Biomedical subjects

G Cazzato

Publications and source records attributed to G Cazzato.

96 records · Page 6Linked to original sources

PubMedDate not supplied

[Amaurosis fugax].

A follow up study has been performed in thirteen patients suffering from (amaurosis fugax) (A.F.). From the case material analysis and from the review of the current literature it has been possible to infer that the current pathogenetic hypotheses (cerebral and/or retinal microembolism) of the amaurosis fugax and of the transient ischemic cerebral attacks without ocular symptoms are similar, at least in the most of the cases. In all the cases of amaurosis fugax examined, the clinical symptomatology, the frequency of the episodes and the time required for its complete recovery have been described. Some (risk factors) of cerebrovascular disease, such as hypertension, diabetes mellitus and high plasma levels of cholesterol and triglycerides, have been statistically analyzed using Student's t test and chi-square. As regards other possible risk factors (ischemic heart disease, peripheral vascular diseases, chronic obstructive pulmonary disease) only a statistical frequency analysis has been performed. The results of the anti-platelet therapy in modifying the frequency of the A.F. episodes have been discussed. It has been lastly considered the results of the follow-up study in regard to the prognosis of the A.F.

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PubMedDate not supplied

[Hematocrit value and hemoglobin concentration as possible risk factors in non-embolic acute cerebral infarcts].

The hematocrit and the concentration of hemoglobin have been studied in 197 patients (125 men and 72 women) suffering from acute cerebral infarction not due to embolism. The results have been analysed statistically and compared to those of a control group formed by 123 neurologic patients (68 men and 55 women) chosen at random, belonging to the same age range and with no cerebrovascular disease. The hematocrit was significantly higher in the patients who had a cerebral stroke of a non-embolic origin, both males and females, than in the control group, although it was within normal limits. As far as the concentration of hemoglobin is concerned, there is a significant statistical difference between patients with and without cerebral infarction, but only for the female patients.

Adult↗

PubMedDate not supplied

[The blood level of uric acid as a risk factor in transient cerebral ischemic attacks and in non-embolic acute cerebral infarct].

The serum uric acid level has been determined in 300 patients, both males and females. 125 of these suffered from transient cerebral ischaemic attacks and 175 from atherothrombotic brain infarction. The values obtained were compared with those determined, with the same technique, in a control group of patients with neurologic diseases, chosen at random, and with no clinical finding or historical data of cerebrovascular and/or cardiac disease. No significant statistical difference has been observed between the mean serum uric acid level in the patients with transient ischaemic attacks, or brain infarction, and the control group. All the patients examined were divided according to sex and age. As far as sex was concerned, males suffering from cerebral transient or completed focal ischaemia, had on average a lower serum uric acid level compared to the control group. The opposite happened with females. As far as age was concerned, significantly high serum uric acid levels, compared to the control group, were observed in women with either transient ischaemic attacks or brain infarction, but only in those whose age range was between 50 and 60. In conclusion, from this study, hyperuricemia does not appear to be a high risk factor in ischaemic cerebrovascular diseases.

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PubMedDate not supplied

[Hematocrit and hemoglobin in the pathogenesis of transient cerebral ischemic attacks].

The hematocrit and the concentration of hemoglobin have been studied in 77 patients (42 men and 35 women) affected by transient cerebral ischaemic attacks involving carotid or vertebral-basilar arterial system. The results have been analysed statistically and compared to those of a control group, formed by 123 neurologic patients (68 men and 55 women) chosen at random, belonging to the same age range, and with no acute or chronic cerebrovascular disease. The hematocrit and the concentration of hemoglobin, although within normal limits, were significantly higher than in the control group only in the male patients with transient cerebral ischaemic attacks.

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PubMedDate not supplied

[Prevention and therapy of delirium tremens with tiapride].

One hundred chronic alcoholics, who were hospitalized in our ward for neurological disorders directly or indirectly due to a prolonged and continual consumption of alcohol, have been treated with tiapride in doses varying from 600 up to 1200 mg/die. The drug was administered either per os or by injection. 50 of these patients were given, at the same time, graded doses of alcohol per os. The purpose of this study was to analyse the preventive and therapeutical effects of the drug both on ten "target symptoms" examined separately, and on the onset and duration of the alcohol abstinence syndrome. We have noticed that decreasing doses of alcohol, in the first days of hospitalization, were unable to reduce significantly the onset of fits of delirium tremens. Tiapride showed a reasonably good therapeutical activity on some features of the "target symptoms": it shortened the average duration of the symptoms, while it did not prove better than benzodiazepines in inhibiting the onset of the same. The drug was unable to prevent the onset of the abstinence syndrome, and, even if it had a favourable control over the symptoms, it was unable to shorten their duration. The mortality rate was similar to that of other reviews where benzodiazepines, or major drugs acting on the nervous system, were employed. The sedative action of tiapride, even at higher doses, was insignificant, and its hypnotic effect almost absent. No extrapyramidal disorders have been observed, at least up to 1000 mg/die.

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PubMedDate not supplied

[The use of a single anterior oblique field in the treatment of T1aN0 vocal cord neoplasms. Results and comparison with other technics].

From 1985 through 1993, 113 patients affected with T1N0 glottic cancer were treated with irradiation alone at the Radiotherapy Department of Umberto I Hospital in Mestre, Italy. An anterior oblique beam of 12 MV X-rays (LINAC) or gamma-rays of a Cobalt unit were used. Dose distribution was always studied on CT scans and with a Theraplan V05-B, Theratronics. Patients age ranged 40-92 years (mean: 64.7 years) and they were mostly males. The dose was always 60 Gy/30 fractions referred to the 90% isodose. The dose to the target volume ranged 90-105%, with a mean of 99%. The follow-up ranged 26 to 98 months; the median and the mean are 38 and 40 months, respectively. Six patients had local relapses and were all operated on: cordectomy was performed in 3 of them and laryngectomy in the other 3. Radiation therapy yielded 94.7% disease control; the lesion was ultimately controlled in 100% of patients after surgical salvage. Fifteen patients died, all of them of non-neoplastic disease. The authors compared this technique with those most frequently used, i.e., wedged opposed lateral fields and wedged anterior oblique beams, and observed that it allows minimal volumes to be irradiated with maximal doses and yields results. Wedged beams are not necessary with this technique. The authors consider irradiation the treatment of choice for early glottic cancer and believe that surgery, with the conservative approach if feasible, should be limited to relapses.

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