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Biomedical subjects

G Bernaschek

Publications and source records attributed to G Bernaschek.

At least 163 records · Page 9Linked to original sources

[The betamethasone test in the diagnosis of placental insufficiency].

A trial to evaluate a functional test of the fetoplacental unit by measuring the extent of suppression of maternal estriol serum levels by glucocorticoids is described. 21 women between the 30th and 40th week of gestation received 4 mg betamethason intravenous injection at 8.30 a.m. Blood samples were collected immediately before betamethason application and at 1.00 p.m., 4.00 p.m., 8 p.m. o'clock and at 8.30 a.m. on the next day. Estriol (E3), cortisol, dehydroepiandrosterone sulfate (DHEA-S) and human placental lactogen (HPL) were determined from serum samples by radioimmunologic methods. Patients were divided into 3 groups: severe placental insufficiency (group I, n = 6) described by growth retardation of the fetus of more than 2 weeks, normal gestations (group II, n = 8) and slight growth retardation (group III, n = 7). After temporary suppression in groups II and III, E3, DHEA-S and cortisol levels showed a significant increase the day after betamethason. In group I an increase of these parameters was observed 2 to 5 days after betamethason. These results show that a low intravenous dosage of betamethason and collection of blood samples for E3 assays in intervals of 12 hours can be used as a functional test of the fetoplacental unit.

Betamethasone↗

Prediction of the date of delivery during late pregnancy.

In 217 patients with unknown gestational age prediction by echographic demonstration of the upper tibial and the lower femoral centre has been compared with the biparietal diameter. Echographic demonstration of epiphyses in the fetal knee area have made it possible to obtain at the end of the pregnancy again more exact values. Particularly favourable results are achieved in the presence of tibial epiphysis, whereby the prediction of term shows a mean deviation of +/- 7.8 days, and a standard deviation of 10.6 days.

Age Determination by Skeleton↗

Heat flux from the fetal scalp during labor and fetal outcome.

In 40 deliveries a new variable, heat flux from the fetal scalp, was recorded and correlated with fetal outcome. The heat flux from the fetus, which reflects the temperature gradient between the warmer fetus and the mother was measured by a transducer attached to the fetal scalp after rupture of the membranes. In the last 20 min before delivery we found a statistically significant correlation (p less than 0.05) between heat flux from the fetus and pH of umbilical artery blood. Heat flux in the group with higher pH differed significantly from those with lower pH. We conclude that heat flux measurements could be developed and used for fetal monitoring.

Body Temperature↗

[Lymphatic cysts after radical abdominal surgery--epidemiology and aetiopathogenesis].

In the last ten years have been 8 cases of lymphatic cysts among 225 regularly controlled patients after Wertheim's operation. There is a significant difference between a control group with and one without resection of the Rosenmüller's node, in addition to an obligatory extirpation of lymphatic nodes. The significance of this lymphatic node for the genesis of lymphocysts is supported by the localisation of small cysts in ultrasonography. The influence of other factors on the genesis of lymphocysts is discussed in our own cases and in those of the available literature.

Cysts↗

[Method for recording the parametrical situation in cases of carcinoma of the cervix uteri].

The degree of parametrical infiltration in cases of carcinoma of the cervix uteri could until now be judged by palpation only. Special ultrasound examinations with rectal scanners should be beneficial in future for the recording of the parametrical situation. Although it is not possible to differentiate between inflammatory and cancerous infiltration with this new method, additional punctures under echographic control could be of great value.

Adnexa Uteri↗

[Modification of echographically detectable epiphyseal centers by the sex, weight and length of the fetus].

An investigation on the influence of foetal factors on the size and the appearance of epiphysis centres in the foetal knee is performed in 222 cases with well-defined duration of amenorrhoea. While the weight and the length of the infants show a significant influence at least on the size of the femoral centres, sex does not have any influence on the diameter. The time of the echographic appearance of epiphysis centres does not depend on any of the investigated foetal parameters.

Age Determination by Skeleton↗

[Surgery or radiotherapy for cervical carcinoma stage IIb].

134 cases of cervical cancer of the clinical stage IIb were examined with regard to the five-year survival rate. The report covers the time from 1964 to 1976. The patients had either been operated on primarily or had primarily undergone irradiation treatment. The five-year survival rates for the first group amount to 57.69% (n = 78), for the second group to 42.86% (n = 56). This difference is not significant under the restriction of limited comparability because of the different age of the patients. 65.38% (abs.: 51 from 78) of the operated cases turned out to be clinically overestimated cases of cervical cancer of the histological stages Ib, Ic and IIa. 27 cases belonged to the clinical and histological stage IIb and for this group of patients the five-year survival rate was 29.62% only. This and a number of other factors--the narrowing of the site of the operation with the growing danger for the ureter, increasingly affected lymphatic nodes--would justify restraint concerning surgical treatment of stage IIb.

Adult↗

[Etiology of uterine prolapse].

From the factors known to promote descensus those which may best be objectified--among them overweight, hard physical labour, weakness of the connective tissue and number of births--are examined in a group of women with descensus and a control group with regard to their valence for the development of a descensus. Log-linear models are applied in the calculation of qualitative variables. According to that, overweight means a fourfold, hard physical labour a threefold, weakness of the connective tissue a 2,7-fold and birth of more than one child a 2,2-fold risk of descensus.

Adult↗

[Uterine prolapse after episiotomy].

The value of episiotomy in regard to the prevention of descensus vagina et uteri is examined in a statistically reliable number of patients (64 cases). Women who were delivered without episiotomy provided the control group (70 cases). In both groups factors promoting pelvic relaxation were taken into consideration. According to the results of this examination the importance of episiotomy as prophylaxis of pelvic relaxation does not justify any obligatory use.

Episiotomy↗

[SP-1 in normal and complicated early pregnancy. Diagnosis by enzyme immunoassay].

Pregnancy specific glycoprotein SP-1 was measured by enzyme immunoassay Enzygnost in patients with diagnosis of haemorrhage in early pregnancy. Results were compared with a normal range between 6.-22. week of gestation (n = 268) and were analysed for their predictive value in determining prognosis. 24 of 27 cases with levels below the normal range had an abortion (88,9%) while 28 of 31 women with continuing pregnancies had levels within normal range (90,3%).

Abortion, Spontaneous↗

[The position of the uterus in vivo (author's transl)].

Version, flexion and position of the uterus was checked by sonography in 152 women. In contradiction of the common opinion that anteflexion is usually combined with anteversion, only 20.3% of the women showed a marked bend between the axes of the corpus and cervix. Retroflexion was observed in nearly all cases of retroversion. With regard to lateroversion, a significant inclination of the uterus to the right was seen in women with anteversion (60.9%), whereas the opposite trend was observed with the retroverted uterus.

Female↗

[Bladder dysfunction in pregnancy (author's transl)].

105 primiparous and 125 multiparous women have been asked for complaints of incontinence during their pregnancies. Multiparae suffered more often from stress incontinence, nullips reported a higher rate of urgency. The reasons and the influence of episiotomy, operative deliveries (forceps and vacuum) and pelvic floor training on incidence and recurrency of urinary incontinence during pregnancy are discussed.

Adult↗

[A new echographic method for the determination of the ossification centres in the fetal knee (author's transl)].

A method is described, which permits the determination of fetal maturity by ultrasonic measurement of the ossification centres. This method provides the same data as the x-ray examination without any irradiation and even at an earlier stage of pregnancy. The technique to determine the lower femoral and the upper tibial centre is explained and the advantages of this ultrasonic method for determination of fetal maturity are discussed.

Bone Development↗

[Echographic investigation of the calyceal system in cases of pyelitis gravidarum].

Dilatation of the upper urinary tract can be found even in pregnancies of healthy women. The frequency of dilatations in patients with pyelitis gravidarum is higher. Comparing the symptoms -- costovertebral tenderness and significant bacteriuria -- with the nephrosonograms it can be demonstrated that urinary tract infections incline to reoccur in patients with dilated upper urinary tract despite adequate antibiotic therapy. Echographic examination of the calyceal system during pregnancy might therefore be useful in detecting risk patients who have to undergo intense urologic surveillance.

Adolescent↗