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Biomedical subjects

G Cennamo

Publications and source records attributed to G Cennamo.

At least 37 records · Page 2Linked to original sources
PubMed1997

Endothelial cells evaluation two years after photorefractive keratectomy.

To evaluate long-term corneal endothelium damages after myopic photorefractive keratectomy (PRK) a morphometric analysis of corneal endothelial cells was performed in 41 patients before and at least 24 months after photorefractive keratectomy. These patients underwent a treatment ranging from -2.5 to -14 dpt with a mean of 8.9 +/- 2.8 dpt at the corneal apex, with an estimated corneal thinning ranging from 23 to 123 microns with a mean of 78 +/- 24.4 microns. Our results showed that the density of endothelial cells ranged from 2,334 to 3,554/mm2 with a mean of 2,819 +/- 351/mm2 before surgery, and from 2,051 to 3,461/mm2 with a mean of 2,774 +/- 330/mm2 after surgery without any significant changes (p = 0.16). The polymorphic index ranged from 58 to 84 with a mean of 77 +/- 5.7 before PRK and from 57 to 89 with mean of 77.7 +/- 7.2 after treatment without any significant changes (p = 0.61). In conclusion, we can state that there is no long-term corneal endothelial damage after PRK even in highly myopic eyes.

Adolescent↗
PubMed1996

Refractive outcome and corneal topographic studies after photorefractive keratectomy with different-sized ablation zones.

BACKGROUND: Discrepancies may still occur between planned and actual refractive correction in eyes undergoing photorefractive keratectomy (PRK). The authors have evaluated the use of an enlarged ablation zone. METHOD: A computerized corneal analysis system has been used to compare the changes of the anterior surface of the cornea and the refractive changes before and 1, 6, and 12 months after PRK in 113 patients (119 eyes) treated with an excimer laser. The patients were divided into two groups: those treated with a mask with a 5-mm window (59 eyes), and those with a new mask with different window openings according to the degree of refraction at the corneal apex, starting from 5 mm in diameter for treatments less than 6.5 diopters (D) and from 7 mm in diameter for higher treatments (60 eyes). In the first group, treatment ranged from -2.5 to -16 D (mean +/- standard deviation. -8.5 +/- 3.24 D); in the second group, it ranged from -1 to -14 D (-7.8 +/- 3.06 D). Treatments were evaluated with a chi-square test. RESULTS: In the first group of eyes, 46% were within +/-1 D at 1 month, 37% at 6 months, and 39% at 12 months. In the second group of eyes, 73% were within +/-1 D at 1 month, 60% at 6 months, and 58% at 12 months. The comparison between these data and corneal topographic changes shows that both are more stable and predictable with the new mask compared with the 5-mm mask (P = 0.002, 0.02, 0.04, at 1, 6, and 12 months, respectively). CONCLUSIONS: The use of larger ablation zones improves the predictability and stability of refractive changes.

Adult↗
PubMed1996

Macula study with standardized echography.

At an early clinical stage, patients with cystoid macular oedema show no significant changes in their vision. This phase is described as angiographic cystoid macular oedema. Echographic macular studies have in the past years shown that the macular thickness is increased in the early stages of cystoid macular oedema. In these patients there was no evidence of cystoid macular oedema with the visual acuity test, B-scan echography and fluorescein angiography. In this paper an echographic macular study by standardized A-scan echography was performed in 537 patients before extracapsular cataract extraction and intraocular lens implantation in posterior chamber (ciliary sulcus). The results showed that this method is very sensitive in detecting patients with high risk of cystoid macular oedema.

Adult↗
PubMed1995

Effects on the corneal endothelium six months following photorefractive keratectomy.

Photorefractive keratectomy (PRK) with a 193-nm excimer laser has been shown not to destroy endothelial cells in vivo. However, this laser could damage endothelial cell metabolism, and result in damage over a longer term. In this paper, a comparison between the number and shape of corneal endothelial cells has been performed in 25 patients before and 6 months after PRK. These patients underwent treatment with myopic correction ranging from 2.5 to 17 dpt and with an estimated corneal thinning ranging from 25 to 170 microns. No significant changes in the number (p = 0.167) and shape (p = 0.075) of endothelial cells have been found. These results show that there are no long-term damages after PRK even in severely myopic eyes.

Adult↗
PubMed1994

First experience with a new echographic contrast agent.

The intravenous injection of an ultrasound contrast agent can enhance signals from blood flow. Broad toxicological and pharmaceutical studies in animals confirmed the safety and efficacy of an ultrasound contrast agent made of microparticles of galactose with stabilised microbubbles in watery suspension (SH U 508 A). In this paper 10 patients with different malignant orbital and ocular tumours have been evaluated with an echo colour Doppler machine before and after the injection of SH U 508 A. An enhancement of the Doppler signals in the lesions in different degrees has been detected. This echographic contrast agent seems to be very important not only in the evaluation of vascular lesions, but also in evaluating the effectiveness of radiotherapy in malignant tumours and could spread the echographic indications in several other ophthalmic fields.

Adult↗
PubMed1994

Phototherapeutic keratectomy in the treatment of Avellino dystrophy.

Avellino corneal dystrophy has rarely been reported in literature. It consists of a combination of granular and lattice dystrophy. Patients may complain of glare and decreased night vision with or without decreased visual acuity, depending on the degree of corneal involvement. Current treatment for this dystrophy includes bandage contact lenses for the erosions or corneal transplant in the case of decreased visual acuity. We describe the first patient with Avellino corneal dystrophy to have been treated with phototherapeutic keratectomy.

Aged↗
PubMed1994

An unusual orbital lesion: hepatoma metastatic to the orbit.

The authors describe a case of histologically proven orbital metastasis from a hepatic carcinoma in an 85-year-old patient with rapid onset of proptosis and visual loss. The clinical diagnosis of orbital metastatic lesion was established by standardized echography and CT scan. To the best of our knowledge, this is only the third histologically proven case of hepatoma metastatic to the orbit.

Aged↗
PubMed1993

Echographic and ophthalmodynamometric study in the empty sella syndrome.

A group of patients with empty sella syndrome (ESS) and visual field defect with or without visual loss has been examined with standardized echography and ophthalmodynamometric examination. The optic nerve thickness has been evaluated with standardized echography; the pressure of the central retina artery has been evaluated with ophthalmodynamometric examination with or without compression on the external carotid. Our results point out two different pathogeneses in the ESS: vascular defects or irregular endocranial hypertension.

Empty Sella Syndrome↗
PubMed1993

Optic nerve involvement in acute lymphoblastic leukemia.

Leukemic infiltration of the optic nerve is rare. We describe the diagnostic assessment and the outcome in two adult patients suffering from acute lymphoblastic leukemia with T phenotype. In both cases the leukemic involvement of the eye was observed as an isolated extramedullary relapse followed after several months by hematological relapse. CT and MRI scans were negative, while an A-scan echography of the eye clarified the diagnosis. Early radiotherapy caused recovery of visual acuity in one case. A-scan echography is the most sensitive investigation for the early recognition of ocular localization in acute leukemias.

Adult↗
PubMed1992

Standardized A-scan echography and the normal optic nerve. Experience with the new Mini A equipment.

The potential of making differential diagnosis in optic nerve disease with standardized A-Scan echography has been well established. With this technique it is possible to differentiate 'solid' and 'fluid' thickening. A few years ago a new standardized A-scan equipment was built: The Mini A. With this equipment, it is possible to distinguish spikes coming from the pia, the arachnoid, and the dura around the optic nerve, and to measure the thickness of these structures with a precision of 0.03 mm. We found dura distance 4.0-5.3 mm, arachnoid 3.2-4.0 mm, an pial diameter 2.8-3.4 mm. In this paper the authors discuss their preliminary findings in a normal population.

Adolescent↗
PubMed1992

Comparison between echographic and histological findings in choroidal malignant melanomas.

Echography is crucial in making a diagnosis of malignant melanoma when ocular media are opaque. Even with clear ocular media, standardized echography is important to confirm or to rule out a malignant melanoma in the eye. In this study the reflectivity in 27 cases of malignant melanomas has been evaluated and compared to cell type, pigmentation and number and size of blood vessels. No significant correlations have been found.

Choroid Neoplasms↗
PubMed1991

Choroidal thickness in primary glaucoma.

A and B scan echography does not allow to measure separately the thickness of the three ocular layers, retina, choroid and sclera. This, however, is possible by radiofrequency signals. 48 eyes of normal subjects and 21 eyes of patient suffering from chronic glaucoma with ocular hypertension from 30 to 45 mm Hg were examined. The thickness of the retina and sclera was equal in the two groups, whereas the thickness of the choroid in the glaucomatous eyes showed an increase of 20% as compared with normal eyes.

Adult↗
PubMed1990

Choroidal osteoma (osseous choristoma): an atypical case.

A case of choroidal osteoma presenting in a 22-year-old girl is reported. The tumour, unilateral and in a juxtapapillary site, appeared markedly elevated on the retinal plane, not flat or slightly elevated as in previous reports. Visual acuity was not affected, and there was a complete absence of subjective symptoms. Echography, fluorangiography, computerised tomography, and visual field tests were performed. Echography is the best method for identifying and differentiating this lesion from a malignant tumour.

Adult↗
PubMed1989

Morning glory syndrome associated with marked persistent hyperplastic primary vitreous and lens colobomas.

A case of morning glory syndrome with striking persistence of primary vitreous is presented. The hypothesis that the syndrome is an expression of abnormal closure of the embryonic fissure is substantiated by the coexistence of lens colobomas. Furthermore, the marked primary vitreous hyperplasia shows the way in which persistence of primary vitreous influences the clinical expression with respect to optic pit and colobomas of the optic nerve.

Adolescent↗
PubMed1989

[Evaluation of cellular immunity in a selected sample of aged subjects].

The immune system in the aging man is known to show age-related defects; the study of the subpopulations in human blood has yielded conflicting results. This mostly seems to be due to the heterogeneity of the subjects admitted to immunogerontological studies. We investigated a group of aged persons fulfilling the admission criteria described in the "SENIEUR" protocol and strictness criteria dietetics. We found a decrease in the number of T cells, while the number of B cells and, above all, the report of the T4/T8 remained constant. There individuals should be considered as optimally healthy and immunologically uncompromised.

Adult↗
PubMed1987

Echographic measurement of the optic nerve in patients with intracranial hypertension.

Measurement of the optic nerve diameter by echographic technique has been performed in 40 patients with intracranial hypertension syndromes of various origin. In all the cases examined the diameter was always increased. Postoperative checks revealed a decrease of the nerve thickness until it reached the normal values. The changes in the optic nerve diameter reflect the variations of the intracranial pressure and they appear earlier than any changes in the fundus oculi. This simple and non-invasive echographic technique is very useful in following patients with an intracranial hypertension syndrome.

Brain Neoplasms↗
PubMed1986

Morning glory syndrome with chronic simple glaucoma.

A 42-year-old woman had morning glory syndrome of the fundus of the right eye. The finding was related to chronic simple glaucoma and without pulsation of the staphyloma. The clinical symptoms and echographic pattern during the endocular hypertensive phase with normal intraocular pressure was studied after appropriate medication. This associated disease is attributed to the presence of a congenital malformation of the anterior chamber angle.

Adult↗