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Biomedical subjects

G Bellon

Publications and source records attributed to G Bellon.

151 records · Page 9Linked to original sources
PubMed1978

[Simple methods for the quantification of elastase and its inhibitors in human sera (author's transl)].

Two methods for measuring the elastase activity and the elastase inhibitory capacity of sera or other tissue extracts are described. The elastase inhibitory capacity of 40 human sera is determined using highly purified insoluble elastin in a gelified medium and this value is correlated to the alpha1-antitrypsin concentrations of these sera quantified by radial immunodiffusion. The elastase activity of these sera were determined on high molecular weight soluble kappaelastin peptides immobilized in a gelified medium and we have found a strong dispersion of the individual values. The elastase activity is not correlated either with the inhibitory capacity, the alpha1-antitrypsin or alphai-macroglobulin concentrations of these sera. The sensitivity, specificity and simplicity of these methods render them useful for their application to clinical investigations.

Elastin↗
PubMedDate not supplied

Matrikines in the regulation of extracellular matrix degradation.

The term "matrikines" was coined for designating peptides liberated by partial proteolysis of extracellular matrix macromolecules, which are able to regulate cell activities. Among these peptides, some of them may modulate proliferation, migration, protease production, or apoptosis. In this review, we summarize the activity of matrikines derived from elastin and interstitial or basement membrane collagens on the regulation of matrix metalloproteinases expression and/or activation, and on the plasminogen/plasmin system. Due to their activity, matrikines may play a significant role in physiological or pathological processes such as wound healing or tumor invasion.

Animals↗
PubMedDate not supplied

Modifications of collagens in the course of inflammatory tracheal stenoses.

A comparison was made between the biochemical and histological properties of collagens contained in samples of normal tracheas obtained at autopsy or of stenosed tracheas obtained during surgery. The amounts of total collagen solubilized by pepsin was increased seven times in the pathological samples, and the proportion of cartilage type II collagen decreased by about one half, being replaced by type I collagen, whose ratio was increased five times. Microscopic studies confirmed that cartilage underwent a degenerative process and was progressively infiltrated by fibrils of interstitial collagen.

Adult↗
PubMedDate not supplied

Flow-volume curves in children in health and disease.

Pulmonary function studies were done in 136 children (5.5-17 yr old) of whom 39 had allergic type asthma, 26 chronic bronchorrhea, and 13 mucoviscidosis; the remaining 58 subjects were healthy. The children having respiratory problems were studied when they were clinically free from wheezing and pulmonary infection. Measurements of forced expiration were made with a pneumotachograph; the data were stored on a magnetic tape and analysed with a Hewlett-Packard programmed computer. Standards for the different ventilatory parameters were established for the healthy children. A step by step discriminant linear analysis of the data and application of the Kolmogorov-Smirnov test demonstrated that V25, V50 and MMEF measurements were the best discriminating parameters of pulmonary function abnormalities in the respiratory problem children.

Adolescent↗
PubMedDate not supplied

[Cystic fibrosis in adults].

OBJECTIVES: At least half cystic fibrosis patients now reach adulthood. METHODS: We report a population of 61 patients above 18 years of age with the clinical pictures at time of diagnosis and the present clinical status. RESULTS: Thirty-five males and 26 females are aged from 18 to 47 years. Mean age at time of diagnosis was 5 years and 5 months, under 10 years in 80% of patients and above 15 years in 9 patients. Diagnosis was suspected because of pulmonary (2/3) or digestive (1/3) symptoms, insufficient height and weight (1/3) or past family history of cystic fibrosis (1/3). 37% of patients are homozygotes for delta F508 mutation. Adult patients had a normal height but half of them a body weight under 90% of expected weight. Recurrent pulmonary infections were observed in 95% of patients and 62% have chronically infected sputum with Pseudomonas aeruginosa. These patients had lower weight and a poorer radiological score than patients without pseudomonas. 25% of all patients had chronic respiratory insufficiency. 75% had pancreatic insufficiency and 6 patients diabetes mellitus. Thirteen patients had biological cholestasis and three a liver cirrhosis with portal hypertension. Four women underwent 6 normal pregnancies; semen analysis in five men revealed aspermia. Seven patients died during the last two years because of respiratory insufficiency (4), in the three months after pulmonary transplantation (2), and because of digestive haemorrhage (1). CONCLUSION: Treatment included daily bronchial drainage, adapted antibiotic treatment and pancreatic enzyme substitution.

Adolescent↗