Biomedical subjects

Fan Jin

Publications and source records attributed to Fan Jin.

75 records · Page 5Linked to original sources

PubMed2002

Urinary excretion of phytoestrogens and risk of breast cancer among Chinese women in Shanghai.

Although the majority of ecological and experimental studies have suggested a potential role of phytoestrogens in breast cancer prevention, findings from epidemiological studies have been inconsistent. Part of the inconsistencies may be attributable to the difficulty in measuring intake levels of phytoestrogens. Overnight urine samples from 250 incident breast cancer cases and their individually matched controls were analyzed for urinary excretion rates of isoflavonoids, mammalian lignans, and citrus flavonoids. The study subjects were a subset of the participants in the Shanghai Breast Cancer Study, a large population-based case-control study conducted in Shanghai from 1996-1998. To minimize potential influence of treatment on the exposure of interest, urine samples from breast cancer cases were collected before cancer therapy. Urinary excretion of total isoflavonoids and mammalian lignans was substantially lower in breast cancer cases than in controls. The median excretion rate of total isoflavonoids was 13.97 nmol/mg creatinine in cases and 23.09 in controls (P = 0.01), and the median excretion rate of total lignans was 1.77 in cases and 4.16 in controls (P < 0.01). The risk of breast cancer was reduced with increasing excretion of total isoflavonoids (P for trend, 0.04) and total lignans (P for trend, <0.01), with adjusted odds ratios of 0.62 (95% confidence interval, 0.39-0.99) and 0.40 (95% confidence interval, 0.24-0.64) observed for the highest versus the lowest tertile of total isoflavonoid and lignan excretion, respectively. The adjusted odds ratio was 0.28 (95% confidence interval, 0.15-0.50) for women who had a high excretion rate of both total lignans and isoflavonoids compared with those with a low excretion of both groups of phytoestrogens. No association was observed with citrus flavonoids. The results from this study suggest that high intake of certain phytoestrogens may reduce the risk of breast cancer.

Adult↗

PubMed2002

[Obesity at different ages and endometrial cancer risk factors in urban Shanghai, China].

OBJECTIVE: To study the relationship between obesity at different ages and the risk of endometrial cancer in urban Shanghai, China. METHODS: In a population-based case-control study conducted in urban Shanghai, in-person interviews and anthropometric measurements were completed for 497 women at age 30 to 69 and an equal number of controls frequency-matched to cases on age distribution. All cases were newly diagnosed with endometrial cancer from January 1, 1997 to June 30, 2000. Unconditional logistic regression model was employed to estimate the adjusted odds ratios (ORs) and 95% confidence intervals (CIs) of the obesity at different ages. RESULTS: After adjustment for some potential confounding variables, neither adolescent height nor weight was significantly related to endometrial cancer. Obesity in adulthood, except around 20 years old, was associated with elevated risks, with odds ratios for the highest versus lowest quartile of body mass index (BMI) being 1.5 (95% CI: 1.0 - 2.1), 1.7 (95% CI: 1.2 - 2.4), 1.9 (95% CI: 1.3 - 2.8) and 1.7 (95% CI: 1.0 - 2.7) at ages 30, 40, 50 and 60, respectively. Weight gain of more than 7.5 kg at different 10-year intervals in adulthood were associated with increased risk of endometrial cancer, whereas only weight gain more than 15% of initial weight from 40 to 50 years old significantly related to the risk. Only weight loss from ages 20 to 30 was inversely associated with endometrial cancer risk (OR = 0.4, 95% CI: 0.2 - 0.8). Current body weight, BMI and waist-to-hip ratio (WHR) were independent risk factors to endometrial cancer while standing height and sitting-to-standing height ratio were unrelated to the risk of endometrial cancer. CONCLUSION: Results indicated that adolescent obesity was unrelated to endometrial cancer. General obesity in adulthood, as well as body fat distribution, were associated with the risk of endometrial cancer independently. Weight changes before and after age 30 had different effects on the risk of endometrial cancer.

Adult↗

PubMed2002

Rapid increase in colorectal cancer rates in urban Shanghai, 1972-97, in relation to dietary changes.

BACKGROUND: In urban Shanghai, the largest industrial and commercial city in China, the age-adjusted (to world standard) incidence rates for colorectal cancer increased from 14.8 to 24.1 per 10(5) man-years and from 11.7 to 20.7 per 10(5) woman-years between 1972-73 and 1996-97. These changes were even more pronounced for colon cancer. The reasons for the rapid increases in cancer rates are not fully understood, but may involve dietary habits that have changed substantially overthe past two decades. METHODS: Based on incidence data on 37000 colorectal cancers from 1972-1997 and dietary information during the past 20 years, an ecologic correlation analysis was performed. RESULTS: Available data indicate that per capita food consumption in Shanghai of vegetable oil, poultry, eggs, and pork rose rapidly during the period 1978-97, whereas consumption of seafood, grain, and fresh vegetables changed little or showed little consistent trends. Statistically significant positive associations were observed between colon cancer rates and per capita consumption of vegetable oil, poultry, fresh eggs and pork. DISCUSSION: These findings suggest that increases in dietary fat and certain protein consumption may play a role in the rising colon cancer rates in Shanghai.

China↗