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Biomedical subjects

G Beckman

Publications and source records attributed to G Beckman.

At least 55 records · Page 3Linked to original sources
PubMed1983

Cytogenetic changes in patients with senile dementia.

Chromosome analyses were performed on lymphocytes from patients with Alzheimer type dementia, multi-infarct dementia, Down's syndrome and healthy controls. At least 100 cells were scored from each individual. A significant increase in aneuploidy was observed in the demented patients compared to controls but there was no difference between multi-infarct dementia and senile dementia of Alzheimer type. Nor was there any sex difference in the different groups. Also there was a significantly increased frequency of structurally altered chromosomes among the patients with senile dementia of Alzheimer type compared to other forms of dementia. In the control group such an anomaly was not observed.

Adolescent↗
PubMed1983

Population studies in northern Sweden. XII. The haptoglobin polymorphism.

The haptoglobin groups were studied in a material of 4,333 conscripts and blood donors from the counties of Norrbotten and V asterbotten in northern Sweden. According to their place of birth, the individuals were distributed into 23 subpopulations. In all subpopulations a good consistency with the Hardy-Weinberg equilibrium was found. In contrast to this finding, patients from the same population with immunogenetic disorders (psoriasis, allergy) were found to have a significant deficiency of heterozygotes. The frequency of the Hp1 gene showed significant variations between subpopulations (from 0.24 to 0.45) and the FST in V asterbotten county was high (9.0 x 10(-3)). The variations were, however, not interpretable in terms of ethnic heterogeneity. The results indicate that random processes, most likely 'the four effect', have had a profound effect on the structure of the North-Swedish population.

Ethnicity↗
PubMed1982

Genetic variants of placental alkaline phosphatase as detected by a monoclonal antibody.

Human placental alkaline phosphatase (PLAP) is a highly polymorphic enzyme. Several common as well as rare allelic forms of PLAP are characterized in this paper in terms of their reactivity with a murine monoclonal antibody (F11). The common type 1 (S) and 3 (I) variants, and the rare type 4 (S2) and 18 (D) variants were found to react with the F11 antibody, so as did three new electrophoretically defined variants (19, 20, and 21). In contrast, the common type 2 (F1) variant and the rare type 8 (F3) and 9 (F2) variants do not react with the F11 antibody. This selective reactivity of F11 has also allowed the identification of two molecular variants of PLAP with identical electrophoretic mobility. These results establish monoclonal antibodies as invaluable adjuncts in the study of PLAP polymorphism.

Alkaline Phosphatase↗
PubMed1980

Gc serum groups and schizophrenia.

In an epidemiological study of schizophrenia in a North Swedish isolate, Böök et al. (1978) reported an association between schizophrenia and the genetic marker Gc2. In an attempt to confirm this observation, we examined a series of schizophrenic patients from Västerbotton County in Northern Sweden. In our material there was no difference between schizophrenic patients and controls with respect to the frequencies of Gc groups or genes. A reanalysis of the material by Böök et al. (1978) showed that schizophrenics compared to controls had a significant increase in the frequency of the Gc 2-1 group, but not of the Gc2 gene. The Gc distribution in the material by Böök et al. (1978) was similar to that previously reported by us in a series of patients with cycloid psychosis.

Gene Frequency↗
PubMed1980

Serum levels of alpha-1-antitrypsin in individuals with different Pi M subtypes.

Individuals with heterozygous Pi M subtypes were found to have higher serum levels of alpha 1-antitrypsin (alpha 1-AT) than homozygotes. The alpha 1-AT levels in heterozygotes showed a unimodal distribution. Among homozygotes, a tendency towards a bimodal distribution was found. The mechanism behind this difference is not known. The result can apparently not be explained as the result of a hitherto undiscovered deficiency gene.

Genetic Variation↗
PubMed1980

Alpha 1-antitrypsin phenotypes in Northern Sweden.

By means of isoelectric focusing the alpha 1-antitrypsin phenotypes were examined in 1,869 Swedes from northern Sweden, 300 Finns and 217 Swedish Lapps. The M2 frequency was low among the Lapps and in the northeastern part of Sweden. The frequencies of the S and Z genes were low in the Lapps and in the north-Swedish population. The frequencies of rare phenotypes among Finns from northern Finland were significantly higher than among Finns from southwestern Finland and Aland Islanders.

Finland↗
PubMed1980

Transferrin C subtypes and spontaneous abortion.

The transferrin C subtypes were studied in relation to spontaneous abortion and a number of different genetic markers and traits. Among mothers with a history of spontaneous abortion an increased frequency of the C2 gene and especially of the C2 type was found. A correlation was found between the maternal C2 type and the placental alkaline phosphatase variant F, which previously has been shown to be associated with spontaneous abortion. The mechanism behind the intrauterine selection implied is unlikely to be immunological incompatibility between mother and fetus. No association was found with ABO and Rh blood groups, Hp and Gc serum groups, the pregnancy zone protein (PZ), red cell acid phosphatase types and birth weight.

Abortion, Habitual↗
PubMed1979

Chromosome aberrations in psoriatic patients treated with arsenic.

A significantly increased frequency of chromosomal aberrations was found in lymphocytes from eight psoriatic patients previously treated with arsenic than in lymphocytes from eight psoriatics with no such previous treatment. In most patients the arsenic therapy was discontinued more than 15 years ago. In the arsenic-treated group a statistically significant heterogeneity was found with respect to the frequency of aberrations. The frequency of sister chromatid exchange was not increased in the arsenic-treated patients.

Adult↗