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Biomedical subjects

G B Edwards

Publications and source records attributed to G B Edwards.

At least 73 records · Page 4Linked to original sources
PubMed1985

Paraphimosis in seven debilitated horses.

This paper reports seven cases of penile paraphimosis which occurred in both entire and castrated horses in association with general debility. Two cases were discharged after treatment while still suffering from partial paralysis; one was discharged at the owner's request with complete paralysis; three were destroyed and one died during treatment. Identified causes of debility were malnutrition, severe parasitism, glucose malabsorption and salmonellosis.

Animals↗
PubMed1985

Tendon injuries in horses treated with carbon fibre implants.

Implants of carbon fibre, made by plaiting a tow of 10,000 filaments of Grafil type HT-S, were used to treat strains and ruptures of digital flexor tendons in 46 horses. The relevant clinical data, the techniques employed and an analysis of the results are described. Apart from two horses in which the implant was extruded and had to be removed, there were minimal untoward consequences of the surgery. Of the 34 horses with acute or chronic tendinitis, 14 returned to racing, seven were used as hunters and seven as hacks. Among the former group, seven suffered a further strain while racing but the others performed well for some time. Twelve horses with severed tendons recovered well and only in one did infection occur. Overall the results in the latter were better than had previously been achieved using other repair materials.

Animals↗
PubMed1984

The regulatory peptide system of the large bowel in equine grass sickness.

In recent years, distinct changes in regulatory peptides have been found in a number of gastrointestinal diseases. Grass sickness is a fatal disease of horses for which the etiology has yet to be fully ascertained. In this study, the peptide-containing nerves and ganglionic and mucosal endocrine cells of the ileum, colon and rectum were investigated in horses with sub-acute or chronic grass sickness and compared with normal controls using immunocytochemistry, at both the light and electron microscopical levels, and radioimmunoassay. A substantial loss of both peptide-containing cells and nerves was found in all of the sick horses, particularly in the ileum. Electron microscopy revealed marked degeneration of nerves in the gut wall. Fibers containing granules immunostained for substance P or VIP, using the immunogold staining technique, underwent extensive degranulation in grass sickness, with the formation of multiple vacuoles. Radioimmunoassay of peptide content also showed that the most drastic changes occurred in the ileum. For example, VIP content was significantly reduced from 109 +/- 19.8 (mean +/- SEM) pmoles/g in controls to 6.8 +/- 1.4 pmoles/g in grass sickness (p less than 0.001) and substance P from 65.9 +/- 8.1 to 31.3 +/- 9.5 (p less than 0.02). These results may have applications in the diagnosis and treatment of grass sickness.

Animals↗
PubMed1984

Equine adenovirus 1 isolated from cauda equina neuritis.

Equine adenovirus 1 was recovered after four to six passages from two out of three cases of cauda equina neuritis (CEN) using kidney monolayers. Similar treatment of lumbo-sacral spinal cord from six normal horses did not yield adenovirus. All three cases of CEN had antibodies to the neuritogenic myelin protein P2 while immunofluorescence demonstrated that autologous IgG bound to the myelin of affected nerves. Adenovirus was not detected in neural tissue by immunofluorescence.

Adenoviridae↗
PubMed1982

Surgical arthrodesis for the treatment of bone spavin in 20 horses.

During a 3 year period 20 horses with bone spavin were treated by surgical arthrodesis of the affected joints. The horses chosen for surgery were those with osteoarthritis, but with little or no evidence of periostitis. Whenever possible they were examined periodically during the postoperative period to evaluate the lameness and to assess the progress of ankylosis by radiography. Three of the horses were still lame 12 months later. The remainder returned to normal work, although one subsequently developed spavin in the other hock and was destroyed. The earliest return to soundness was 3 1/2 months, the longest 10 months (average 5 1/2 months).

Animals↗
PubMed1979

An analysis of 500 cases of equine cryptorchidism.

The authors analyse data collected over 23 years from 500 cryptorchid horses. They show that left- and right-sided abdominal cases occur with approximately equal frequency in ponies. Approximately half the right-sided unilateral abdominal cases have the epididymal tail descended while only 20 per cent of the left-sided cases do. These findings are briefly discussed. From their analysis of inguinal cryptorchidism the authors conclude that it is a relatively more complex phenomenon with incidence changing with age as well as breed. Right-sided retention predominates in young ponies, probably being an extreme expression of testicular hypoplasia, but in older ponies and in other types of horse, retention occurs equally on the left and right.

Abdomen↗
PubMed1978

Infective arthritis of the elbow joint in horses.

Six horses were found to have infective arthritis of one elbow joint. The history, and presence of a small wound on the lateral aspect of the elbow suggested the condition was trauma induced. Two horses recovered following joint lavage under general anaesthesia and antibiotic therapy. The joint changes found post mortem in the others were characteristic of an infective arthritis.

Animals↗