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Biomedical subjects

G Biagini

Publications and source records attributed to G Biagini.

At least 181 records · Page 10Linked to original sources
PubMed1981

Long term study of mesangial proliferative glomerulonephritis with IgM deposits.

Twenty-six cases of Mesangial Proliferative Glomerulonephritis and diffuse IgM deposits were studied. Nine had nephrotic syndrome; 8 minimal urinary abnormalities; 7 asymptomatic proteinuria; 2 recurrent haematuria. Immunofluorescence revealed granular mesangial deposits in 14 cases and interrupted linear deposits in the others, chiefly along the capillary walls. In the latter group the clinical picture was mainly nephrotic syndrome or asymptomatic proteinuria. The clinical course is favourable: 7 cases recovered; 12 improved; 7 did not show any change. No progression of renal lesions was observed. Despite uniform histological features, this nephropathy is unlikely to be a unique disease, but in our opinion it should be considered separately from other glomerulopathies.

Adolescent↗
PubMed1979

Skin storage in liquid nitrogen. An ultrastructural investigation.

The problem of cell survival as well as the biochemical and histological effects on skin of low temperature storage in liquid nitrogen has already received attention. However, little is known of the submicroscopic alterations induced by such treatment. Our study shows that rapid or slow freezing, direct or mediate contact with the liquid nitrogen, pretreatment before freezing, type and concentration of cryoprotectants, all have various effects on the fine morphology of epidermal cells. Glycerol is shown as having better cryoprotective activity than DMSO at concentrations of 15% or less. Our data are examined taking into account all available reports on the problem of cryopreservation and the use of cryoprotectants.

Dimethyl Sulfoxide↗
PubMed1979

Congenital dyserythropoietic anemia type II: serologic and morphologic family study.

A 29-year old woman with a history of chronic anemia, jaundice, and splenectomy was found to have congenital dyserythropoietic anemia type II (CDA II), based on the following: marrow erythroid hyperplasia, abundance of binucleated erythroblasts, electron microscopic evidence of double membranes lining the cell membrane, erythrocyte lysis in the acidified serum test, erythrocyte agglutination and lysis by anti-i antibodies. Three healthy relatives (mother, father, and brother) of the patient had marrow erythroid hyperplasia and a percentage of binucleated erythroblasts that was higher than normal. A structural alteration of the nuclear membrane was detected in some of their erythroblasts. Furthermore, the erythrocytes of the father and the brother were agglutinated by anti-i antibodies. This observation is consistent with a recessive mechanism of inheritance, and suggests that heterozygosity for CDA II can be somatically expressed at different levels.

Adult↗
PubMed1977

[Electron microscopy features of renal changes in chronic lead poisoning (author's transl)].

The Authors report the results of a renal morphological study carried out on eight patients with chronic lead poisoning. The ultrastructural analysis showed changes, mainly involving the proximal tubules, as follows: 1) degenerative pattern (swollen mitochondria, dilated endoplasmic reticulum and scanty microvilli); 2) signs of metabolic hyperactivity (intranuclear granular inclusions, odd shaped nuclei); 3) regenerative pattern (poorly differentiated cells with few microvilli, shallow infoldings of basal cell membranes). In the glomeruli the most characteristic finding was a mesangial reaction. The basement membrane, in some cases, appeared to be thickened and the visceral epithelial cells hypertrophic. Interstitial fibrosis was present, as well as, occasionally, a certain degree of arteriolar hyperplasia. These data appear to confirm that chronic lead nephropathy has an extremely slow evolution.

Adult↗
PubMed1976

Dermal vessels in acrodermatitis chronica atrophicans.

An ultrastructural investigation of two patients suffering from acrodermatitis chronica atrophicans revealed in the small dermal vessels swelling of the endothelial cells, material of probably plasmatic origin accumulated in the subendothelial area, and sleeves of basement membrane-like material on a concentric perivascular layout.

Acrodermatitis↗
PubMed1975

An electron microscope study of Darier's disease.

An electron microscope investigation was performed on cutaneous biopsies from four patients with Darier's disease. Suprabasal lacunae with acantholytic cells a prominent feature. Basal cells and acantholytic cells showed an increase in tonofilaments. Corps ronds appeared as vacuolated cells.

Acantholysis↗
PubMedDate not supplied

Basement membrane production by hepatocytes in chronic liver disease.

The immunohistologic distribution of fibronectin, laminin, type IV collagen and whole basement membrane was evaluated in liver biopsies from patients with chronic active liver disease. Fibronectin was consistently increased in the areas of piecemeal necrosis, portal tracts and fibrous septa. Laminin was not detected in normal liver parenchyma. In contrast, laminin positive linear basement membrane structures were prevalent in portal tracts, fibrous septa and the peripheral sinusoids of cirrhotic nodules. In areas of piecemeal necrosis, the hepatocytes, single or assembled in "rosettes", were frequently underlined by linear deposits of laminin and type IV collagen. This immunoreactivity was often polarized, being confined to the stromal side of liver cells, while the parenchymal side was negative for both proteins. Electron microscopy revealed a typical basement membrane in corresponding areas. Hepatocytes normally do not produce a basement membrane, but do so following chronic injury. We suggest that the polarized basement membrane accumulation by hepatocytes is a hallmark of hepatocyte regeneration following damage.

Basement Membrane↗