Search PubMed⌕ Search

Biomedical subjects

G Capella

Publications and source records attributed to G Capella.

At least 37 records · Page 2Linked to original sources
PubMed1992

[Rebound hyperglycemia and peroperative normalization of insulinemia. Complete excision of insulinoma?].

Clinical usefulness of the hyperglycemic rebound and the normalization of plasma insulin level as intraoperative markers of complete removal of insulinoma was assessed. Surgical removal was curative (no clinical or biological recurrence) in six patients harboring a single adenoma (mean follow-up = 32.2 months). In these patients plasma glucose increased an average of 32 mg/dl 30 minutes after resection, 68 mg/dl after 60 minutes, and 91 mg/dl after 90 minutes. Sensitivity of hyperglycemic rebound (defined as a plasma glucose increment of at least 30 mg/dl after tumor removal) as a marker of complete resection of the insulinoma was 40% at 30 min and 83% at 60 minutes after resection. Preresectional values of plasma immunoreactive insulin were elevated in 3 out of 4 patients with adenoma. All postresectional values were within normal ranges. Two patients operated on because of malignant insulinoma, underwent partial tumor resection; hyperglycemic rebound was also present, and high preresectional insulin values became normal 30 minutes after partial tumor removal. We conclude that information provided by intraoperative monitoring of both plasma glucose and insulin cannot be used as the only markers of complete resection of all insulinomas. Only long term clinical and biological follow-up can guarantee the complete resection of an insulinoma.

Blood Glucose↗
PubMed1991

Frequency and spectrum of mutations at codons 12 and 13 of the c-K-ras gene in human tumors.

The frequency of point mutations at codons 12 and 13 of the c-K-ras gene has been determined in a panel of more than 400 human tumors. Mutant c-K-ras genes were detected in about 75% of adenocarcinomas of the pancreas (n = 84); 40% of adenomas (n = 72) and carcinomas (n = 244) of the colon end rectum; 30% of carcinomas of the bile duct (n = 19); 25% of carcinomas of the lung (n = 92), and in lower frequency in other carcinomas, including liver, stomach, and kidney. No mutations were found in carcinomas of the breast, prostate, esophagus, and gall bladder, among others. Comparative analysis of the spectrum of mutations show that while G to A transitions were the most frequent mutations in pancreatic and colo-rectal tumors, G to T transversions were more prevalent in lung carcinomas. The aspartic acid mutation at codon 13 (GGC----GAC) was relatively frequent in colo-rectal tumors but rare in pancreatic and lung carcinomas. The differences in the mutation spectrum of the c-K-ras gene in cancers of the gastrointestinal and respiratory tracts are suggestive of differential exposure to genotoxic agents.

Base Sequence↗
PubMed1991

[Gastric villous adenoma. 2 new cases].

Villous adenomas are extremely rare in the stomach. This type of lesion is characterized by its high capacity of malignant degeneration, as well as by its association with other tumors of the gastrointestinal tract. In this regard, we present two cases of villous adenoma of the stomach observed in our hospital, as well as a review of the characteristics of these tumors and of the treatment required.

Adenocarcinoma↗
PubMed1990

Mutational activation of the c-K-ras gene in human pancreatic carcinoma.

We have reported the presence of c-K-ras oncogenes activated by single point mutations at codon 12 in a vast majority of human pancreatic carcinomas. Formalin-fixed, paraffin-embedded specimens from surgical resections, autopsies and biopsies were used as well as snap frozen surgical specimens. The high oncogene incidence has been confirmed in other studies and indicate that somatic mutational activation of the c-K-ras gene is an important event in the development, maintenance or progression of cancer of the exocrine pancreas. While the role that these point mutations play in any or all of these processes remains to be determined, their presence is useful clinically for the diagnosis of pancreatic carcinoma at the molecular genetic level. The detection of mutated c-K-ras oncogenes in fine needle aspirates of pancreatic masses, that by cytomorphology may be suspicious but not diagnostic of malignant disease, increases the sensitivity of the diagnosis for this cancer. The identification of codon 12 mutations in the c-K-ras gene in pancreatic adenocarcinomas has been possible by advances in recombinant DNA techniques, especially by the development of in vitro gene amplification by the polymerase chain reaction (PCR). The possibility of analysing formalin-fixed, paraffin-embedded tissue for the presence of genetic alterations as small as single point mutations by PCR in concert with other mutation detection techniques, should facilitate the molecular genetic analysis of pancreatic carcinoma. Retrospective studies using stored specimens are now feasible with the technology described and should yield important information on the molecular epidemiology and aetiology of this and other diseases.

Adenocarcinoma↗
PubMed1989

[Laryngeal paraganglioma].

A case is reported of laryngeal paraganglioma observed among 49,959 patients. A comparison is made of the characteristics of paragangliomas in general to those of laryngeal paraganglioma, which are more common in males; the case presented is that of a woman. Microscopic dissection failed to reveal the paraganglia in the trajectories of the superior and inferior laryngeal nerves, but they were found in histological sections of these nerves and their images were equal to those of the tumor studied. The trajectory of these nerves was investigated in preparations of the Embrioteca de Bellaterra (Prof. Doménech Mateu) and the clumps of paraganglioma cells from which these tumors proceed have been found; we emphasize the concept of neural crest pathology to which they pertain.

Adult↗
PubMed1988

Von Recklinghausen neurofibromatosis with carcinoid tumor and submucous leiomyomas of the duodenum.

We report on a 63-year-old man with von Recklinghausen neurofibromatosis who developed a carcinoid tumor in the periampullary region and multiple small-sized leiomyomas in the duodenal wall. A high prevalence of gastrointestinal carcinoids has previously been recognized in patients with von Recklinghausen neurofibromatosis, the commonest site of origin being the duodenum or the periampullary region. The association of both conditions seems to be more than casual. Abnormalities in the development of the complex of von Campenhout or high circulating levels of nerve growth factor have been the mechanisms postulated to account for this association.

Carcinoma↗
PubMed1986

Chronic myocarditis leading to a right ventricular cardiomyopathy. Case report.

A case of dilated cardiomyopathy arose after a spontaneous abortion at the second month of pregnancy is reported. Whereas clinical, hemodynamic and gross features pointed to a diagnosis of right ventricular cardiomyopathy, histologic findings of inflammatory infiltration, myocyte degeneration and interstitial fibrosis of the atrial and ventricular walls allowed to a correct diagnosis of chronic myocarditis.

Abortion, Spontaneous↗
PubMed1986

[Right cardiac echinococcosis with coronary compression. Description of a clinical case].

An outstanding case of cardiac echinococcosis is described. Clinical symptomatology was characterized by typical nitroglycerin-responsive crisis of angina pectoris associated to an electrocardiographic pattern of negative T wave on anterolateral and inferior leads. The diagnosis was suspected on the basis of thoracic computerized tomography and coronary arteriography. The anatomical localization was mainly pericardial but the right ventricle was involved too. Left anterior descending artery was dislocated and squeezed.

Adult↗
PubMed1983

[The association between liver cirrhosis and bacterial endocarditis. Description of a typical case].

A typical case of an association of cirrhosis of the liver and bacterial endocarditis involving only the aortic valve is described. The essential role of echocardiography in diagnosis and the ability of the technique to supply useful information for correct therapy is emphasised. Finally, evidence that, in spite of all negative blood cultures, Escherichia Coli via the urinary ways may be considered the aetiological agent is presented.

Aortic Valve↗
PubMed1983

[Complete sub-His AV block caused by carotid sinus massage. Possible direct vagal effect on the His-Purkinje system].

A 64 year old male patient, with frequent syncopes, underwent an electro-physiologic study. A complete left bundle branch block and a first degree His-Purkinje system atrioventricular block (AH = 100 msec, HV = 60 msec) were present in basal condition. Left carotid sinus massage caused extreme sinus bradycardia (with PP intervals as long as 3000 msec), without AH and HV interval changes. Right carotid sinus massage caused a His-Purkinje atrioventricular block. Ventricular asystole of 4800 msec occurred while the sinus cycle varied between 1440 and 590 msec. Since His-Purkinje atrioventricular block is induced by the right carotid sinus massage with PP intervals even shorter than the basal cycles and since the block was not reproduced at PP intervals longer than 1440 msecs, a direct vagal effect on the His-Purkinje system may be suggested, rather than a bradycardia dependent phase 4 block.

Bradycardia↗
PubMed1980

The in vitro effect of a calf thymus extract on the peripheral blood lymphocytes of patients with warts.

T and B lymphocyte populations were evaluated in forty-one patients with multiple recurring warts. Active rosettes (T-Ea) and total T lymphocytes (T-Et) were significantly decreased. The in vitro effect of a calf thymus extract (TP-I) on peripheral blood lymphocytes was evaluated in thirty-three patients. A statistically significant increase in E-rosette forming cells was observed in twenty-three patients (69%). Serum blocking factors were not found in the patients with a positive response to TP-I, which suggests the possibility of a thymic hormone deficiency. In the case of non-responders to TP-I, on the other hand, an anti-lymphocyte antibody capable of directly blocking the hormone receptors on the undifferentiated lymphocytes may be postulated.

Adolescent↗
PubMed1979

The in vitro effect of a calf thymus extract on the peripheral blood lymphocytes of sixty-six melanoma patients.

The in vitro effect of a calf thymus extract (TP-1) on peripheral blood lymphocytes was evaluated in sixty-six melanoma patients. Twenty out of forty-five stage I and seventeen out of twenty-one stage IIb patients presented depressed T lymphocyte values. A statistically significant increase in E-rosette-forming cells (E-RFC) was observed in seventeen (85%) stage I and twelve (70.5%) stage II patients. In thirteen (65%) stage I and eight (47%) stage II patients E-RFC reached normal values. Our results indicate that the fall of T lymphocytes in the peripheral blood of melanoma patients is often related to an increase in TP-1 sensitive cells which suggests the possibility of a thymic hormone deficiency in these patients.

Adult↗