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Biomedical subjects

G Bertrand

Publications and source records attributed to G Bertrand.

At least 127 records · Page 7Linked to original sources
PubMed1985

Stereotactic system and apparatus for use with magnetic resonance imaging, computerized tomography, and digital subtraction imaging.

A light-weight nonmagnetic, nonconductive instrument has been devised for use with magnetic resonance imaging, computerized tomography, and digital subtraction imaging for work in the field of epilepsy, brain tumors and vascular lesions. The apparatus' main characteristic is its ability to use optionally either the lateral orthogonal or the spherical-radial approach.

Brain Neoplasms↗
PubMed1985

Tension pneumocephalus after evacuation of chronic subdural hematoma and subsequent treatment with continuous lumbar subarachnoid infusion and craniostomy drainage.

We present a case of tension pneumocephalus after burr hole evacuation of bilateral chronic subdural hematomas. Subsequent treatment was effected with combined twist drill closed system drainage and continuous intrathecal infusion of a physiological solution. The clinical entity, tension pneumocephalus, and the use of continuous subarachnoid infusion and drainage as a method of cerebral reexpansion are discussed.

Aged↗
PubMed1985

[Efficacy of ranitidine and cimetidine in the treatment of gastric or duodenal ulcer resistant to an initial treatment with cimetidine. Multicenter controlled therapeutic trial].

In a controlled clinical trial conducted in 28 centers, 354 ambulatory patients with a cimetidine-resistant duodenal or gastric ulcer (at least six weeks of treatment at a dose of 1 g/day) confirmed by endoscopy were allocated at random to either ranitidine or cimetidine treatment: 166 patients received cimetidine (1.6 g/day in 4 oral doses), and 188, ranitidine (0.3 g/day in 2 oral doses). The two groups differed significantly with regard to sex and history of gastrointestinal hemorrhage but not with regard to age, weight, history of peptic disease, history of perforated ulcer, duodenal/gastric ulcer ratio, number of smokers and alcohol consumers. The criterion of effectiveness was endoscopic healing of the ulcer after six weeks of treatment; in case of doubt, vital staining with methyl blue was performed. A significant difference was observed between the results of the two treatments in the duodenal group (p less than 0.05) but not in the gastric group, the healing rates being respectively 71 p. 100 and 65 p. 100 with ranitidine, and 59 p. 100 and 44 p. 100 with cimetidine. Twelve patients developed side-effects with a highly significant difference between the two groups: 11 patients under cimetidine and one patient under ranitidine (p less than 0.001). These results show the effectiveness of ranitidine as a complementary treatment in cimetidine-resistant peptic ulcers of duodenal location.

Adult↗
PubMed1985

[Fibroadenoma of the paraurethral glands. Immunohistochemical study].

A sub-urethral tumour presenting the architecture of a fibroadenoma and of which the tubular structures were lined with a transitional type epithelium, was described under the term of fibroadenoma of the para-urethral glands. The immunohistochemical study described contributes to bring supplementary arguments in favour of this hypothesis, in showing the presence of numerous argyrophil cells, rich in serotonin, as well as some cells marked by an anti-prostatic acid phosphatase serum. We noted also, with surprise, the presence of some rare cells stained by the anti-calcitonin serum.

Adenofibroma↗
PubMed1985

[Developmental bilharziasis caused by Schistosoma mansoni discovered 37 years after infestation].

The authors report a case of Mansoni Schistosomiasis whose course in always running thirty-seven years after the first and alone infestation in a fifty-six old man who come back from Madagascar in February 1948 and lives in France since this period eggs of schistosomiasis were living in a biopsy of rectal and sigmoid mucosea. Problem of adult worms longevity and clinical importance of such prolonged inapparent schistosomiasis are discussed.

Humans↗
PubMed1985

[Chronic pain and syringomyelic slit of the posterior horns of the spinal cord].

Two male patients 46 and 44 y.o. respectively, were admitted for a syndrome of chronic pain characterized by: sudden onset, spontaneous or following spasmodic coughing, of an anterior hemithoracic pain slowly progressing to involve several unilateral cervicothoracic dermatomes, a continuous burning sensation made worse by light touch, limb movements and cold water, and partially relieved by warm water or deep palpation. On examination, patient 1 revealed no sensorimotor deficit after repeated observations during 8 years. At autopsy, a syrinx localized at the cord segments corresponding to the symptoms was found without documentation of specific causal factors. It involved the posterior horn of the cord selectively. In patient 2, pain was associated with slight hypesthesia to pinprick and heat from C2 to T5 on the left without motor deficit since 18 months. A high resolution C.A.T. scan showed an intramedullary cavity 0.3 cm from the midline in the projection of the posterior horn without anomalies at the cervicomedullary junction. These observations link chronic pain syndromes with predominantly posterior horn lesions, which so far have failed to respond to conventional therapeutic measures.

Adult↗
PubMed1985

[Prostatic carcinoma: histoprognosis, prognostic value of Gleason's index].

This paper recalls the definition of the Gleason index and describes the five architectural types that enable a calculation of the index. The conditions of the practical application of the index are defined, with a discussion of reproducibility of results based on current literature and the author's experience. The index allows appreciation of the developmental potential of prostatic cancer and distinguishes between patients with a high risk of metastases and death from the cancer and those with low potential development. While the Gleason index cannot predict the course of the tumour in any given patient, it can be considered a useful element among the clinical and biological factors assessed in the prognosis of prostatic carcinoma.

Adenocarcinoma↗
PubMed1984

Comparative flow DNA analysis of different cell suspensions in breast carcinoma.

This study compared three methods of dissociation of breast lesions for DNA flow cytometry. Eleven benign lesions and 66 cancers were dissociated using mechanical, Ficoll, or enzymatic methods. DNA flow analysis showed that the DNA index did not vary from one method of dissociation to another. All benign lesions were diploid and 67% of all cancers were aneuploid. Enzymatic dissociation gave a lower percentage of aneuploid cells with a diminution of the proportion of cells in the G2 + M phase (13.2% enzymatic against 17.6% Fi-coll); on the other hand, it provided cell populations of greater viability than the other methods (32.6% enzymatic, 17.2% Fi-coll; P less than 0.01). The mechanical and Ficoll suspensions did not differ significantly when they were analyzed on the basis of their DNA content and their cellular viability. When compared with mechanical preparation, Ficoll suspension showed a lower recovery of tumor cells, but this inconvenience was compensated for by a more homogeneous aspect where the contribution of aggregates and debris was clearly lessened. Therefore, this study led us to choose Ficoll suspension for subsequent flow analysis of breast tumors.

Adult↗
PubMed1984

The hemi 3 syndrome. Hemihypertrophy, hemihypaesthesia, hemiareflexia and scoliosis.

Three unrelated girls presented with a developmental syndrome of hypertrophy involving half or a quadrant of the body and not involving the face. The appearance was one of inappropriately large size of the affected side rather than contralateral atrophy. On the larger side, there was hypertrophy of muscle and increased power as well as an increase in diameter, but not in length, of long bones. There was areflexia and decreased pain and temperature sensation on that side. The patients also had progressive scoliosis and foot deformities on the enlarged side. One patient had a lumbar myelomeningocoele , and all 3 had a family history of neural tube closure defects. EMG, nerve conduction studies, EEG, skull x-rays, PEG, and cerebral CT scans were normal. Myelography did not demonstrate an enlarged cord, and in particular there was no evidence for syringomyelia. Chromosome studies revealed normal karyotypes. Sex chromatin was female on both sides in one patient. A defect of the dorsal lip of the neural tube or the neural crest is postulated to explain the abnormality. The association with closure defect in one patient and a positive family history of other neural tube defects in all 3 patients suggests that the developmental defect occurs at an early embryonic stage. Recognition of the syndrome is important. It can be distinguished clinically from hemiatrophy of cerebral origin. The neurological abnormalities are static, but the scoliosis is progressive and requires correction. The condition is associated with an increased prevalence of neural tube closure defects in the family, and forms part of a spectrum of genetically and embryologically related CNS malformations with multifactorial inheritance. Probands, parents, siblings and parents' siblings should be counselled that the risks of spina bifida and anencephaly in their offspring are the same as those in relatives of probands with classical neural tube defects, and should be offered prenatal diagnosis.

Adult↗