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Biomedical subjects

G Cazzato

Publications and source records attributed to G Cazzato.

At least 91 records · Page 5Linked to original sources
PubMedDate not supplied

[The hematocrit and atherothrombotic cerebral infarcts].

The authors compare the hematocrit values of 131 patients suffering from an acute cerebral atherothrombotic infarct, confirmed by CT scan, with those of 165 controls of the same age and sex. Both the analysis of the average by the Student's t test and the comparison between the distribution of frequencies by the chi square test, point out that hematocrit is significantly higher (p less than 0.001) in infarcts than in controls. Dividing patients according to CT scan (negative, lacunar infarct, cortical and/or subcortical infarct), no significant difference in hematocrit levels among the three groups is noticed. The authors confirm the positive association between hematocrit and atherothrombotic cerebral infarct and discuss the possible implications in the prevention and the therapy of cerebral ischemic stroke.

Blood Viscosity↗
PubMedDate not supplied

[Ticlopidine and amaurosis fugax: results of treatment in a case with very frequent and typical attacks].

In a 59 years old patient suffering from a non stenotic atheroma of the internal right carotid artery, 12 attacks of "amaurosis fugax" (a.m.) affecting the right eye occurred over a period of 36 days. Ticlopidine at doses of 500 mg and subsequently of 250 mg per day was administered and the attacks of "amaurosis fugax" briskly stopped. In the 8 month period following the occurrence of the last episode of monocular blindness, the patient continued the therapy with ticlopidine and no visual disturbances were more reported. The most likely pathogenetic hypotheses of "amaurosis fugax" in the present case are discussed as well as the possibility that the relation between the attacks of a.m. and the beginning of the treatment with ticlopidine might be fortuitous.

Carotid Artery Diseases↗
PubMedDate not supplied

[Smoking and Parkinson's disease].

Reports that tobacco smokers are at a lower risk of incurring Parkinson's disease (PD) than are non smokers and that a high percentage of Parkinsonians stop smoking before the onset of the disease, were reinvestigated by study of 110 hospital patients with PD and 110 other patients. In contrast to controls, fewer patients ever smoked cigarettes (39.1% versus 7.3%); moreover, many Parkinsonians (82%) stopped smoking before the onset of the disease. The high percentage of patients with PD who stopped smoking might by explained by premorbid behavioural modifications related to the biochemical cerebral changes already present in the preclinical stage of the disease.

Adult↗
PubMedDate not supplied

[Smoking and acute cerebrovascular disorders of the ischemic type].

In order to define the relationships between cigarette smoking and occurrence of cerebrovascular disease, a retrospective study was undertaken regarding smoking habits of 187 patients (129 men and 58 women) with cerebral infarct of non-embolic origin and 85 patients (40 men and 45 women) with TIA (transient ischemic attacks). Each patient was matched with a control subject, of the same sex and age group, who showed no signs or symptoms of cerebrovascular disease. Results show a statistically significant association between smoking habits and cerebral infarcts only in male subjects who smoked more than 20 cigarettes a day.

Aged↗
PubMedDate not supplied

[Use of ticlopidine in patients with acute non-embolic cerebral infarcts].

Different dosages, varying from 250 to 500 mg/die, of ticlopidine per os have been employed in 46 patients (32 men and 14 women), average age 66, who had been admitted for acute non-embolic cerebral infarction. In the two clinical examinations, effected on average 5.4 and 18.3 days after the admission, significant alterations in 9 among the considered items have been noticed, i.e.: central deficit of the VIIth cranial nerve, motor function and gait impairment, Babinski's sign, loss of sensibility, dysarthria, visual field defect, cerebellar signs, motor and/or receptive dysphasia. A global improvement of these clinical signs has been noticed on average in 48.2% of the patients, while an exacerbation has occurred in 2.1% of the cases. None of the patients who have been considered in this study has decreased or has shown relapses of ischemic cerebral attacks during the observation. The treatment with ticlopidine has been discontinued in 3 cases (6.5%) for the occurrence of temporary adverse side-effects.

Acute Disease↗
PubMedDate not supplied

[Prevention and therapy of delirium tremens with tiapride and chlordesmethyldiazepam].

Forty alcohol abusers (with a history of long-time alcohol addiction and mean daily use over 360 grams of alcohol) were treated with tiapride or chlordesmethyldiazepam when stopped their overdrinking. The aim of such pharmacological treatment was both a valuation of effectiveness towards ten target-symptoms and the attempt to avoid the development of a withdrawal syndrome-or, at least, to shorten its course. Chlordesmethyldiazepam resulted to be on the whole more effective than tiapride in dominating all most dramatic symptoms of Delirium Tremens and in avoiding--in a significantly higher number of patients--the onset of a DT syndrome in all its typical features. Moreover, CDDz appeared as a manageable drug and free from important side-effects, and could control symptoms without need of further therapies.

Adult↗
PubMedDate not supplied

[Familial nature of acute cerebral vasculopathies of the ischemic type].

The frequency of cerebrovascular accidents and of risk factors including hypertension and diabetes was examined retrospectively in parents and siblings of 328 patients suffering from transient ischaemic attacks or non-embolic cerebral infarction and in a control group. The frequency of cerebrovascular accidents was significantly higher in the family of the patient compared to the family of the control. The relatives of the patient and the control had essentially the same frequency of diabetes, whereas hypertension was significantly more common in the family of the patient. When the relatives with one or both the risk factors were excluded and those with cerebrovascular accidents alone were compared, a greater frequency, though insignificant, was noted in the family of the patient. Hypertension and diabetes were more common in the relatives of the patient than in the control but this difference was not statistically significant. The significant excess of cerebrovascular accidents in the family of the patients suffering from transient ischaemic attacks and non embolic cerebral infarction cannot exclusively be attributed to the greater frequency of diabetes and hypertension.

Acute Disease↗
PubMedDate not supplied

[Nyctohemeral incidence of acute cerebral vasculopathies].

The time of onset of the neurological symptomatology was studied retrospectively in 258 patients, 107 (41%) autopsized, affected by non embolic cerebral infarction (172 cases), cerebral haemorrhage (52 cases) and subarachnoid haemorrhage (24 cases). In the patients suffering from cerebral infarction or haemorrhage the symptomatology began more frequently in the morning hours (from 6 to 12 a.m.) while it was comparatively rare in the night (from 00 to 06 am.). and evening hours (from 6 to 12 p.m.). This difference was significant (p less than 0.01) at the chi-squared test. The patients with subarachnoid haemorrhage showed a more homogeneous distribution with a higher but not significant frequency in the morning hours. The nyctohemeral distribution does not significantly differ in the patients affected by cerebral infarction, cerebral haemorrhage and subarachnoid haemorrhage. The time of onset of the neurological symptomatology shows no significant variation in the patients with cerebral and subarachnoid haemorrhage after dividing them in normotensives and hypertensives, while in the hypertensive patients with cerebral infarction a significant higher frequency of strokes was observed in the night hours (from 00 to 06 a.m.).

Acute Disease↗
PubMedDate not supplied

[Dyslipidemias and ischemic cerebral vasculopathies].

The serum cholesterol and triglycerid levels have been studied in 50 patients affected by transient ischaemic attacks (TIA) and in 89 patients suffering from cerebral infarction of non embolic origin. In 25 patients with TIA and in 59 patients with cerebral infarction, the HDL-cholesterol level and the HDL-cholesterol and total cholesterol ratio have also been determined. Every patient was matched with a control of the same age and sex for statistical proposal. The mean total cholesterol concentration was significantly higher in the male patients affected by TIA and cerebral infarction. Dividing the patients according to age, the mean total cholesterol level remained significantly higher only in the male patients with TIA under the age of 60. The mean triglycerid concentration was significantly higher as compared with the controls in the male patients with TIA under the age of 50 and in the female patients with TIA aged from 60 to 70. The HDL-cholesterol level, though lower than in controls, showed no significant variation both in patients with TIA and with cerebral infarction, excepting the male patients affected by cerebral infarction over the age of 70. The HDL-cholesterol and total cholesterol ratio was insignificantly lower than in controls both in TIA and in infarct patients. These results seem to emphasize the role of total serum cholesterol level in the pathogenesis of ischaemic cerebrovascular diseases particularly in the male patients under the age of 60. Less striking appears to be the role of serum triglycerid level. Finally we can't show a significant HDL-cholesterol reduction in our patients as compared with controls.

Age Factors↗