Search PubMed⌕ Search

Biomedical subjects

G Brambilla

Publications and source records attributed to G Brambilla.

260 records · Page 15Linked to original sources
PubMedDate not supplied

Splenic artery aneurysms in portal hypertension.

In a group of 170 cirrhotic patients with portal hypertension an 8.8% incidence of splenic artery aneurysm was found. These patients have been analysed. Attention was focused on the possible pathogenic mechanisms. On the basis of our experience, ligature and resection is considered the best treatment for large aneurysms. In nine patients a small sized aneurysm was left in situ in order to avoid splenectomy; none of these patients developed aneurysm rupture during a follow-up period from 6 to 48 months.

Adult↗
PubMedDate not supplied

[Contact dermatitis of the hands in housewives: the results of a multicenter study].

The survey was carried out between January 1988 and June 1990. It consisted in a clinical and allergological study of 1489 housewives, 880 of which had contact dermatitis at their hands. (group of "cases"). The other 609 represented the control group. The anamnesis was gathered with a guided questionnaire: the questions concerned familiar and personnel pathology, use of detergents and cosmetics, use of means of prevention and therapies. Patch tests with haptens of GIRDCA series and with the most common detergent components were performed. In 98% of cases hands were the lace of beginning of symptoms; in the group of "cases" 46% were positive to at least one patch test. Nickel sulphate gave positivities in the 28% of cases. Results of the search of this metal (and of chrome and cobalt) in detergents are described. Other possible occasions of contact are described. Other causes of sensitization are represented by rubber additives, by perfumes and by preservatives. Cutipositivities for detergents are very really limited. Means of protection, in particular barrier creams, are described as scarcely used.

Dermatitis, Contact↗
PubMedDate not supplied

Inhibition of the development of rat liver preneoplastic lesions by verapamil and dexverapamil.

The effect of verapamil and dexverapamil on the development of liver preneoplastic foci was investigated in male Sprague-Dawley rats initiated with N-nitrosodiethylamine (200 mg/kg i.p.), fed on a diet containing 0.01% 2-acetylaminofluorene and subjected to partial hepatectomy, according to the hepatocarcinogenesis model developed by Solt and Farber. Administration of drinking water containing 0.03% verapamil or dexverapamil resulted in a decrease in the incidence and size of gamma-glutamyl transpeptidase-positive foci. The chemopreventive effect of dexverapamil was more marked than that of verapamil. These findings support the hypothesis that these two calcium channel blockers act by reducing the resistance of initiated hepatocytes to the mitoinhibitory and cytotoxic effects of 2-acetylaminofluorene.

2-Acetylaminofluorene↗
PubMedDate not supplied

Alteration of complex IV and acetylcholine-related enzymes in experimental spinal cord injury.

Acute, severe injury of the rabbit spinal cord, induced by the weight-drop method, causes alterations of the enzyme activities related to cholinergic and energy metabolism. Morphological examinations at the trauma site show degenerative processes in neurons 0.5 hr posttrauma and a marked decrease in the number of living cells 24 hrs later. Both biochemical and cytochemical findings show that the tissue metabolic and morphologic derangement, caused by severe spinal cord injury, is mostly confined to the gray matter at an early stage (0.5 hr), whereas 24 hrs later the white matter is also involved. The decrease in choline acetyl-transferase and acetylcholinesterase activities in the gray matter parallels the impairment of complex IV (cytochrome c oxidase) of the respiratory chain and the presence of morphological alteration in neurons. The dramatic drop in the enzyme activities, observed 24 hrs after the induction of the severe trauma is clearly associated with the loss of cells.

Acetylcholinesterase↗
PubMedDate not supplied

Determination of chromium in feeds by automated microwave digestion and atomic absorption spectrophotometry.

Chromium, as trivalent organic form, has been recently proposed as feed additive to improve animal welfare and the quality-quantity of meat productions. To control its use in animal production we developed an analytical method that consisted of sample digestion by a commercially available focused microwave system and, subsequently, metal determination by graphite furnace atomic absorption spectrophotometry. The mineralization step was performed by treating the samples with a nitric acid-sulphuric acid-hydrogen peroxide mixture. Complete sample digestion was achieved in 26 min, as compared to 8-12 h or more required by dry ashing. To determine method accuracy and precision, we analyzed both feeds spiked at different Cr concentrations and a reference plant material. We found that mean metal recoveries ranged from 98.7 to 102.7% and for the reference material we obtained an excellent agreement between calculated and certified value. Quantitative Cr yields and relative coefficients of variation between 0.77 and 9.7% were very good and accounted for method accuracy and reliability. Finally, we applied the developed method to Cr analysis of some commercial feeds and the results were compared with those obtained by dry-ashing procedure.

Animal Feed↗