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Biomedical subjects

G B Fuller

Publications and source records attributed to G B Fuller.

At least 55 records · Page 3Linked to original sources
PubMed1978

Effect of aminoglutethimide phosphate on in vitro oestradiol stimulated progesterone synthesis by rabbit corpora lutea.

Slices of rabbit corpora lutea were incubated for 3 and 8 h with oestradiol-17beta in the presence or absence of aminoglutethimide phosphate (AGP) in order to identify a possible site(s) of action of oestrogen on progesterone synthesis. Oestradiol was unable to increase progesterone biosynthesis above controls in luteal tissue exposed to AGP during either incubation period. AGP alone significantly reduced progesterone concentrations and synthesis from [14C]acetate at both time periods while oestradiol alone increased progesterone mass at 8 h. Changes in 20alpha-OH progesterone typically paralleled those of progesterone at 3 h but no effect of the inhibitor was seen at 8 h. Except for an increase in 14C-incorporation into cholesterol esters in the AGP-treated groups at 3 h the concentration or synthesis of sterols from labelled acetate did not respond to treatment. These results suggested that cholesterol side chain cleavage and cholesterol synthesis are not major in vitro sites of action of oestradiol in the rabbit corpus luteum.

Aminoglutethimide↗
PubMed1977

Comparison of nonpsychiatric blacks and whites on the MMPI.

The literature indicates inconsistent results when MMPI differences between black Ss and white Ss were investigated. In general, most studies found that blacks responded in a more pathological direction. However, previous studies can be criticized because they have used students, prisoners, and hospital patients as Ss with variables that were controlled inconsistently and varied widely. In this study a comparison was made of MMPI scales for 56 black and 56 white males who were full-time employees of a large chemical company. Ss were matched for age, education, occupation, seniority, mental ability level, and socioeconomic level. The 10 standard clinical and 3 validity MMPI scales were recorded for each S as well as six experimental scales: Control (C), Dependency (DPD), Dominance (DOM), Ego Strength (ES), Anxiety Index (AI), and Internalization Ratio (IR). Using K corrected T-scores for the MMPI scales, a repeated measures analysis of variance indicated that subtests and group X subtests were significant. More specifically, blacks scored significantly higher than white Ss on the MA scale, and white Ss scored significantly higher than blacks on the PA, C, DOM, and Es scales. While the present study did find significant differences between black and white Ss on the MMPI, the scores were all well within the normal range (T less than 70), and all scales but two were less than 60.

Black or African American↗
PubMed1976

Differential diagnosis of psychiatric patients with the Minnesota Percepto-Diagnostic Test.

This study investigated whether normals, personality disorders, psychotics and organics could be differentiated by the Minnesota Percepto-Diagnostic Test. There were significant differences between all the groups except the psychotics and personality disorders. It appears that, in general, perceptual disturbance lies along a pathological continuum. Similar performances of psychotics and personality disorders were discussed.

Diagnosis, Differential↗
PubMed1976

Birth sequence in mice.

Succession of deliveries at parturition was determined in mice following a marker injection in utero. The data failed to refute the hypothesis of a random birth order, as delivery from either uterine horn was found to be unpredictable. In addition, significantly more females delivered the first pup from the right uterine horn, supporting the concept of a "physiological dominance" for the right side of the mouse reproductive tract.

Animals↗
PubMed1975

Effect of hormonal environment on sterol concentrations of rat aorta and plasma.

Cholesterol and cholesterol esters were measured on day 90 in the plasma and aortas of rats treated on day 4 as follows: control, gonadectomy, testosterone propionate (TP), estradiol-17beta (E). Sex differences were observed in sterol concentrations of control animals but were abolished by castration. TP and E significantly altered sex gland weights, aorta cholesterol and plasma cholesterol esters of both sexes. Little effect on plasma cholesterol or esterified cholesterol of the aorta was noted in any treatment group. A dose effect of E was observed in organ weights and sterols of male rats.

Animals↗
PubMed1975

Effect of mirex on induced ovulation in immature rats (38550).

PMS-induced ovulation was significantly inhibited in 28-day-old immature rats by acute administration of the chlorinated pesticide Mirex. Numbers of ova recovered were reduced by 40-80% from controls with dose levels of Mirex ranging from 0.4 to 50 mg per animal. When injections of Mirex 48 hr after PMS were followed by HCG the inhibitory effect of the insecticide was overcome, suggesting that the ovary is not the primary site of action. Injections of Mirex at intervals preceding the PMS-induced LH surge resulted in an inhibition of ovulation. Administration of the insecticide after the expected release of LH was ineffective. There was no indication of a premature or delayed release of LH due to injection of Mirex. TPHE DATA SUGGEST THAT Mirex inhibits PMS-induced ovulation by an unknown effect upon neural mechanisms controlling the release of LH.

Animals↗