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Biomedical subjects

G A Balint

Publications and source records attributed to G A Balint.

At least 55 records · Page 3Linked to original sources
PubMed1986

Data to the intracellular effects of prostacyclin in rat gastric mucosa.

Using specific radioimmunoassay it seems that Prostacyclin has a strong effect on the cyclic nucleotide-content of the rat gastric antral mucosa. Shortly (1 min) after an intragastric application of 100 micrograms/kg Prostacyclin the cAMP and the cGMP-content showed a significant decrease. Investigating the antral and fundic mucosal calmodulin-levels, it seems that 15-30 mins after Prostacyclin application both tend to increase. It seems very probable that the primary intracellular effect of Prostacyclin in the gastric mucosa is directed to the so-called 'second messenger system' but later Prostacyclin activates the calmodulin-system too.

Animals↗
PubMed1986

Changes of endogenous prostacyclin-level in different experimental gastroduodenal ulcer models of rat.

It seems that the gastric antral mucosa either in normal, physiological circumstances, or in IND or STR induced gastric ulcer models, contains significantly more endogenous PG-I2 than that of gastric fundic mucosa, while the duodenal mucosa contains significantly lower endogenous PG-I2-level compared to the gastric antral or fundic level. Either in gastric or in duodenal ulceration the endogenous PG-I2 level basically decreased proportionally to the degree of ulceration - therefore it is tempting to speculate that the endogenous PG-I2 is most probably one of the natural protective substances in the gastrointestinal mucosa.

6-Ketoprostaglandin F1 alpha↗
PubMed1986

The effect of cigarette smoke on gastroduodenal mucosal endogenous prostacyclin level (experimental and clinical observations).

In our opinion the endogenous prostacyclin (PGI2) is one of the most important natural protective substances in the gastric mucosa. We have, therefore checked in experimental circumstances in rats, as well as in clinical observations in humans, the possible effect of smoking on endogenous gastroduodenal mucosal PGI2 level. The animal experiments seem to verify that cigarette smoke really has an unwanted effect on the gastric mucosa. The target of this action is the endogenous PGI2 content of the mucosa. According to our observations in humans there is a definite tendency toward decreased endogenous PGI2 production in the gastroduodenal mucosa of smokers too.

6-Ketoprostaglandin F1 alpha↗
PubMed1985

Prostacyclin acts in rat gastric (fundic) mucosa via the intracellular 'second messenger system'.

Using a specific radioimmunoassay technique it seems that Prostacyclin (PG-I2) has a strong effect on the cyclic nucleotide content of the rat gastric (fundic) mucosa. 1 min after an intragastric application of 100 micrograms/kg PG-I2 the cAMP-content and in the 5th min the cGMP-content showed a highly significant decrease. It seems that the basic mechanism of action of PG-I2 is a typical 'hit and run' effect, acting on the intracellular 'second messenger system'.

Animals↗
PubMed1985

Gastric antral and fundic mucosal protein, DNA and RNA changes in different experimental ulcer models.

The changes in gastric (fundic and antral) mucosal protein, DNA and RNA content, have been investigated in different experimental gastric ulcer models of rat. It seems that indomethacin and stress (restraint) ulcer formation were followed by a predominant fundic (oxyntic cell area) mucosal DNA increase, while in the antral mucosa this phenomenon was connected to a significant RNA increase. The observed changes of the RNA/DNA ratio in the fundic mucosa were interpreted as a sign of accelerated cell renewal. The authors conclude that during ulceration the regenerative processes concomitantly take place.

Animals↗
PubMed1985

The effect of long-term prostacyclin treatment on the protein, DNA and RNA content of rat gastric fundic mucosa.

The changes of gastric fundic mucosal protein, DNA and RNA content have been investigated during long-term (40 and 80 days respectively), prostacyclin treatment. It seems that a longer prostacyclin treatment induces a significant thickening of the gastric fundic mucosa. This phenomenon might be explained by the hyperplasia of matured cells. This assumption is strengthened by the results obtained checking the DNA and RNA-levels of the mucosa.

Animals↗
PubMed1984

Gastrointestinal mucosal gamma-glutamyl transpeptidase activity changes in different ulcer models of rat.

The experiments presented gave evidence that changes in gamma-glutamyl transpeptidase activity-under experimental circumstances-seem to be in close connection with gastro-intestinal ulceration. In the pre-ulcerative period in both gastric and duodenal ulcer models, the mucosal gamma-glutamyl transpeptidase activity is higher than normal, while in the definitive ulcerative stage the gastric gamma-glutamyl transpeptidase activity is significantly decreased but in the duodenum it remained on normal level. This phenomenon may reflect to a difference in the pathomechanism of the gastric and duodenal ulceration.

Animals↗
PubMed1983

Different protective effects of dimercapto-butanediol stereoisomers in experimental gastric ulceration.

The erythro version of 1, 4,-dimercapto-2, 3,-butanediol provided a significant protection against experimental gastric ulcer induced by indomethacin, while it was ineffective in stress ulcer of rats. The threo version of the same compound showed a complete ineffectiveness. It seems that most probably there is a specific receptor system in the living organism where only the erythro version is effective. Moreover, there was a remarkable difference between indomethacin-induced and stress ulcer as far as their protection is concerned. Sulfhydryl containing substances inhibited indomethacin ulcer but they were ineffective against stress ulcer. This experimental result provides further data for the difference of the pathomechanism of various experimental ulcers and thus their direct extrapolation to the human disease and to its treatment needs extreme caution.

Animals↗
PubMed1980

Laboratory method for measuring small amounts of tissue glycogen.

A procedure is reported which is well applicable for the quantitative determination of glycogen, especially in cases of a small glycogen content in a small amount of tissue. The method consists of extraction of glycogen by boiling potassium hydroxide, precipitation with ethanol, hydrolysis with sulphuric acid, and determination of the glycogen in form of glucose obtained with orthotoluidine.

Animals↗
PubMed1979

Effects of prostaglandin E2 and F2 alpha on the absorption and portal transport of sugar and on the local intestinal circulation.

With the isolated jejunum loop technique investigations of prostaglandin E2 and F2 alpha were made on canine intestinal absorption and transport of glucose and on the circulation of the intestinal loop. These compounds decreased glucose absorption; intra-arterial prostaglandin administration decreased the portal transport of glucose, but intraluminal administration caused an increase. PGE2 enhanced the circulation of the intestinal loop; intra-arterial PGF2 alpha diminished this circulation, whereas on intraluminal PGF2 alpha had no significant effect.

Animals↗
PubMed1976

On the mechanism of pyrogenic action of ricin.

The incubation of rabbit white blood cells with ricin, the toxic protein of castor oil seeds, leads to the production of endogenous pyrogens. This induction can be inhibited by the antibiotics actinomycin D or cycloheximide. The results are discussed in terms of disturbed corticosteroid- and Mg2+-levels.

Animals↗