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Biomedical subjects

G Bucht

Publications and source records attributed to G Bucht.

61 records · Page 4Linked to original sources
PubMed1979

Monoamines and monoamine metabolites in brains from demented schizophrenics.

The brains from 12 schizophrenic patients were investigated post-mortem for their content of noradrenaline (NA), dopamine (DA), 5-hydroxytryptamine (5-HT), homovanillic acid (HVA), and 5-hydroxyindolacetic acid (5-HIAA). Six of the schizophrenics had been lobotomized 25--30 years prior to death. A control group matched for age was collected in the autopsy room. The concentrations of NA, DA, and HVA in different parts of the brain from the schizophrenic group did not differ from those of the controls. 5-HT was determined in 11 nuclei or areas of the brain. The schizophrenic group had lower mean values compared with the controls, and in the hypothalamus, medulla oblongata, and hippocampus the difference was at a significant level. 5-HIAA was determined in six areas of the brain but only in a few cases. There was a trend towards lower means of 5-HIAA in the schizophrenics. Cause of death, medication, food intake, age, time between death and autopsy, time the corpses have lain in room temperature, and dissection technique are discussed in relation to these findings. These variables have to be kept under careful control before changes can be claimed as having pathogenetic importance for schizophrenia or for the progressing dementia in this disease.

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PubMedDate not supplied

Albumin and immunoglobulin in plasma and cerebrospinal fluid, and blood-cerebrospinal fluid barrier function in patients with dementia of Alzheimer type and multi-infarct dementia.

Plasma and cerebrospinal fluid (CSF) from 20 patients with Alzheimer's dementia or senile dementia of Alzheimer type (AD/SDAT), 23 with multi-infarct dementia (MID) and 16 controls were assayed for their content of immunoglobulins (Ig) and albumin (Alb). The concentrations of IgG and Alb were used to analyze the blood-CSF barrier function in the respective group. MID patients had significantly (P less than 0.001) elevated plasma IgG levels compared to controls and AD/SDAT patients. CSF concentration of Alb was significantly higher in MID (P less than 0.01) and AD/SDAT (P less than 0.05) patients compared to the controls. Concentration of CSF IgG was significantly (P less than 0.05) lower in AD/SDAT patients compared to the MID patients; no significant differences were found when CSF concentrations of IgG of demented patients were compared to controls. These findings may indicate a blood-CSF barrier dysfunction especially in cases with MID with significantly (P less than 0.001) elevated values of transudation. Also these findings indicate a non-specific and/or specific binding of IgG in CNS tissue and/or vessel walls in both forms of dementia on the basis of low IgG ratios compared to proportionally higher Alb ratios. There were no signs of local synthesis of IgG in CNS in either group of demented patients.

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PubMedDate not supplied

Epidemiology of delirium.

Delirium is one of the most frequent symptoms of disease in the elderly. A large variation of incidence and prevalence data is reported probably due to different patient populations and inconsistent diagnostic criteria. In medical and surgical elderly inpatients recent studies report a prevalence rate of approximately 15% and in postoperative patients the incidence and prevalence rates vary greatly, 7-52%, depending on patient population and clinical setting. In nursing homes the prevalence is even higher and delirium is often combined with dementia. Data supports the statement that delirium is most often found in hospitalized somatically ill elderly patients. As a consequence of the rising number of elderly in hospitals we have to expect an increase in the prevalence and incidence of delirium.

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PubMedDate not supplied

Drug consumption during the last decade among persons born in 1902 in Umeå, Sweden. A longitudinal population study.

A population study of drug consumption among people born in 1902 was performed in Umeå, Sweden. The cohort was followed between 79 and 88 years of age. The number of persons in the study varied between 124 and 72. Mean consumption increased from 2.5 to 5.2 drugs per man and from 3.3 to 5.3 per woman. The main correlate of this increase was shown to be the aging individuals' greater morbidity. Cardiovascular preparations, analgesics, psychoactive substances and drugs used to alleviate gastrointestinal symptoms were the most common. At the age of 88 years, 45 to 55% of the individuals used drugs belonging to each one of these drug groups. Furthermore, during the 9 years of study there was a substantial increase in use of these drug groups except for the cardiovascular agents, of which the consumption was constant. The proportion of subjects on regular drugs increased from 82% at 79 years to 95% at 88 years of age. Benzodiazepines were, at 88 years, used by almost 40% of the population; at the same age, 43% were using laxatives and 37% diuretics. Paracetamol (acetaminophen) was the most common analgesic used. Total consumption of drugs prescribed for hypertension decreased considerably, from 23 to 10%, despite an increase in the use of loop diuretics and vasodilating agents.

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