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Biomedical subjects

G Brown

Publications and source records attributed to G Brown.

At least 451 records · Page 25Linked to original sources
PubMed1976

Adaptation of a microimmunofluorescence test to the study of human Rickettsia tsutsugamuskh antibody.

A microimmunofluorescence (micro-IFA) test has been adapted to the study of naturally occurring antibody to Rickettsia tsutsugamushi in humans. The micro-IFA test was comparable to the present immlnofluorescent assay in sensitivity and reproducibility, but offered distinct advantages in the quantity of reagents necessary. Also the micro-IFA could be used to simultaneously titer a serum to as many as nine strains of the organism resulting in a great saving of time.

Antibodies, Bacterial↗
PubMed1975

Leukemia-associated antigens in man.

Rabbit antisera raised against acute lymphoblastic leukemia (ALL) cells were used to distinguish ALL from other leukemias, to identify rare leukemia cells in the bone marrow of patients in remission, and to define human leukemia-associated antigens. Antibody binding was studied with the use of immunofluorescence reagents and the analytic capacity of the Fluorescence Activated Cell Sorter-1 (FACS-1). The results indicated that most non-T-cell ALL have three leukemia-associated antigens on their surface which are absent from normal lymphoid cells: 1) an antigen shared with myelocytes, myeloblastic leukemia cells, and fetal liver (hematopoietic) cells; 2) an antigen shared with a subset of intermediate normoblasts in normal bone marrow and fetal liver; and 3) an antigen found thus far only on non-T-cell ALL and in some acute undifferentiated leukemias, which we therefore regard as a strong candidate for a leukemia-specific antigen. These antigens are absent from a subgroup of ALL patients in which the lymphoblasta express T-cell surface markers. Preliminary studies on the bone marrow samples of patients in remission indicated that rare leukemia cells were present in some samples. The implications of these findings with respect to the heterogeneity and cell origin(s) of ALL, its diagnosis, and its potential monitoring during treatment were discussed.

Absorption↗
PubMed1975

Personality and value orientations in early adolescence.

An analysis of the Psychoticism, Extraversion, Neuroticism and Lie scores of 674 13-year-old pupils in comprehensive schools revealed that they held specific relationships to six value orientations: Family Loyalty, Intolerance, Complacency, Passivity, Cynicism and Educational Primacy. These relationships are seen as pointing to an area which, by systematic investigation, would permit the psychology of personality and the sociology of values to be more closely integrated. The existence of three basic 'life orientations', 'Asocial', 'Unsocial' and 'Hypersocial', is suggested.

Adolescent↗