Phenomena of adaptation in rats continuously exposed to low concentrations of acrolein.
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Biomedical subjects
Publications and source records attributed to G Bouley.
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Holistic care of the critically ill includes meeting the needs of both the patient and the patient's family. The critical care nurse needs to be prepared to deal with the family's special needs during a time of crisis, including making decisions about the withdrawal of life support. This article addresses such issues, and includes care of the family once technological support has been withdrawn and the patient is transferred from the Intensive Care Unit.
A study of the effects of inhaled hair-spray was performed on 118 specific pathogen free male Wistar rats (71 test animals and 47 controls). Rats were exposed for 5 min, three times a day, five days per week, during one to eight weeks, in two plexiglas chambers, one for controls and one for test animals. The chambers were 20 1 in size, but only the noses of the animals were exposed to ambiant air or to a hair-spray aerosol polluted atmosphere. In the test chamber, the hair-spray was aerosolized for 30 s at the beginning of each exposure, using about 30 g of nebulized product. This hair-spray amount was high, although non-lethal (70% of DL0, 45% of DL50 and 26% of DL100). The hair-spray exposed rats exhibited significant modifications in the antixenic defence mechanisms of their respiratory system: diminished ciliary activity of the tracheal epithelium (-26%), increased number of harvested pulmonary macrophages (+52%), but decreased phagocytic ability of these cells (-8%). However we did not observe histologic differences in the respiratory system of exposed and control rats.
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