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Biomedical subjects

G Bader

Publications and source records attributed to G Bader.

At least 73 records · Page 4Linked to original sources

[State after pancreatitis--as a clinico-pathological term (author's transl)].

Up to now, little attention has been paid in the clinical as well as in clinico-pathological systematics to the fibrotic "state after pancreatitis" (in its severest form called "cicatrical pancreas"). This state is of interest not only as an increased risk of a recurrent pancreatitis (including acute haemorrhagic pancreatitis), but as well as because of the severe pancreatographic changes, as they occur in (chronic) pancreatitis. In biopsy diagnoses of the pancreas the "cicatrical pancreas" also has to be taken into consideration as a life-long frequently inactive pancreatic disease. With respect to these questions 264 pancreases, among these a series of 144 random autopsy cases, were examined histologically and pancreatographically.

Chronic Disease↗

[Histological changes in the placenta following tokolysis therapy (author's transl)].

In 138 tokolytically treated cases of imminent abortion or premature birth the secundines were examined histologically and compared with 390 cases of pathological gravidities or births without tokolysis therapy. The frequency of occurrence of morphologically manifested circulatory disturbances following tokolysis therapy was equal to that in the untreated cases, the rate of ascendent infections was only slightly increased. In tokolytically treated placentas with the histological pattern of "dissociated disturbed maturation" and "Maturitias retarda" are prevailing. Thus in most cases sufficient supply of the fetus is possible and the critical phase of uteroplacental insufficiency with the danger of abortion or premature birth may be overcome. There were no hints at direct influences of tokolysis on placental morphology.

Abortion, Threatened↗

[Cytological finding in the pre- and early stages of cervix carcinoma--a contribution to the evaluation of Papanicolau III].

Cytologic findings and the histologic diagnosis are compared in 326 cervical cones. We have found following ratio of the groups Papanicolaou (Pap) III: Pap IV--in dysplasia 1: 1: 1, in "more dysplasia than carcinoma in situ (CIS)" 1:2:2. The Pap IV dominates in "pure" CIS and in cones with "more CIS than dysplasia". We take out of the Pap III ("with cytologic control") cases named "Pap III with necessity for histologic diagnosis". We have found in this subgroup of Pap III prestages or early stages of cervical carcinoma.

Carcinoma in Situ↗

[2-year analysis of the results of a screening program on computer basis for the detection of pre- and early stages of cervix carcinoma (model Rostock) (II)].

Two years experiences with a computer-assisted program for early detection of prestages and early cervical cancer in Rostock-city are reported. 65% = 27028 women finally cooperated. Pathological papsmears were found in 0,52%. 9 cases of severe dysplasia, 30 carcinomata in situ, 3 cases of early invasion, 3 micro- and 5 macrocarcinomas were observed. Accessory findings were seen in 10,2%.

Adult↗

[Histological diagnosis in aspiration curettage].

The techniques and diagnostic accuracies for histologic sampling of endometrial tissue after suction curettage performed on 161 patients are discussed. In 90% no tissue was retrieved by sharp curettage after suction curettage. Tissues with higher consistence like polyps were obtained only for 50%. However, it will be expected, that Crumbling tissues of cancer will be obtained.

Curettage↗

Comparative karyometric studies on small pseudolobuli and hepatomas in thioacetamide induced liver cirrhosis.

In the tumorous phase of TAA-induced cirrhosis of the liver comparative studies on the mitotic index, on the frequency of binucleated liver cells and on nuclear volume showed approximately similar values in the small pseudolobuli and in several hepatomas. Obviously "minimum deviation hepatomas" had developed. Decrease of ploidy characteristic for hepatomas was observed. In thioacetamide hepatomas the phenomenon of quadrupling of the cell nuclei due to dysfunctional nuclear edema occurred whereas the normal nuclei of liver cells can only double in volume in all phases of thioacetamide-intoxication. Particular karyometric aspects of the nuclear-nucleolar metabolism of hepatoma cells following thioacetamide intoxication are discussed.

Animals↗

[Clinical pathological studies of the microcarcinoma cervicis uteri (author's transl)].

1. In 232 diagnostical cervix-conisations (almost exclusively on account of positive papsmears) there were 119 carcinomata in situ and 17 microcarcinomata. In accordance and in comparison with other investigators the frequency of microcarcinoma - related to carcinoma in situ - runs up to approximately to 14%. Microcarcinoma was found in 6% of dysplasia and in 10% of all carcinomata in situ. 2. For early clinical diagnosis (for instance papsmears and colposcopy) as well as for therapy the topographical distribution of microcarcinoma is of importance; they have been found almost exclusively on the upper part of the uterine orifice. The treatment of microcarcinoma by means of conisation is being evuluated. An individually differentiated operative therapy is aimed at, by no means, however, the so-called "radical cancer-therapy". 3. Observations concerning cancerogenesis of the carcinoma cervicis are not only of theoretical interest. The "oligophasic" cancerogenesis from dysplasia has been observed - about one fifth of all cases of microcarcinomata came into existence that way. Relatively often a cytotest showed in these cases a Papanicolaou group III. The latter fact should be taken into account in our present time for a differential cytology.

Carcinoma↗

[Methods of localization of chorioamnionitis and their clinical value].

121 out of 390 placentas of mostly pathological deliveries and preganancies were cases of chorioamnionitis. Histological studies have been performed under topographical respects. Several localisations (dynamic phases) of ascending infection of the secundinae are being described and their clinical relevance is being assessed. 1)"Nomal secundinae" or "physiological leucocytosis at ruptured chorionic membranes": there are but a few cases (3 to 5%) of amniotic infection syndroms or morphological signs of an aspiration of infected amniotic fluid and fetal sepsis. 2) "Isolated leucocytosis of the vessels of the umbilical cord and the chorionic plate": it is mostly caused by a fetal hypoxia; relatively seldom it is the result of an infection (about 10%). 3) "Partial phlegmon of the secundinae" (phlegmon of the chorionic membrane with spreading to the periphery of the chorionic plate): about 30% amniotic infection syndrom or infected amniotic fluid (and fetal sepsis respectively. 4) "Subtotal phlegmon of the secundinae" (phlegmon of the chorionic membrane and the chorionic plate in part, spreading to the umbilical cord): about 50% amniotic infection syndrom or infected amniotic fluid (and fetal sepsis) respectively. 5) "Total phlegmon of the secundinae" : in the majority of cases (about 65%) signs of infection damage on mother and/or fetus are visible.

Amnion↗