other birds, even if they belong to related species.
For this investigation 35 domestic ducks of variable age (2 months - 2 years) and both the genders were utilized. After sacrificing them some were injected with celluloid or neoprene latex and from the other, samples of hhepatic tissue were excised for the preparation of tissue sections. Therefore the distribution of arterial and venous blood vessels and the portal veins as well as the distribution of the bile ducts were described. The problem of "visceralization" of the liver was studied and found that analagous to that which has been observed in other birds, in the duck it is not as complete as in the mammals, both on account of the presence of some parietal rami, and because of the relations that some visceral rami take directly with the epatic veins or with the caudal vena cava.
The structural and histological characteristics of the limiting layer between the cortex and medulla of the bursa of Fabricius in the duck are described in relation to different functional moments of the organ. On E.M. study the limiting layer, in duck having 30 days of age, is constituted of reticular-epithelial cells palisades in shape with many cytoplasmics extension. Lymphatic migration occur in interstitial spaces.
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The microcirculation of thymic lobule has been studied. The vascular feature is markedly different compared with mammalian thymic circulation. Only one artery trunk, the intralobular thymic artery branching off from intralobular artery has been evidentiated. Interlobular arter penetrates the lobule and originates a bed of narrow thin-walled capilary network, thinner in the pheriphery.
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In bovine bronchia a peribronochial nervous plexus, two thin one around polmonary arteries and veins and an inner plexus disposed in the mucous structures have been evidentiated. Numerous big nervous ganglia in connection with peribronchial plexus, particularly in the wider bronchia have been observed: in the mucous and submucous membrane of wider bronchia, sensitive nervous terminations are located.
The lymphatic component in the pharynx of Buffalo presents some peculiar characteristics of species above all as regards the palatine tonsil. This is characterized by the presence of numerous lobes, by the fast pigmentation of the mucosa in the sinus and sometimes by the crypts and by the wealth of glandular adenomeres. The lingual tonsil, the tonsil of the soft palate, the pharyngeal tonsil and the tubal tonsil are represented by lymphatic elements arranged in the lamina propria of the mucosa and only sometimes they are organized as follicles.
The innervation of the mucous membranes in the paranasal cavities of "ovis aries" appears homogeneous as regards the various nasal sinuses. It is represented by numerous nervous bundles which are in the deep and middle parts of the mucous membranes, and have sensory terminals and fibres assigned to the vessels and glandular adenomeres. In the subepithelial stratum can be noted a superficial plexus from which come off the fibres assigned to the epithelial elements of the mucous membranes.
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The unique availability of an explanted liver-islet allograft, removed for primary nonfunction of the liver, led us to evaluate distribution and phenotype of exocrine and endocrine components of the pancreatic graft. Immunocytochemistry was used to map patterns of gene products for islet hormones, proprotein processing enzymes, panneuroendocrine markers, and pancreatic exocrine markers. When compared with age-matched control pancreases, insulin-, glucagon-, somatostatin-, and pancreatic polypeptide-producing cells were similarly represented and distributed within the grafted islet. We also demonstrate that the intrahepatic transplanted islets retained the enzyme machinery able to process the hormone precursors into bioactive fragments. In the clinical setting, this resulted in an immediate functioning of the graft and insulin-independence of the patient one month after transplantation. The purity in islets, as assessed by immunocytochemistry with antibodies to tissue constituents of endocrine and exocrine lineages, was around 40%. Despite the massive intraportal presence of pancreatic acinar tissue, no signs or symptoms attributable to ectopic hypersecretion of exocrine enzymes occurred. In fact, when tested with antibodies to such enzymes, low levels of immunoreactivity were observed in the grafted acinar cells.