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Biomedical subjects

G Angelini

Publications and source records attributed to G Angelini.

At least 145 records · Page 8Linked to original sources
PubMed1983

Comparative evaluation of different methods for calculation of cerebral blood flow (CBF) in nonanesthetized rabbits.

The measurement of cerebral blood flow (CBF) by the extracranial detection of the radioactivity of 133Xe injected into an internal carotid artery has proved to be of considerable value for the investigation of cerebral circulation in conscious rabbits. Methods are described for calculating CBF from the curves of clearance of 133Xe, and include exponential analysis (two-component model), initial slope, and stochastic method. The different methods of curve analysis were compared in order to evaluate the fitness with the theoretical model. The initial slope and stochastic methods, compared with the biexponential model, underestimate the CBF by 35% and 46% respectively. Furthermore, the validity of recording the clearance curve for 10 min was tested by comparing these CBF values with those obtained from the whole curve. CBF values calculated with the shortened procedure are overestimated by 17%. A correlation exists between the "10 min" CBF values and the CBF calculated from the whole curve; in spite of that, the values are not accurate for limited animal populations or for single animals. The extent of the two main compartments into which the CBF is divided was also measured. There is no correlation between CBF values and the extent of the relative compartment. This fact suggests that these two parameters correspond to different biological entities.

Anesthesia↗
PubMed1983

Reliability of the Bz-Ty-PABA and the pancreolauryl test in the assessment of exocrine pancreatic function.

The reliability of the para-aminobenzoic acid (PABA) test (performed in the conventional manner, i.e. without control day) and of the pancreolauryl test was assayed in respect of the exocrine pancreatic capacity measured by using the secretin-caerulein test in 57 subjects, 22 of which were suffering from chronic pancreatitis. When 50 and 20% urinary excretion of the orally administered Bz-Ty-PABA and pancreolauryl, respectively, were chosen as the lower normal limits, the PABA test showed a specificity quite similar to that of the pancreolauryl test (97 and 95%, respectively) despite the lack of a control day test, but a lower sensitivity (39 vs. 83%). The association of both tests was not advantageous compared with the pancreolauryl test alone.

4-Aminobenzoic Acid↗
PubMed1983

T cell subsets and soluble immune response suppressor (SIRS) factor in skin squamous cell carcinoma.

T cell subsets (theophylline-sensitive T lymphocytes and T gamma lymphocytes), and the activity of soluble immune response suppressor (SIRS) factor have been investigated in a total of 53 patients with squamous cell carcinoma (SCC) of the skin. Eight of these had metastatic regional lymph nodes. The results showed decreased values for theophylline-sensitive T lymphocytes and elevated values for T gamma cells. Suppressor function evaluated by means of SIRS factor was normal in 36 patients with non-metastatic skin SCC and decreased in 8 with metastatic skin cancer.

Adult↗
PubMed1983

Monocyte Fc-IgG receptors expression and soluble suppressor factor in skin squamous cell carcinoma.

The expression of Fc-IgG receptors on mononuclear phagocytes (monocytes/macrophages), as well as the activity of soluble immune suppressor supernatant of T-cell proliferation (SISS-T) factor have been investigated in 23 patients with squamous cell carcinoma (SCC) of the lower lip, including 8 patients with metastases in the regional lymph glands. The results demonstrated a significant increase of the expression of Fc-IgG receptors only on circulating monocytes of patients with metastatic SCC. The suppressor function evaluated by means of the SISS-T factor proved normal in patients with nonmetastatic skin SCC and reduced in 8 patients with metastatic SCC.

Adult↗
PubMed1983

Serum primary bile acids in chronic alcoholic pancreatitis.

Since cholestasis is a common, although poorly recognized, complication of chronic pancreatitis, and bile acids seem to be a sensitive index of cholestasis, fasting and post-prandial s-cholic and s-chenodeoxycholic acids were determined by radioimmunoassay in 48 chronic alcoholic pancreatitis patients (CP) and 22 healthy controls (C). Patients were grouped as follows: chronic pancreatitis with and without cholestasis; chronic pancreatitis operated on or not. A statistically significant increase in both CA and CDCA was observed in CP with cholestasis vis-a-vis C. In the CP without cholestasis and with normal biliary tract the average CA and CDCA values were also higher than in C, even though the difference was not statistically significant. No difference was observed between patients submitted or not submitted to pancreojejunostomy. The CA/CDCA ratio was increased in all CP subgroups, even in the patients without cholestasis, with significant difference only for some samples. Thus an increase in serum bile acids can be detected.

Alcoholism↗
PubMed1982

T gamma and theophylline-sensitive T lymphocytes in allergic contact dermatitis.

Two lymphocyte subpopulations, T cells bearing a receptor for the Fc fragment of IgG (T gamma) and theophylline-sensitive T cells, were investigated in 49 patients with allergic contact dermatitis (ACD) in the acute phase and compared with a control group. Patients with ACD had markedly reduced relative T gamma and theophylline-sensitive T lymphocyte levels, compared with normals (P less than 0.0005). The patients also showed reduced absolute T gamma and theophylline-sensitive T cells with respect to the controls (P less than 0.01). To determine whether decreased levels of T gamma and theophylline-sensitive T cells were related to the activity of ACD, the same T-cell subsets were determined in 10 of 49 patients after the clearing of the contact dermatitis. Both T-cell subpopulations were found within the normal range.

Adolescent↗
PubMed1982

Pancreatic exocrine function in rosacea.

As some rosacea patients complain of gastrointestinal troubles and the administration of pancreatic extracts ameliorates both dyspepsia and skin lesions, the pancreatic exocrine function in 21 subjects affected with rosacea has been investigated by means of the secretin-cerulein infusion test. 21 healthy controls have been studied for comparison. No difference was found between rosacea and control subjects for flow rate, bicarbonate and chymotrypsin concentration and output, while lipase concentration and output was significantly lower in rosacea patients, with a decrease ranging from 18.5 to 66% of normal values. Therefore, a deficient lipase secretion could be responsible, at least partly, for the clinical manifestations of rosacea.

Adult↗
PubMed1981

[Somatopsychologic correlations in gynecologic surgery].

Surgical interventions generally generate irrational fantasies and hidden anxieties concerning the body image, the sexual identity and the Ego identity. Some defense mechanisms are then utilized, tending to preserve the physical and psychic integrity, particularly when, as in gynaecological surgery, the interested organs are charged with important symbolic significance. The social, psychological and cultural aspects of gynaecological surgery necessarily involved three subjects: the patient her family, and the physician; each of them plays an important role for the success of every surgical operation. The post-intervention clinical pattern of the psycho-somatic and somato-psychic symptoms is structurally linked to the patient relationship with her partner (or her family) and with her physician. The physician should enable his patient to exactly comprehend the situation and to distinguish between the real fears for intervention and the irrational ones, bound to fantasmatic projections concerning her body image. After a review of the existing literature three clinical histories are briefly reported, which confirm the importance of a biological support during the delicate phase of the surgical intervention and the recovery.

Adult↗