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Biomedical subjects

G Anderson

Publications and source records attributed to G Anderson.

At least 325 records · Page 18Linked to original sources
PubMed1983

Linen management.

Explore the source record for details and available documents.

Bedding and Linens↗
PubMed1983

Anticholinergic drugs in airways obstruction.

This paper reviews briefly the place of ipratropium bromide in the treatment of airways obstruction. Oxitropium bromide, a new quaternary ammonium compound derived from scopolamine was shown to be as effective a bronchodilator in a dose of 200 micrograms by inhalation as ipratropium bromide 80 micrograms in 20 patients with atopic asthma.

Asthma↗
PubMed1983

Prophylactic drugs in asthma.

The search for a successor to disodium cromoglycate has been unsuccessful. The published studies concerning the use of ketotifen in asthma are reviewed. It is concluded that ketotifen is of doubtful benefit although it may have a weak prophylactic effect.

Asthma↗
PubMed1983

The use of antibiotics in acute-on-chronic bronchitis.

Acute exacerbations of bronchitis are probably best treated with erythromycin or cotrimoxazole. The rising incidence of ampicillin resistance is reducing its value. Oxytetracycline and cephalosporins are best avoided. Trimethroprim may prove a safer alternative to cotrimoxazole. However, all these conclusions are based on theoretical reasons rather than large comparative trials.

Anti-Bacterial Agents↗
PubMed1982

A prospective multi-institutional study of antepartum fetal heart rate monitoring. II. Contraction stress test versus nonstress test for primary surveillance.

This study includes, 1,542 patients who underwent nonstress tests (NSTs) for primary fetal surveillance and 4,626 patients who underwent contraction stress tests (CSTs) for primary fetal surveillance. All pregnancies were at increased risk for uteroplacental insufficiency. The results showed that the two groups were comparable according to maternal diagnostic criteria for testing. Those patients who underwent NSTs as primary surveillance had a 2.9% incidence of intervention because of abnormal test results while the CST group had a 4.5% incidence of intervention because of abnormal test results ( p less than 0.05). The NST group had significantly more respiratory distress syndrome, intrauterine growth retardation, birth weight less than 2,500 gm, and 5-minute Apgar scores less than 7. The antenatal death rate was nearly eight times higher in the NST group (7.8/1,000 versus 1.1/1,000 in the CST group) (p less than 0.05). After correction for congenital anomalies and unrelated causes, the NST group had an antenatal death rate of 3.2/1,000 versus 0.4/1,000 in the CST group (p less than 0.05); there was still an antenatal death ratio of 8:1.

Apgar Score↗
PubMed1982

Conditioned tolerance to the tachycardia effect of ethanol in humans.

Human subjects were given a series of oral ethanol administrations in one environment and an equal number of placebo administrations in another distinct environment. Tolerance (a decreasing response with repeated administrations) to the tachycardia effect of ethanol was observed; no consistent changes in heart rate followed placebo administrations. Subsequently, tolerance to a test dose of ethanol administered in the environment normally associated with placebo was reduced relative to that in response to a dose administered in the usual ethanol environment. This demonstration of environment-specificity in a human drug tolerance experiment replicates previous reports from animal studies, and is interpreted according to a Pavlovian conditioning model of drug tolerance.

Adult↗
PubMed1982

A double-blind clinical trial of ketotifen and disodium cromoglycate in bronchial asthma.

A double-blind cross-over trial compared the efficacy of ketotifen (1 mg b.d.) and DSCG (20 mg q.d.s.) as prophylactic therapy for asthma. It involved two eight-week periods of active therapy, each being preceded by two weeks of double placebo treatment. Analysis of symptoms recorded on diary cards showed that there was a reduction in the cough score in the atopic asthmatics on DSCG compared to ketotifen, and reductions in the cough score, wheeze and dyspnoea on DSCG when compared with placebo. There was a significant reduction in the diurnal variation in PEFR during treatment with DSCG compared to ketotifen and improvement in morning PEFR on DSCG compared with placebo. It was concluded that DSCG resulted in a significant therapeutic effect during the trial, whereas ketotifen (1 mg b.d.) did not.

Adult↗
PubMed1982

Sustained-release theophylline in chronic bronchitis.

Twenty-one patients with chronic bronchitis entered a double-blind, cross-over study in which they received sustained-release theophylline ('Nuelin'SA) 350 mg daily for 4 days followed by 700 mg daily for 4 days and matching placebo tablets for 8 days with one week separation. Seventeen patients completed the study. Three patients receiving higher doses for weight than the mean for the group were withdrawn because of side-effects. Mild side-effects only were reported in six other patients. Theophylline given twice daily produced a steady-state mean serum concentration of 13.9 micrograms/ml, 13 patients having concentrations inthe range of 10-20 micrograms/ml. There was no demonstrable improvement of symptoms but pulmonary function measurements in the clinic at the end of active treatment showed a statistically significant improvement in PEFR, 1-second forced expiratory volume and forced vital capacity.

Adult↗
PubMed1982

A controlled study of slow-release theophylline and aminophylline in patients with chronic bronchitis.

Twenty patients with chronic bronchitis who were also receiving beta-agonist inhalers entered a single-blind cross-over study comparing slow-release aminophylline (Phyllocontin) 325 mg twice daily and slow-release theophylline (Rona-slophyllin) 250 mg twice daily with placebo. 16 subjects who completed the study showed no objective or subjective benefit with either active preparation. Eight of the 16 patients achieved plasma theophylline levels of greater than 10 micrograms/ml on each of the drugs but no benefit was found when this group was analysed separately.

Aged↗