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Biomedical subjects

G Bernard

Publications and source records attributed to G Bernard.

At least 73 records · Page 4Linked to original sources
PubMed1985

Cerebral blood flow and blood-brain influx of some neutral amino acids in control and hypothyroid 16-day-old rats.

Rats were made hypothyroid by a daily subcutaneous injection of propylthiouracil beginning the first day after birth. CBF, brain plasma volume, blood-brain extraction, and influx of some neutral amino acids were studied in 16-day-old animals. In hypothyroid rats, the brain plasma volume was decreased by approximately 30%. CBF was decreased by greater than 50%. This decrease was the highest in cerebellum. Blood-brain extraction of small neutral amino acids (alanine, serine, cysteine) was greatly enhanced. This greater extraction compensated for the decreased supply of alanine brought about by its decreased plasma concentration and the lower CBF. In contrast, the extraction of the large amino acids tested (leucine, phenylalanine) was hardly increased, and the influx of phenylalanine was slightly decreased. These results suggest an alteration in the maturation of the brain capillary bed and capillary transport for neutral amino acids in hypothyroidism. The differential effect of hypothyroidism on some small and large amino acids is an additional argument for the existence of two systems of transport for neutral amino acids at the luminal membrane of brain capillary endothelial cells of immature rats.

Amino Acids↗
PubMed1983

Regressive or lethal lead encephalopathy in the suckling rat. Correlation of lead levels and morphological findings.

Lead encephalopathy was produced in immature Sprague-Dawley rats with an intraperitoneal (IP) injection of 60 micrograms/g body weight of lead acetate administered daily from the fifth day after birth. Macroscopic and light microscopic study of the nervous system, estimations of the blood-brain barrier permeability to proteins and brain water content were performed every two days thereafter. Lead levels in total blood, plasma, and several brain areas were measured at the same intervals by flameless atomic absorption spectrometry. Electron microscopic study of the cerebellum was done 2, 6, and 12 days after beginning lead administration. After two days of lead administration and before any pathological change occurred the increase in lead level was greater in the cerebellum than in other brain areas. After four to six days, hemorrhagic lead encephalopathy developed and was most prominent in regions with higher lead levels. From day 11 to 14, there were two possible courses: a) improvement of the clinical status and morphological findings in 25% of the animals, or b) progression of abnormal clinical signs and death. Cerebral edema, both intra- and extracellular, may have contributed to the fatal evolution. The mechanism of this edema appeared complex and may have involved resorption failure. Good correlations were observed among progression of the clinical signs, high water content in the brain, morphological evidence of cerebral edema, and a high cerebellar lead level. In contrast, high blood lead levels could be associated with clinical improvement, normal brain water content, and regression of the pathological findings. These data suggest that differences in evolution are more likely related to differences in the development of resistance of the cerebral capillary to lead, or in the efflux of lead, rather than to the blood lead concentrations.

Animal Population Groups↗
PubMed1983

An economic analysis of the illicit drug market.

Analyses of heroin addiction have often focused on its relationship to crime. It is assumed that with an increase in price, the addict who has a dependence must commit crime to support his habit. The present analysis proposes a new and critical approach to the problem based upon Consumer Behavior Analysis. It identifies the variables of Complements and Substitutes, and their effects upon price, supply and demand, criminality, and possible implementation of treatment modalities.

Drug Tolerance↗
PubMed1978

[Local synthesis of immunoglobulins in pleural effusions. II].

A report is given about the synthesis of IgG immunoglobulins in the pleural infiltrations. The quantity of immunoglobulins locally yielded is estimated through the ratio IgG/Albumin in the blood and in the infiltration. Evidence is given that the mechanic and neoplastic transudates are easily detectable on account of the failed local synthesis of immunoglobulins of IgG type. A short account is given of the local synthesis of IgA.

Humans↗
PubMed1977

Clioquinol.

Explore the source record for details and available documents.

Benzoates↗
PubMed1977

[Advantages of the combination of the technics of double arc precipitation analysis and of scaled dilutions in the study of asymptomatic monoclonal gammopathies].

A report is given about the opportunity and the advantages of combining the traditional scheme for the study of the pathological immunoglobulins with the analysis of the uncoupling of the bow of precipitation against IgG and the isolation of the pathological immunoglobulin through a diluition of the serum such as to bring the fraction electrophoretically dispersed to not detectable levels and make it detectable the monoclonae portion electrophoretically homogeneous.

Humans↗
PubMed1966

[Treatment of vaginal moniliasis during pregnancy with a new biologic antifungal agent: pimaricin].

Pregnancy creates conditions which favour the development and persistence of candidiasis (moniliasis). The resultant vaginitis is often refractory to treatment. A new fungicidal antibiotic, pimaricine (Pimafucine), was studied in 91 women with vaginal moniliasis, all of whom were pregnant. Fifty-six (63%) were cured on the basis of negative cultures and 28 became symptomfree in spite of positive cultures. In this series, 94.3% benefited from treatment.

Anti-Bacterial Agents↗