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Biomedical subjects

G Berge

Publications and source records attributed to G Berge.

At least 19 recordsLinked to original sources
PubMed2004

Analysis of resveratrol as a lung cancer chemopreventive agent in A/J mice exposed to benzo[a]pyrene.

Resveratrol inhibits PAH bioactivation through reduced expression of the CYP1A1 and CYP1B1 genes in human bronchial epithelial cells. Ad libitum access to a diet containing resveratrol showed no effect on benzo[a]pyrene-induced lung tumorigenesis in A/J mice. Also, resveratrol did not change CYP1A1 and CYP1B1 gene expression or benzo[a]pyrene protein adduct levels in the lung tissue. The lack of chemopreventive activity may have been caused by insufficient concentrations or nonreactive forms of resveratrol in the lungs.

Angiogenesis Inhibitors↗
PubMed2004

Resveratrol inhibits benzo[a]pyrene-DNA adduct formation in human bronchial epithelial cells.

Resveratrol (trans-3,4',5-trihydroxystilbene), a phytoalexin present in various plants and foods, has in several in vitro and in vivo studies demonstrated cancer chemopreventive and chemotherapeutic potential. We investigated the in vitro effect of resveratrol on benzo[a]pyrene (B[a]P) -induced DNA adducts in human bronchial epithelial cells. This was compared to the effect of resveratrol on the expression of the cytochrome P450 (CYP) genes CYP1A1 and CYP1B1 and the formation of B[a]P metabolites. Exposure of BEAS-2B and BEP2D cells to B[a]P and increasing concentrations of resveratrol resulted in a dose- and time-dependent inhibition of DNA adduct formation quantified by (32)P-postlabelling. Supporting this result, resveratrol was shown to inhibit CYP1A1 and CYP1B1 gene expression, as measured by real-time reverse transcriptase-polymerase chain reaction. Also, a significant correlation was found between the number of DNA adducts and the mRNA levels of these genes. Using HPLC analysis, a concomitant decrease in the formation of B[a]P-derived metabolic products was detected. In conclusion, these data lend support to a chemopreventive role of resveratrol in polycyclic aromatic hydrocarbon-induced carcinogenesis.

Antineoplastic Agents, Phytogenic↗
PubMed1998

Logic and reliability of evaluations of competence to stand trial.

Because the trier of fact determines the weight to be assigned to an examiner's opinion by assessing the strength and persuasiveness of his or her analysis of the data, it is essential that forensic reports communicate the examiner's reasoning process. This study analyzes community examiners' reports on competence to stand trial (CST), emphasizing the nature of examiners' (1) expressed conceptualizations of CST and (2) reasoning establishing a nexus between CST impairments and symptoms of psychopathology. Expert raters coded 100 randomly selected CST reports with respect to a variety of issues, including the examiners' description of the defendant's psycholegal deficits, provision of specific reasoning to link these deficits to psychopathology, and agreement with a paired examiner's global and specific opinions about the defendant's impairments. CST reports were found to (1) reflect basic operationalizations of competence that fail to incorporate legally relevant facets such as a defendant's decisional capacities and (2) adequately document clinical findings, but fail to describe the reasoning underlying psycholegal conclusions. Examiners demonstrated moderately high levels of agreement on defendant's global CST, but expressed radically divergent bases for this opinion. These findings are discussed in light of legal, ethical, and professional standards of practice.

Adult↗
PubMed1996

Synthesis and biological activities of some human gastrin analogs.

The synthesis of analogs of the C-terminal tridecapeptide of gastrin is described. These pseudopeptide analogs were obtained either by replacing the C-terminal phenylalanine amide with 2-phenylethylalcohol or with 2-phenylethylamine, or by replacing the peptide bond between Trp and Leu, or between Leu and Asp with an aminomethylene (CH2NH). The ability of these compounds to stimulate gastric acid secretion in anesthetized rats and to inhibit binding of labeled CCK-8 to isolated cells from rabbit fundic mucosa was tested. [desPhe13, Leu11]-HG-12-I-beta-phenylethylester 33, [desPhe13, Leu11]-HG-12-II-beta-phenylethylester 38, [desPhe13, Leu11]-HG-12-I-beta-phenylethylamide 32, and [desPhe13, Leu11]-HG-12-II-beta-phenylethylamide 37 acted as gastrin receptor antagonists, while [Trp10-psi(CH2NH)-Leu11]-HG-13-I 31 and [Trp10-psi(CH2NH)-Leu11]-HG-13-II 36 acted as agonists. Unexpectedly, [Leu11-psi(CH2NH)-Asp12]-HG-13-I 30 and [Leu11-psi (CH2NH)-Asp12]-HG-13-II 35 were almost devoid of affinity for the gastrin receptor.

Gastric Acid↗
PubMed1989

[Mammographic findings following reduction mammaplasty].

Clinical and mammographic follow-up checks were made on 64 women with a record of breast reduction surgery. Mammographic changes, such as thickened skin, distortion of nipples as well as thickening and dislocation of parenchymal tissue, can be relatively easily differentiated from malignant changes, primarily in cases in which such changes are symmetrical and in which case histories and earlier clinical findings are known. Bilateral calcifications in most cases are caused by calcified fat necrosis.

Adolescent↗
PubMed1988

[Results following reduction mammoplasties. A comparison of selected surgical procedures].

Lactation-retaining reducing mammoplasty was performed on 144 cases for macromastia, with 54 of them being carried out by the Biesenberger/Gelbke method and 90 according to the procedure by Strömbeck. Complications due to wound healing disorders occurred only to eleven in 98 mammae (separate evaluation) treated by the Strömbeck procedure but affected every second patient operated on by the Biesenberger/Gelbke method. In 14 patients postoperative capability of lactation was found to be unambiguously correlated with unimpaired wound healing. Postoperative pathological alterations in mammary glands may cause problems in differential diagnosis. Mitigation of clinico-somatic complaints was found to be obtainable from either surgical approach, depending on wound healing. Aesthetic results are the same.

Adult↗
PubMed1988

[Dupuytren's disease in advanced age. Treatment strategy and results].

The results recorded from 1,322 surgical cases of Dupuytren's contracture of all severities have shown that successful treatment is possible even of patients in advanced age. The concept of surgery and treatment on an outpatient basis was applied to 86.6 per cent of the above cases, with local anaesthesia being used, and has proved to be absolutely adequate, provided high-continuity care by surgeons experienced in hand surgery. Results, prerequisites, and advantages are described in a differentiated manner.

Adolescent↗
PubMed1988

[Cutaneous signs of Noonan's syndrome. Apropos of a case with ulerythema ophyogenes, disseminated pilar and sudoral keratosis and progressive alopecia].

A case of typical Noonan syndrome (NS) with eye abnormalities, pterygium colli, cryptorchid testes, lymphoedema and asymmetrical cardiac septal hypertrophy is reported in a 8-month old infant. This case was particularly interesting since it included skin manifestations which enabled an early diagnosis to be made. Ulerythema ophryogenes has already been proposed as a cutaneous marker of NS, but the keratinization disorders in our patient also included disseminated keratosis of both hair follicles and sweat glands orifices. Abnormally brittle short curly hair has already been reported, but our patient exhibited progressive alopecia which is very rare in NS. Biochemical hair analysis did not show any abnormalities of aminoacids. All these features were suggestive of keratosis follicularis spinulosa decalvans. It therefore seems very likely that NS is associated with keratinization disorders but ulerythema ophryogenes might only be the limited form of these disorders. The other skin manifestations of NS are reviewed. Since the patient had 4 "café au lait" spots, the relation of NS with Von Recklinghausen syndrome, and neurofibromatosis-Noonan syndrome is discussed. Watson's Leopard and cardio-facial syndromes overlap with, and may represent subsets of NS.

Abnormalities, Multiple↗
PubMed1985

Overlapping ionization constants for cefotaxime.

The attribution of three ionization constants (2.1, 3.4, and 10.9) for cefotaxime has been made, based on potentiometric titration and UV absorption data simultaneously. Two overlapping constants were found (2.1 and 3.4) and attributed to the carboxyl group in the 4 position and to the aminothiazole nucleus, respectively.

Cefotaxime↗
PubMed1985

Esterase activities and soman toxicity in developing rat.

The activity of carboxylesterase and cholinesterase in plasma, liver and lung of young rats at different ages (5-31 days old) have been measured. The cholinesterase activity in the tissues of both sexes were almost constant during the development, and were similar to adult male activity. The carboxylesterase activity towards methyl butyrate and 4-nitrophenyl butyrate in plasma of both sexes increased from negligible (5 days old) to adult male value (31 days old). The carboxylesterase activities in liver increased markedly during the period, whereas the lung activities increased only slightly. The toxicity of soman was 6-7 fold higher in 5 days old rats compared to 30 days old rats. The decrease in toxicity correlated well with the increase in plasma carboxylesterase.

Aging↗