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Biomedical subjects

F Weber

Publications and source records attributed to F Weber.

At least 271 records · Page 15Linked to original sources
PubMed1981

Surgical treatment for congenital occlusion of the inferior vena cava in its diaphragmatic portion.

This is a case report on a congenital occlusion of the inferior vena cava in its diaphragmatic part. Additionally, the proximal 10 cm within the retrohepatic portion of the vessel were highly stenotic. With exception of the vena hepatica brevis all larger hepatic veins were occluded. Correction was achieved using a 14 mm Gore-Tex (Polytetrafluoroethylene) graft, which connected the abdominal part of the inferior vena cava to the right atrium.

Adult↗
PubMed1981

[Comparative clinical study on the accuracy of conventional and electronic blood pressure self-measuring devices (author's transl)].

19 conventional and 19 electronic blood pressure measuring devices were tested on a average of 23 patients each. The patients were classified according to age, sex, and experience in blood pressure measurement. Altogether, the accuracy of the electronic devices was inferior to that of the conventional apparatus. Especially the diastolic blood pressures were estimated considerably too low by the electronic devices. Furthermore, these instruments were more sensitive to a false position of the microphone membrane than the conventional devices and they showed, in the average, greater differences between two exemplars of the same instrument. Blood pressure readings with conventional devices were significantly influenced by the patients' experience (systolic blood pressure) and age (diastolic blood pressure), whereas the readings with electronic machines were significantly affected by the patients' sex (systolic and diastolic blood pressure) and age (diastolic blood pressure). The result of the technical development of blood pressure devices for self-measurement is rather disappointing, especially with respect to costs and benefits.

Adolescent↗
PubMed1979

[Antimicrobial resistance and serotypes of Streptococcus pneumoniae in Switzerland].

One hundred and eighty strains of Streptococcus pneumoniae were isolated from various materials at the Institute of Medical Microbiology in Zurich between March and October 1978. Examination of these isolates for resistance to 6 standard antimicrobials revealed that 17 (9.4%) strains were resistant to the tetracyclines, 2 strains to sulphamethoxazole/trimethoprim and 1 strain to both tetracycline and chloramphenicol. All strains were highly sensitive to benzylpenicillin, cephalothin and erythromycin. Serotyping of the pneumococci was done by the capsular quellung reaction. The prevalent serotypes in the entire collection of strains were Nos. 6, 23, 19, 3, 9, 14 and 7. The prevalent serotypes of strains isolated from blood, cerebrospinal fluid, pus, and bronchial secretions were Nos. 4, 8, 7, 14, 9, 3, 19 and 6. Vaccination with PneumovaxTM, a vaccine containing 14 capsular antigens, should provide protection against 75% of pneumococci identified as true pathogens in this study. Pneumococci are rather rarely isolated in our laboratories. For this reason, and because the strains isolated are still sensitive to antibiotics in conventional use, mass vaccination of the population in Switzerland is not recommended. Vaccination should be carried out in certain high risk groups of patients.

Ampicillin↗
PubMed1979

Pyruvate carboxylase activities in red blood cells and liver of chicks and their dependency on biotin status. First results with activation assays..

Pyruvate carboxylase activities of erythrocytes and liver preparations and their in vitro stimulation by biotin were used for the determination of the biotin status of chicks. Reasonable stability of the enzyme in erythrocytes was achieved when storing the erythrocytes deep-frozen in a glycerol-containing medium. Results of the activation assays in erythrocytes and liver are compared with biotin levels in feed, plasma and liver. The pyruvate carboxylase activation assay appears to be a useful tool for assessing the biotin status of chicks.

Animals↗
PubMed1978

[Determination of reduced and oxidised glutathione in wheat flours and doughs (author's transl)].

A quantitative method for the analysis of reduced (GSH) and oxidised (GSSG) glutathione in cereals has been developed. The steps are: Extraction of the flour or dough and carboxymethylation of GSH, gel filtration on Sephadex G-50, chromatography on Dowex 50 WX8 and after basic cleavage determination of the separated GSSG with 5,5'-dithiobis(2-nitrobenzoic acid), separation of carboxymethylated GSH on Dowex 1X8 and determination with 2,4,6-trinitrobenzenesulfonic acid. When analysing for the amount of GSH and GSSG in flours of three varieties of wheat the former ranged from 0.27 to 0.46 mumol/g and the latter from 0.26 to 0.38 mumol/g. After kneading for 5 min to a dough the GSH disappeared with a corresponding increase in GSSG.

Chromatography↗
PubMed1977

Behaviour of glibenclamide on repeated administration to diabetic patients.

Six maturity onset diabetic patients took glibenclamide 5 mg by mouth, every morning 10 min before a standard breakfast. Serum levels of immunoreactive glibenclamide, glucose and immunoreactive insulin were measured repeatedly on the first and 15th days of treatment. Measured glibenclamide blood levels were in close agreement with an analogue computer simulation of data obtained from healthy volunteers: there was no accumulation of drug in the blood, but there was strong evidence for the existence of a slowly equilibrating "deep" compartment. Considerable insulin release and correction of the breakfast-induced hyperglycaemia were observed immediately after administration of the drug, as well as 5 h later, at lunch time. The clinical significance of blood levels of glibenclamide, as well as the correlation of pharmacokinetics with pharmacodynamics, are discussed in the light of these results.

Administration, Oral↗