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Biomedical subjects

G Bauer

Publications and source records attributed to G Bauer.

At least 487 records · Page 27Linked to original sources
PubMed1981

[Diagnostic value of periodic lateralized complexes in the EEG (author's transl)].

Periodic lateralized discharges (PLDs) were studied in 68 patients. Seventy nine percent had seizures, mostly of the partial motor type, and 62 percent showed signs of acute seizure activity. In the majority of cases, localizing signs were present at neurological examination or in structural tests. Among the etiological causes, vascular accidents, chronic seizure disorders, space occupying lesions, CNS infections and several other disorders could be identified. None of the EEG characteristics were linked to any clinical variables except the mode of appearance of PLDs. Episodically occuring PLDs correlated to chronic seizure disorders. For pathophysiological explanations, a relationship to the clonic phase of a convulsive seizure was stressed.

Aged↗
PubMed1980

Involuntary motor phenomena in the locked-in syndrome.

Several involuntary movements were observed in patients who were totally immobile except for vertical gaze due to bilateral pyramidal transverse lesion at the pontine or midbrain level. In those conscious locked-in patients extensor spasms and flexor spasms could be elicited by nonspecific stimulation. Mimic pain reactions, pathological crying, and primordial screaming ("cat crying') were also noted. Other motor patterns were whining, moaning, groaning, sighing, and yawning. The pathophysiological implications of these observations are discussed.

Adult↗
PubMed1980

Computerized axial tomography in chronic partial epilepsies.

EEG and CAT studies were performed in 187 adult chronic epileptics. Acute convulsions, known tumor epilepsies, and seizures due to a rapidly advancing neurologic disease were excluded. Partial seizures of elementary and complex symptoms were nearly equally frequent. In 48 patients the etiology of the seizure disorder remained unknown. Among the verified etiologies residual brain damage were the most significant. In 10 cases the chronic seizure disorder was due to slowly growing brain tumors. CAT findings were normal in 86 patients (46%) and abnormal in 101 (54%). Localizing signs could be demonstrated by neuroradiologic and/or radionuclide tests in 15.7%, by CAT in 28.9%, by neurologic examination in 58.3%, and by EEG in 78.1%. Localized CAT-pathology showed no correlation to the types of partial seizures, whereas a significant correlation could be established with residual brain scars and tumors and with localized neurologic or EEG findings. Epilepsy starting after the age of 15 is more likely to be linked with CAT-pathology than with seizure disorders starting in childhood.

Adolescent↗
PubMed1980

Radioimmunological comparison of the DNA polymerases of avian retroviruses.

125I-labeled DNA polymerases of avian myeloblastosis virus and spleen necrosis virus were used in a radioimmunological characterization of avian retrovirus DNA polymerases. It was shown that avian leukosis virus and reticuloendotheliosis virus DNA polymerases do not cross-react in radioimmunoassays. Within the avian leukosis virus species, species-specific and type-specific antigenic determinants of the DNA polymerase were defined. The previous finding of genus-specific antigenic determinants in avian myeloblastosis virus and Amherst pheasant virus DNA polymerases was confirmed and extended to members of all subgroups of avian leukosis virus. It was shown that there is little immunological variation between the DNA polymerases of the four members of the reticuloendotheliosis virus species. Particles with RNA-dependent DNA polymerase activity from the allantoic fluid of normal chicken eggs and from the medium of a goose cell culture did not compete for the antibodies directed against any of the sets of antigenic determinants defined in this study.

Alpharetrovirus↗
PubMed1980

Specific antigenic relationships between the RNA-dependent DNA polymerases of avian reticuloendotheliosis viruses and mammalian type C retroviruses.

Immunoglobulin G directed against the DNA polymerase of Rauscher murine leukemia virus (R-MuLV) could bind to 125I-labeled DNA polymerase of spleen necrosis virus (SNV), a member of the reticuloendotheliosis virus (REV) species. Competition radioimmunoassays showed the specificity of this cross-reaction. The antigenic determinants common to SNV and R-MuLV DNA polymerases were shared completely by the DNA polymerases of Gross MuLV, Moloney MuLV, RD 114 virus, REV-T, and duck infectious anemia virus. Baboon endogenous virus and chicken syncytial virus competed partially for antibodies directed against the common antigenic determinants of SNV and R-MuLV DNA polymerases. DNA polymerases of avian leukosis viruses, pheasant viruses, and mammalian type B and D retroviruses and particles with RNA-dependent DNA polymerase activity from the allantoic fluid of normal chicken eggs and from the medium of a goose cell culture did not compete for the antibodies directed against the common antigenic determinants of SNV and R-MuLV DNA polymerases. We also present data about a factor in normal mammalian immunoglobulin G that specifically inhibits the DNA polymerases of REV and mammalian type C retrovirus DNA polymerases.

AKR murine leukemia virus↗
PubMed1980

Dynamics of Technetium-99m methylenediphosphonate imaging of the femoral head after hip fracture.

A prospective study of the development of necrosis of the femoral head was performed in 34 patients with fractures of the femoral neck. Technetium-99m MDP images of the hip regions were obtained immediately after nailing of the hip and at four, eight and 12 months. There was a good correlation between qualitative and numeric evaluation of isotope uptake in the femoral heads. Comparison of the activity level in the femoral head on the fracture side with that in the contralateral control site showed activity ratios to vary between < 1.0 for those heads showing a general reduction in activity on conventional images to > 1.4 with a mean of 2.0 for those showing increased activity. The initial postoperative images in 2/7 undislocated fractures showed a marked depression in femoral head activity on the fracture side; 13/21 dislocated fractures showed a similar defect suggesting a significant loss of bone remodeling. Normal Tc-99m activity in the femoral head (category 2) was observed in two fracture cases imaged within 24 hours of fracture, just prior to nailing. Repeat studies within one week of fracture and nailing demonstrated a marked depression in activity (category 0). Radiographic evidence of collapse later developed in both patients. The perfusion and blood pool images were useful for identifying femoral heads with deficient circulation. This investigation has demonstrated that the nailing procedure may threaten the vascular condition of the femoral head in hip fracture, that a dead head may be radiographically normal and clinically asymptomatic, and that the metabolic condition of the femoral head may be expressed in numeric terms suitable for statistical analysis.

Adult↗
PubMed1980

[Electroencephalography in epileptic disorders and acute convulsions (author's transl)].

the most important examination of epileptic seizures is the EEG because it is able to reveal interictal changes which indicate pathological processes in neuronal tracts. Diffuse slowing can be seen postical or due to intoxication after both has been excluded in diffuse cortical atrophy. Focal slowing in adults is always suspective of a tumour. -General paroxysmal discharges are frequently characteristical of an epileptic convulsive disorder. Focal spikes do correlate well with the type of seizure. Paroxysmal discharges are primarily indicative of an epileptic disorder-they do, however, occur also without clinical manifestations. Triggering methods (hyperventilation, photo-stimulation, sleep) are a must. The best method, however, to show the typical changes in epilepsy is a long tracing (at least 30 minutes). Acute convulsions are a threat to life. Their etiology are vascular, anoxic, infectious or traumatic changes in the brain. The EEg is in these cases always abnormal.

Electroencephalography↗
PubMed1979

[The effect of metipranolol on the carbohydrate metabolism in diabetics treated with glibenclamide (author's transl)].

Previous investigations on the effect of beta-receptor blockers on the carbohydrate metabolism of diabetics have reported varying effects, the most frequent being hypoglycaemic symptoms which were interpreted as potentiating effects caused by interference with the antidiabetic agents. For this reason, the effect of the beta-receptor blocker metipranolol on the carbohydrate metabolism of diabetics treated with glibenclamide was investigated in a double blind cross-over study comparing metipranolol with placebo. The results do not show any significant difference between the placebo and the metipranolol with respect to the blood or urinary sugar values or the plasma insulin levels. Whether or not this is a substance-specific property needs to be clarified by further comparative investigations using other beta-receptor blockers. There were similarly no significant differences in the most important parameters of hepatic and renal function.

Adult↗