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Biomedical subjects

G Bonmarchand

Publications and source records attributed to G Bonmarchand.

At least 55 records · Page 3Linked to original sources
PubMed1987

[Diffusion of 5-fluorocytosine in bronchial secretions in patients with respiratory insufficiency].

The 5-Fluorocytosine bronchial secretion levels of 14 patients with a chronic respiratory disease were determined using a microbiological method. The mean maximal concentrations (7.76 +/- 7 micrograms/ml) were obtained at the end of a single 25 mg/kg i v perfusion over 30 minutes. The level increased when five i v perfusions were performed every 6 hours and bronchial diffusion was higher and faster by concomitant administration of (bromhexin hydrochloride). Therefore, 5-Fluorocytosine was not found in bronchial secretions of four patients in spite of a normal serum levels (21.5 +/- 5 micrograms/ml).

Bronchi↗
PubMed1986

Complete atrio-ventricular block after furosemide.

We report a case of nonfatal complete atrio-ventricular (A-V) block after injection of 125 mg of furosemide by a central vena cava catheter. Accidents with this diuretic are very rare but this observation shows that it could induce A-V conduction disturbances. When large quantities of this diuretic must be used, we would recommend a slow injection rate to avoid such accidents.

Aged↗
PubMed1986

[Drugs used in a medical intensive care unit].

The treatments of 400 consecutive patients admitted in a 22-bed adult medical intensive care unit (ICU) were analysed prospectively. One hundred and thirty-one different drugs were prescribed with a mean of 5 +/- 4 drugs per patient (means +/- SD), during 8 +/- 11 days. The most commonly prescribed drugs were 1) preventive drugs, 2) antibiotics, 3) psychoactive drugs and analgesics. Two-thirds of the drugs were administered by a parenteral route. Mean daily cost was low: 57 FF per patient (6.3 US dollars, 1984), most of this being due to the prescription of antibiotics (59.8%). The wide range of drugs prescribed in different ICU precludes the compilation of a restricted list of drugs to be used in ICU. Nevertheless, prescription guidelines are suggested consisting of the discussion, for each patient, of the prescription of any of four types of drugs: those of the organ failure(s), of the underlying disease(s), preventive drugs, and finally comfort drugs.

Adolescent↗
PubMed1985

Group R streptococci: wild boars as a second reservoir.

Group R streptococci have caused many cases of septicaemia and meningitis in patients handling live or slaughtered pigs which were the only known reservoir of group R streptococci. A human case, due to a wild boar, is reported here and it is therefore concluded that there exist both a domestic (pig) and a wild (wild boar) reservoir of group R streptococci.

Adult↗
PubMed1983

[Massive digestive hemorrhage in typhoid fever. A case report].

In a case of massive intestinal haemorrhage during typhoid fever the bleeding area was located by angiography to the superior mesenteric artery, and excision of the ileo-colonic junction was performed. Pathological study of the lesions showed necrosis of Peyer's plaques resulting in section of small submucosal arterioles. The necrosis itself was caused by initially endothelial lesions, later completed by thrombosis. The complication is exceptional. This case is reported in order to draw attention to the usefulness of mesenteric arteriography and the effectiveness of surgery in massive intestinal haemorrhages.

Colonic Diseases↗
PubMed1983

[Splenectomy and pneumococcal septicemia].

A literature review, following the observation of 4 cases of pneumococcal septicemia in splenectomized patients, demonstrated that infection was frequent in subjects with functional or anatomical asplenia, usually in the form of a pneumococcal septicemia. Infection occurs one hundred times more frequently in splenectomized patients than in the general population. The risk of developing an infection varies from one patient to another, and is related to the motive for splenectomy, the period since operation, and the age of the patient at the time of surgery. Pneumococcal septicemia in such cases is distinguished by its insidious nature and its very poor prognosis, the outcome being fatal in 50 to 70 p. cent of cases. This justifies intensive prophylactic measures: partial splenectomy, heterotopic transplantation, anti-pneumococcal vaccination, and long-term antibiotic therapy. None of these methods offers absolute protection, and indications for splenectomy should therefore be limited to the strict minimum.

Adult↗