With the aid of a computer graphic display technique, data gathered from exploratory diencephalic recordings in 130 stereotactic operative procedures are presented to show the differing topographical distribution of 'joint'- and 'muscle'-evoked cellular activity. In addition, the variable position of these responses in relation to common diencephalic landmarks is presented. Our findings indicate that response points lie in a sickle-shaped zone 14-19 mm lateral to the midline and 2-11 mm posterior to the midcommissural plane. This area correlates closely with the findings of others on the thalamic zone of 1A afferent projections and agrees with the anatomical position of the nucleus ventralis intermedius as plotted by others. When the response points are plotted against a common posterior commissure, a more compact grouping is obtained and 'muscle'- and 'joint'-evoked responses are noted to separate into different zones, with 'muscle' responses positioned slightly anterior and inferior to those for 'joint'. Somatotopographically, face responses were positioned posteriomedially and leg responses anterolaterally.

Afferent Pathways↗

PubMed1980

Topography of 'bilateral-movement-evoked' thalamic cellular activity found during diencephalic recording.

With the aid of a computer graphic technique, data gathered from exploratory diencephalic recording in 130 stereotactic procedures are presented to show the topography of 'bilateral-movement-evoked' thalamic cellular activity. Thalamic cells responding to bilateral voluntary extremity movement were found to occupy a thalamic zone rostral to the zone for 'muscle'- and 'joint'-evoked thalamic cellular activity.

Adolescent↗

PubMed1980

Organization and topography of sensory responses in the internal capsule and nucleus ventralis caudalis found during stereotactic surgery.

With the aid of a computer graphic technique, data gathered from exploratory stimulation of the diencephalon in 130 stereotactic operative procedures indicate that some sensory fibers in the capsule are parallel to motor fibers at basal thalamic levels and occupy a position medial to motor fibers. In addition, stimulus responses which probably represent thalamocortical projections from S II somesthetic thalamus were found to lie in a capsular zone rostral to the motor bundle. The organization of S I somesthetic thalamus was found to agree with the previous finding of Tasker et al. and some of these fibers project within the motor bundle to cortical motor areas.

Adolescent↗

PubMed1980

[Benign nevus cells in lymph nodes. Case report (author's transl)].

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Adenocarcinoma↗

PubMed1979

Studies on the cytodynamics of human endometrial regeneration. III. In vitro short-term incubation historadioautography.

The proliferation kinetics of endometrial regeneration were assessed by tracing nucleoprotein precursor, radiothymidine. Increased isotope uptake occurred by cycle day 3 and was confined to the gland cells of denuded stratum basale (basal layer) and persistent uterine lining, bordering peripheral areas of denudation. This increase resulted in the formation of flattened surface epithelial cells, which initially were devoid of significant deoxyribonucleic acid synthesis. Such alterations are consistent with changes in cells involved in ameboid migration. Maturation of migrating cells was accompanied by a significant rise in labeling indices and replication at cycle days 3 and 4. By cycle day 5, endometrial repair was complete. The findings indicate that, following physiologic loss of stratum functionale, endometrial healing involves both migration and replication of surface cells, which originate from the gland stumps of the residual basal layer and the persistent surface epithelium adjacent to the periphery of denuded endometrium.

Adult↗

PubMed1979

Proliferation kinetics of human endometrium during the normal menstrual cycle.

A radioautographic analysis of the number and distribution of labeled nuclei after in vitro incorporation of radiothymidine was carried out in human endometrium during the normal menstrual cycle. The highest rates of proliferation were recorded on cycle days 8 to 10 in the upper one third of the functionalis layer. Coinciding with intraglandular secretory activity on cycle day 19, the rate of proliferation of gland cells decreased near zero levels and remained unchanged thereafter. Midsecretory phase arteriolar coiling and stromal predecidualization were associated with increased isotope incorporation. DNA synthesis in premenstrual endometrium was limited to the surface epithelium, predecidua, and vascular endothelium. The endometrium of the isthmus and cornual regions and of the basalis zone demonstrated relatively constant and comparatively lower rates of proliferation throughout the cycle. Regional and cellular variations in nucleic acid synthesis in cyclic endometrium are likely to reflect differences in physiologic functions in target cells in response to cyclic hormonal stimuli.

Adult↗

PubMed1979

Divorce and remarriage in a 65-year-old male following transphenoidal surgery and bromocriptine of hyperprolactinemic impotence: a dilemma.

Hyperprolactinemia, hypogonadotropinism, and subnormal plasma testosterone were found in a 65-year-old patient who had an enlarged sella turcica, complained of fatigue, and addmitted to decreased sexual interest and potency. Selective nontotal tumorectomy followed by bromocriptine therapy resulted in normoprolactinemia, increased plasma testosterone, and "rejuvenation difficult to follow" according to his wife. This patient described his sexual status as comparable to that of age 24 when he fathered his only child. Both wife and husband attributed the changes to bromocriptine and requested discontinuation (wife) and continuation (husband) of the treatment; because of the clinical indications, treatment was continued. Legally, a medical certification of a normal state of health was required before divorce--and subsequent marriage to a young woman--were permitted.

Bromocriptine↗

PubMed1979

The position and organization of motor fibers in the internal capsule found during stereotactic surgery.

Data gathered from exploratory stimulation of the diencephalon in 130 stereotactic operative procedures have been studied, with the aid of a computer graphic technique, to show the position and topography of motor responses in the internal capsule. The results obtained indicate that pyramidal fibers are organized into a rostral-caudal face-arm-leg sequence and occupy a short compact band in the caudal third of the posterior limb of the internal capsule. This is in contrast to previous concepts of the position of these fibers in the capsule.

Adolescent↗

PubMed1979

Position of the medial internal capsular border in relation to third-ventricular width.

The position of the medial internal capsular border (lateral thalamic border) in relation to the width of the third ventricle is of considerable importance to stereotactic surgeons. Close estimation of its position from anteroposterior roentgenograms diminishes the possibility of multiple brain penetrations in an attempt to find it by electrophysiological methods. By correlating the position of the medial capsular border found by a stimulation technique, with the width of the third ventricle, in a series of 130 patients, reliable ranges of its position were obtained.

Adolescent↗

PubMed1979

Thalamic recordings during stereotactic surgery. I. Surgery topography of evoked and nonevoked rhythmic cellular activity.

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Adolescent↗

PubMed1979

[Erythema gyratum repens (Gammel's syndrome)].

A case of erythema gyratum repens is reported in 78 year old woman. The particularly typical eruption, mainly affecting the trunk, was associated with a squamous cell carcinoma of the esophagus. The paraneoplastic dermatosis cleared after radiotherapy of the cancer.

Aged↗

PubMed1979

Thalamic recordings during stereotactic surgery. II. Location of quick-adapting touch-evoked (novelty) cellular responses.

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Adolescent↗

PubMed1978

Pituitary hyperthyroidism. Case report and review of the literature.

A 58 year old woman with an enlarged sella turcica was found to have hyperthyroidism with a supranormal concentration of serum thyrotropin. Transsphenoidal microsurgery resulted in the removal of a chromophobe adenoma comprised mainly of thyrotropes. Postoperatively, serum thyrotropin, thyroxine and triiodothyronine levels fell within normal limits, and the patient maintained normal thyroid and pituitary function.

Adenoma, Chromophobe↗

PubMed1978

Acromegaly and galactorrhea-amenorrhea with two pituitary adenomas secreting growth hormone or prolactin. A case report.

A prolactinoma was removed from a nulliparous woman who had acromegaly, galactorrhea-amenorrhea, elevated serum growth hormone and prolactin, and hypogonadotropinism. Postoperatively galactorrhea decreased and cyclic vaginal bleeding ensued; serum prolactin concentration was normal but growth hormone remained elevated and the acromegalic complex was unchanged, even after subsequently administered bromocriptine. At a second transsphenoidal operation, an adenoma of somatotropes was removed; improvement in symptoms and signs and normalisation of pituitary function, including growth hormone, followed. The possible presence of distinctly separate pituitary adenomas should be considered in patients with galactorrhea associated with acromegaly.

Acromegaly↗