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Biomedical subjects

G Boner

Publications and source records attributed to G Boner.

At least 127 records · Page 7Linked to original sources
PubMed1982

Is secondary hyperparathyroidism an important etiologic factor in the anemia of chronic renal failure?

Twenty patients with chronic renal failure being treated with hemodialysis were investigated in an attempt to ascertain whether hyperparathyroidism is an important etiologic factor in these patients' anemia. The patients were divided into two groups, one with hemoglobin of greater than 8 g/dl and the other with hemoglobin of less than 8 g/dl. These groups differed in blood transfusion requirements and in serum iron saturation. There was no difference between their levels of serum calcium, serum phosphate, serum alkaline phosphatase or serum parathyroid hormone. On bone biopsy endosteal fibrosis with bone marrow involvement was found in 2 of the 11 patients with high hemoglobin and in 5 of the 9 patients with low hemoglobin. Endosteal fibrosis with bone marrow involvement may thus be an important factor in the pathogenesis of anemia, and its presence or absence in association with hyperparathyroidism may explain the controversial observations reported by other investigators.

Adult↗
PubMed1982

Legionnaires' disease in Israel: a serological study of hemodialysis patients.

A serological survey was performed in three Israeli hospitals in order to evaluate the risk of nosocomial spread of the agent of Legionnaires' Disease or antigenically related organisms. Five out of 79 chronic hemodialysis patients had titers (1:512 to 1:2,048) of indirect immunofluorescence antibodies considered indicative of past infection. None of 44 healthy subjects, 37 ambulatory patients or 16 patients with acute gram-negative sepsis due to unrelated organisms showed a seroreaction of greater than or equal to 1:128.

Adult↗
PubMed1982

Nephrotic syndrome in the elderly.

Thirty-one patients who developed nephrotic syndrome when greater than 60 yr of age and who underwent renal biopsy are presented. In this group of the patients the most common histologic diagnosis was membranous nephropathy (52%); other diagnoses were amyloidosis (16%), end-stage renal disease (13%), chronic glomerulonephritis (9%), minimal change disease (6%), and lupus nephritis (3%). The prognosis in all these patients was poor; most of them died or were in terminal renal failure during the following-up period.

Aged↗
PubMed1982

Continuous ambulatory peritoneal dialysis- a new dimension in the treatment of end-stage renal disease.

Thirty-five patients treated with continuous ambulatory peritoneal dialysis (CAPD) were followed over a 2-yr period. Serum levels of protein metabolites were maintained at stable and satisfactory levels. Blood hemoglobin was higher during CAPD treatment than during hemodialysis. At the end of the follow-up period, 45.7% of the patients were still on CAPD, 25.7% of them had been transferred to another mode of dialysis because of complications, and 28.6% of the patients had died. In half of the latter, death was directly related to CAPD. The high incidence of peritonitis (one infection per 2.4 patient months) is the main drawback and reason for mortality in CAPD. Reduction in the incidence of peritonitis would make CAPD the preferred mode of dialytic therapy.

Adult↗
PubMed1981

Dialysis therapy for psoriasis. Report of three cases and review of the literature.

Three patients with psoriasis, who were resistant to all modes of accepted therapy, underwent 32 hours of peritoneal dialysis weekly for ten weeks. In two patients, there was a clearing of 80% of the psoriatic lesions after completion of therapy. In one of these patients, there was a recurrence of the lesions two months later, but the other patient is still in relative remission after 12 months. The third patient had clearing of 50% of the lesions, but there was recurrence two months after cessation of treatment. This experience as well as a review of the literature indicates that dialysis may have a positive effect on psoriasis and that the effect obtained is more prominent with peritoneal dialysis than with hemodialysis.

Adult↗
PubMed1981

Clearance of Tc-99m DTPA in hemodialysis and peritoneal dialysis: concise communication.

The clearance of Tc-99m DTPA was studied in 14 patients undergoing hemodialysis (HD) or peritoneal dialysis (PD). Mean Tc-99m DTPA clearance during HD was 37.8% +/- 10.1 of creatinine clearance. Mean Tc-99m DTPA clearance in PD was 65.1% +/- 10.3 of creatinine clearance. Tc-99m DTPA, with a larger molecular weight than that of creatinine, is cleared relatively better during PD than during HD. Thus Tc-99m DTPA may be used in the assessment of the effectiveness of different dialytic treatments for substances of similar molecular weight. In addition, our study shows that clearance of DTPA both in HD and PD is sufficiently high to allow the removal of this chelating agent in patients with renal failure.

Blood Flow Velocity↗
PubMed1981

The effects of proxazole on renal function in chronic renal failure.

3-alpha-Phenyl-propyl-5-beta-diethylaminoethyl-1,2,3-oxadiazole (proxazole), a spasmolytic papaverine-like agent, was i.v. administered to 13 patients with chronic renal failure (mean creatinine clearance 46.4 ml/min/1.73 m2), but did not improve renal plasma flow (p-aminohippurate clearance) or glomerular filtration rate (inulin clearance), nor did this agent prevent or modify nor-adrenaline induced renal ischemia. The oral administration of 400 mg proxazole (5.2--6.5 mg/kg/day) for a period of at least 90 days did not improve renal function in 11 patients with chronic renal failure. It is concluded that both i.v. and p.o. administration of proxazole in the dosages used is ineffective in improving renal function in patients with chronic renal failure.

Administration, Oral↗
PubMed1981

Fulminant spontaneous acute bacterial peritonitis in maintenance hemodialysis.

Two patients on maintenance hemodialysis therapy developed fulminant spontaneous acute bacterial peritonitis (S.A.B.P.). Both had positive blood cultures and died within a few hours despite intensive antibiotic and supportive therapy. No intra-abdominal source of the peritonitis was found in either case. Though septicemia is an important cause of death in the hemodialyzed patient, this form of presentation (S.A.B.P.) has not been previously reported.

Adult↗
PubMed1980

The shrinking man. A manifestation of severe renal osteodystrophy.

A 37-year-old man, who had been undergoing hemodialysis for nine years, had severe osteodystrophy with a consequent 28-cm locc in height. This shrinkage in size is probably secondary to tertiary hyperparathyroidism. In spite of two previous explorations, there is still evidence of hyperparathyroidism and his present condition precludes surgical intervention.

Adult↗
PubMed1980

Effects of pindolol on renal function.

Because beta blockers have been shown to reduce glomerular filtration rate (GFR), the renal effect of intravenous and prolonged oral administration of pindolol was examined in 10 patients with essential hypertension. Intravenous pindolol decreased inulin clearance from 99 to 94 ml/min/1.73 m2 (p < 0.005), and pulse rate from 75 to 69/min (p < 0.005). Blood pressure and filtration fraction were not changed. Oral pindolol (10 to 20 mg/day) for a mean of 6 mo resulted in a decrease in mean blood pressure from 124 to 111 mm Hg (p < 0.001), in mean pulse rate from 76 to 69/min (p < 0.005), and in mean plasma renin activity (PRA) from 0.9 to 0.29 ng/ml/hr (p < 0.05). Inulin clearance and filtration fraction did not change. At the end of oral therapy, intravenous pindolol induced a greater reduction in inulin clearance than in the first study. These observations indicate that intravenous pindolol induces a decrease in GFR probably secondary to hemodynamic effects. On the other hand, prolonged oral pindolol has no effect on GFR despite decreases in blood pressure, pulse rate, and PRA.

Adult↗
PubMed1980

Hemochromatosis in a renal transplant recipient.

A 47 year old kidney transplant recipient who died from liver failure caused by hemochromatosis, is described. The diagnosis was established by post mortem examination. The question whether these findings are an extreme form of the common pathological changes seen in the liver in other transplant recipients, or were related to infectious hepatitis or were due to the use of immunosuppressive therapy, remains unanswered.

Female↗