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Biomedical subjects

G Anneroth

Publications and source records attributed to G Anneroth.

At least 37 records · Page 2Linked to original sources

Human pulpal response to direct filling gold restorations.

Class V cavities were prepared in 47 caries-free premolars intended to be extracted for orthodontic reasons. A powdered gold filling material, Goldent, which can be hand condensed, was used for direct fillings. The following test groups were used: (A) cavity preparation, no filling, (B) cavity filled with Goldent only, (C) cavity lined with Tubulitec and filled with Goldent, (D) cavity with Goldent filling, sealed with IRM, and (E) positive and negative controls. The teeth were extracted after 1-200 days and the pulpal response was histologically examined. The results revealed that only in Group B, i.e. when the cavity was filled with Goldent, was the risk of a pulpal reaction obvious, although the material per se (Group D) did not influence the pulpal tissue to any serious degree. Probably the Goldent material cannot provide a marginal seal tight enough to prevent microleakage, allowing microorganisms to give rise to pulp damage and inflammation. In those cases where the cavity had been isolated with Tubulitec liner before the gold restoration was made, the pulp was effectively protected from damage caused by microorganisms.

Adolescent↗

Comprehensive medical examination of a group of patients with alleged adverse effects from dental amalgams.

Mercury from dental amalgams does not seem to cause dose-related intoxications. However, animal studies have shown that high-dose exposure to mercury may support various types of immunologic reactions. Ten patients claiming that their symptoms were caused and aggravated by amalgam therapy were selected for a study of the effects of removal of one amalgam restoration followed by placing of a composite filling. Clinical symptoms and the result of laboratory tests were recorded. Six patients had contact allergies to metals, three of them to mercury ammonium chloride. The comparison of pre- and post-experimental test results showed significant reductions in p-IgE and dU-albumin and significant increases in p-C3d and dU-beta 2-microglobulin. There was no laboratory evidence of a direct toxic effect by mercury on the patients. The observed response by some of the studied factors to the low acute exposure to amalgam may imply that an activation of the immune system occurred.

Adult↗

Gingival fluid and tissues around successful titanium and ceramic implants. A comparative clinical, laboratory, and morphologic study.

The gingival tissue reactions around 19 titanium implants (Brånemark System) and 6 ceramic implants (Frialit) were studied by using established variables for monitoring periodontal status. Natural teeth in the same or the opposite jaw served as controls. Both clinical and laboratory examinations showed healthy gingival status. No differences in soft-tissue reactions between the two types of implant or between the implants and the natural teeth were registered.

Adult↗

Tissue integration of Al2O3-ceramic dental implants: an experimental study in monkeys.

The effect of two different treatment modalities on the tissue integration of Frialit implants was compared in an experimental study in 10 monkeys. The maxillary central incisors were extracted. In one extraction site, chosen by lot, a Frialit implant was immediately inserted, allowing the implant to penetrate the oral mucosa. In the contralateral extraction site, a modified Frialit implant was placed and allowed to heal under a mucoperiosteal flap. None of the implants used in the study was loaded during the observation periods. After experimental periods of 1, 3, 6, and 8 months, the implants were evaluated and monkeys were sacrificed. In situ and histological evaluation showed no significant difference between the two treatment modalities under nonloading conditions. In both cases the healing around the implants was uneventful and good tissue integration was achieved.

Aluminum Oxide↗

Titanium implant anchorage in orthodontic treatment an experimental investigation in monkeys.

Tooth loss can be a problem when orthodontic appliances have to be stabilized for treatment. It has been shown that endosseous titanium implants are well integrated during treatment of edentulous patients with intra-osseous anchored bridges. In the present investigation titanium implants were inserted immediately after tooth extraction. After tissue-integration of the implants they were successfully used for anchorage when orthodontic treatment was performed. In a clinical situation the implants may simultaneously be used for reconstruction of the bite.

Alveolar Process↗

Urinary tract calculi dissolved by means of renacidin. An experimental study.

Removal urinary tract calculi by surgery may be difficult in patients with poor health or in patients who have been operated on earlier. By means of percutaneous nephrostomy it is possible to irrigate the renal pelvis with Renacidin to dissolve calculi. Renacidin is a buffer and mainly consists of citrate and gluconate. The solution makes it possible to dissolve some calculi. This study was carried out in order to evaluate the influence of the concentration of renacidin and of the speed of the irrigation. Urinary tract calculi were obtained from five patients. The calculi were cut into 2 mm thick slices. Each slice was weighed before it was placed in a chamber for irrigation. Irrigation of the slices by means of renacidin was performed at speeds of 30, 60 or 120 ml/h. Slices wre also kept in vessels containing renacidin without replacing the fluid during the irrigation. In two series dissolution was investigated for various concentrations of renacidin. Elementary analysis using absorption and spectrophotometric techniques was performed and a qualitative evaluation of the distribution of the inorganic components was carried out using the microradiographic technique. The speed of the dissolution of urinary calculi varied between 0.43 and 7.7 mg/h. Two stones were easily dissolved (5 and 7.7 mg/h) while the three others were more resistant (0.5, 1.0 and 3.0). Diluted renacidin fluid (1:3) was less effective and reduced dissolution from 5.8 to 0.7 mg/h. The speed of the irrigation was of minor importance in the experimental situation. The dissolving effect of renacidin varied for different calculi.(ABSTRACT TRUNCATED AT 250 WORDS)

Citrates↗

ACP and Surgicel in bone hemostasis. A comparative experimental and histologic study.

The search for a biodegradable material which may prevent or stop bleeding in bone tissue and ensure healing is of continuous interest. ACP, an absorbable collagen paste, is a new hemostatic agent. The present study was devised to compare ACP with another commonly used hemostatic agent, Surgicel, in order to determine the tissue response during bone healing. The materials were implanted in the mandibular bone of New Zealand white rabbits. The observation times were 1, 2, 4 and 8 weeks. The result showed that the healing was uneventful for both the hemostatic agents even though healing was slightly retarded compared to natural healing. Both the hemostatic agents were completely resorbed within 4-8 weeks and also the bone healing was completed after this observation period.

Animals↗

Tissue integration of A12O3-ceramic dental implants (Frialit)--a case report.

The tissue intraosseous integration of A12O3-ceramic dental implants (Frialit) is studied in a patient case, where an implant-fracture made it necessary to remove the implant from a patient's jaw. The surgical removing of the apical part of the implant with the use of a Trepan bur made it possible to examine and visualize histologically and microradiographically the tissue adjacent to the implant. The results of both the histological and microradiographical studies showed that a good healing and osseointegration of the ceramic dental implant (Frialit) was obtained. A direct contact was established between the implant and the surrounding alveolar bone and the induced bone tissue fitted exactly to the contour of the implant. No evidence was found of formation of a connective tissue capsule between the implant and the adjacent alveolar bone nor of any inflammatory reaction in the interface zone. In summary it was evident from the result of the present study that the biocompatibility properties of pure aluminoxide ceramics (A12O3) are excellent and can be recommended as an acceptable alternative among the many different implants, that now are available on the market.

Adult↗

Amelogenesis imperfecta: a scanning electron microscopic and microradiographic study.

The aim of the present study was to use scanning electron microscopy (SEM) to visualize the morphology of the enamel surface in 12 primary teeth from children with amelogenesis imperfecta (AI). The observations were correlated to genetic, clinical and microradiographic data from the same teeth and to non-affected control teeth. SEM showed similar disturbances in teeth with a clinical predominance of hypoplasias and in teeth with a predominance of hypomineralization. In the microradiographs the enamel of most teeth showed both hypoplasias and areas of hypomineralization, independently of the predominant clinical manifestation. In the one boy with an X-linked inheritance pattern, both SEM and microradiography showed the morphology of the enamel to be unique in the present study. In the other teeth, similar manifestations were found in cases with AI as an AD trait and in the sporadic cases.

Amelogenesis Imperfecta↗

Microradiographic study of amelogenesis imperfecta.

A material of 22 primary and 4 permanent teeth from 22 children with amelogenesis imperfecta (AI) were examined by microradiographic techniques. The children were part of a patient material earlier examined in genetical and clinical studies. The results were compared with corresponding data two non-affected control groups and correlated with the available clinical and genetical data. Teeth were examined from seven of the eight different variants of AI seen in the clinical study. In most cases both hypoplasias and areas of hypomineralization were observed in the same tooth, indicating that both the secretory and the maturation phases of the amelogenesis are affected in AI. In teeth from children with the same clinical variant but different inheritance patterns, no specific finding could be related to a specific inheritance pattern. The findings in the one boy with AI as an X-linked trait were unique in this material. In all control teeth except one, no hypoplasisas or areas of hypomineralization were found in the enamel. In conclusion, the subclassification of AI into different forms can be questioned. Variations in clinical and histologic characteristics connected with the same inheritance pattern suggest that the genetic defect, in conjuction with a large biological variation, could explain the multiplicity in clinical expressivity that characterizes AI.

Amelogenesis Imperfecta↗

Current curriculum changes in dental education in Europe.

Recommendations on the knowledge and aptitudes to be acquired during the basic training of dental practitioners have been accepted by the EC member states. WHO conferences in Dublin, 1984 and Moscow, 1988 elaborated further the expected future changes in dental care and dental education in Europe. The dentist's main tasks and the changes in dental education that are needed in order to fulfil these tasks have been defined. As an example, changes in dental education in a European country, Sweden, are described. Problems in Sweden relate to the quality of dental applicants and the necessary changes in the curriculum, including the wider use of comprehensive patient care. In response to this, the 'Malmo model' of dental education has been suggested. The Malmo dental school will presumably be a new type of unit with an integrated education of dentists, dental hygienists, dental assistants and dental technicians. It is intended that this programme will facilitate the better distribution of working tasks between all members of the dental team and will favour the delivery of optimal dental care to the patients.

Curriculum↗

The effect of low-energy infra-red laser radiation on wound healing in rats.

The aim of this study was to evaluate the effect of low-energy infra-red laser treatment on wound healing in rats, both histologically as well as by gross observation. In the caudal area of the back of 14 rats, identical full thickness dermal wounds were punched out bilaterally. One wound in each rat was randomly selected for laser radiation. The contralateral wound was left untreated, serving as a control. All the laser-treated wounds and the untreated control wounds healed in the same way within the same period of time. No difference was observed concerning bleeding time, nor as to the formation and loss of crust. None of the wounds showed signs of infection during the observation period. Histological examination indicated no obvious morphological difference between the laser-treated and the untreated wounds. The present study did not confirm that the use of low-energy infra-red laser radiation could improve the wound healing process.

Animals↗

Re- and allotransplantation of teeth--an experimental study in monkeys.

In each of six monkeys one of the permanent lateral incisors with uncompleted root development was replanted. At the same time the contralateral incisors in four of the monkeys were allotransplanted by pairs. The remaining two contralateral incisors served as controls. After 4 weeks and 4 months, respectively, three monkeys were decapitated and the upper lateral incisors with adjacent periodontal tissue were examined histologically. The replanted teeth in five cases had a vital pulp. In the sixth case, however, the replanted incisor exhibited pulpitis and partial necrosis of the pulp. The periodontal membrane had a normal histologic appearance. In two cases a small area of arrested root resorption was observed. With the allotransplanted teeth the histologic appearance was altered. After 4 weeks a pronounced inflammatory reaction was observed in both the pulpal tissue and the periodontal membrane. The pulp was in most cases necrotic, and marked root resorption was observed. Most of the allotransplanted teeth were resorbed and replaced by an irregular hard tissue that resembled osteoid, which in many cases was connected with the tooth remnants by ankylosis. These results indicate that allotransplanted teeth, in contrast to replanted teeth, exhibit the characteristic features of an allograft rejection, including an inflammatory reaction and resorption.

Animals↗

Macroscopic and radiographic examination of proximal root surface caries.

The purpose of the study was to compare macroscopic and radiographic examination of proximal root surface caries of extracted teeth from patients aged 65-95 years. Although the study conditions for macroscopic and radiographic diagnosis favored more sensitive evaluations than routine clinical conditions, there was a 24% disagreement in diagnosis. This finding indicates that under routine clinical conditions it is difficult to register with certainty all superficial root carious lesions. Even in the absence of clinically detectable root surface caries, preventive measures should be considered for elderly people with exposed root surfaces.

Aged↗

Absele in bone hemostasis--a clinical and experimental investigation.

Control of bleeding from bone tissue may sometimes be difficult to maintain. Existing methods of haemorrhage control with standard bone wax can interfere with subsequent healing. This paper presents clinical and experimental results of the use of a new absorbable bone sealant, Absele a paste made from stabilised fibrin and soluble collagen.

Adolescent↗