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Biomedical subjects

F Walker

Publications and source records attributed to F Walker.

At least 127 records · Page 7Linked to original sources
PubMed1983

The distribution of amyloid P component in normal human cervix.

The distribution of amyloid P component in normal human adult cervix was studied using fluorescent immunohistochemical techniques on frozen sections. Amyloid P component is associated with elastic fibres which are particularly concentrated in a sub-epithelial plexus in the ectocervix. This plexus does not extend into the endocervix but terminates at, or just caudal to, the squamocolumnar junction. Amyloid P component was not demonstrated in any of the epithelial basement membranes.

Amyloid↗
PubMed1983

Nephrotic syndrome in Hodgkins disease.

A case of nephrotic syndrome due to minimal lesion glomerulonephritis associated with Hodgkins disease is described. The course of the nephrotic syndrome was relapsing, preceeding the development of lymphoma by eighteen months. Treatment of this nephrotic syndrome with repeated courses of Prednisone and Cyclophosphamide resulted only in partial improvement of his proteinuria. However, complete absence of proteinuria only occurred with successful therapy of Hodgkins disease.

Child↗
PubMed1982

The distribution of amyloid P component in normal human skin.

The distribution of amyloid P component in normal human adult skin was studied using fluorescent immunohistochemical techniques on frozen sections. Amyloid P component is associated with elastic fibres of all sizes, and is present in the basement membrane of sweat gland ducts. It is not demonstrable in the basement membrane at the epidermo-dermal junction or in the secretory portion of the sweat glands. In the latter site there is however a spiral, fibrillar, elastic plexus closely related to the basement membrane.

Adult↗
PubMed1981

Intestinal calcium transport: effect of cimetidine.

Recently cimetidine (Tagamet), a widely used drug for peptic ulcer disease, was found to decrease serum levels of calcium and immunoreactive parathyroid hormone in patients with hyperparathyroidism. Since parathyroid hormone action is closely related to calcium homeostasis, we studied the effect of cimetidine on intestinal calcium transport. An in vivo perfusion technique was used for the study of net transport and lumen to mucosa flux of 45calcium. Our results indicate a significant decrease in net calcium transport and lumen to mucosa flux of 45calcium in the rats injected with cimetidine, compared to control rats. Direct addition of cimetidine to the perfusion solution did not alter transport rates significantly. The mechanism by which cimetidine affects calcium transport may be secondary to its effect on the release of parathyroid hormone from the parathyroid gland or an effect on vitamin D metabolism.

Animals↗
PubMed1981

Autoantibody to nerve tissue in a patient with a peripheral neuropathy and an IgG paraprotein.

The antibody activity of a benign IgG lambda paraprotein to nerve tissue in a case of peripheral neuropathy has been investigated using immunohistochemical methods on tyrpsin-treated, formalin-fixed, paraffin-embedded tissue. IgG lambda was found in th sural nerve biopsy of the patient. Specific binding of the purified IgG lambda paraprotein and its isolated F(ab')2 fragment to homologous nerve and brain tissue was demonstrated. Similar activity was not demonstrable on fresh frozen cryostat sections. The results suggest that tests for autoantibodies to nerve tissue in neuropathological disorders should not be confined to fresh frozen tissue substrates.

Autoantibodies↗