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Biomedical subjects

F Wohlrab

Publications and source records attributed to F Wohlrab.

At least 73 records · Page 4Linked to original sources
PubMed1976

[Initial changes in the vascular metabolism and their relations to atherogenesis].

In a survey initial changes of the metabolism of the vascular wall under the influence of atherogenic noxae in the animal experiment are described. Already a short time after the effect of atherogenic noxae (so-called proliferative phase) the activities of respiratory mitochondrial enzymes in the cells of the smooth muscles of the tunica media of the aorta are considerably reduced in different species. It is a clue to the fact that a hypoxically induced defect in the arterial wall is to be taken into considerations as a pathogenetic factor for arteriosclerosis. Up to now there are no exact proofs for the fact that a transition to a high rate of glycolysis would be predisposing for the appearance of arteriosclerotic changes. The influence of a hypoxia on the vascular wall is not only restricted to the cellular energy metabolism, but stimulates also other cellfunctions. Under hypoxic conditions the synthesis of fatty acids in the arterial tissue is increased. Several authors are of the opinion that a continuous increased supply of lipids overchanges the processes of the cellular regulation which are responsible for the metabolisation of the lipids. The transition into the proliferative phase is characterized by increased insertion rates or transformation rates for different substances in the activated myointimal cells which focally or generally leads to a proliferation or migration into the intima. The proliferating cells distinguish themselves by high activities of different oxidative enzymes which is to be regarded as a reference to an increased readiness of connections rich in energy, according to the high synthetic capacity of these multifunctional mesenchymal cells.

Animals↗
PubMed1976

[The distribution of isoenzymes of lactate dehydrogenase in benign and malignant neoplasms of the human prostate (author's transl)].

The distribution of LDH isoenzymes from homogenate supernatant of bioptically obtained benign and malignant tumours of the human prostate was investigated by agar gel electrophoresis and correlated with the degree of histological differentiation of these tumours. In comparison to the benign adenomas (52.6% H subunits), the values of H subunits declined (adenocarcinomas 47.3% H subunits) in dedifferentiated carcinomas to 37.1% on the average which demonstrate a tendency of increased malignancy. The LDH isoenzyme distribution of malignant tumours is correlated with the degree of histological differentiation of these tumours, which is important for the clinical prognosis.

Adenocarcinoma↗
PubMed1975

[The influence of experimental diabetes on the distribution of LDH-isoenzymes in rat skeletal muscle (author's transl)].

The distribution of LDH-isoenzymes from homogenate-supernatant of M. soleus of normal and streptozotocin-diabetic male rats was investigated by agargel-electrophoresis. Five LDH-isoenzymes could be detected in the M. soleus of normal rats; the average proportion of H-subunits was 69.1% (age 3-4 month) resp. 69.6% (age 13 month) from the total value. In male rats of the same age a mild diabetes was induced by intravenous injection of 65 mg streptozotocin per kg body weight. In the M. soleus of these animals also 5 LDH-isoenzymes were detected. After 1-2 month duration of diabetes the LDH1 is decreased from 30.3% of controls to 18.2% and the LDH4 is increased from 11.1% of controls to 20.1%. The H-subunit value decreased to 61.9% from the total value. In long term diabetes (11 month) the values of single fractions and the H-subunit value did not differ from those of controls. The findings are discussed considering the composition of M. soleus on different fiber types and the influence of diabetic conditions.

Animals↗