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Biomedical subjects

F W Bora

Publications and source records attributed to F W Bora.

At least 19 recordsLinked to original sources

Neural injuries associated with supracondylar fractures of the humerus in children.

A retrospective review of displaced extension-type supracondylar fractures of the humerus in 101 children who were seen consecutively revealed eighteen associated neural injuries in thirteen children. Nine of the neural injuries in eight patients spontaneously resolved at a mean of 2.5 months (range, 1.5 to five months) after injury. The remaining nine lesions in five patients were explored at a mean of 7.5 months (range, five to fourteen months) after injury, because clinical and electromyographic studies showed no return of function. Neurolysis was performed on eight of the nerves that were explored (in five patients), and the remaining radial nerve was found to be completely lacerated and needed nerve-grafting. The length of follow-up after neurolysis averaged twenty-five months (range, thirteen to forty-four months). All five patients had functional recovery, as documented by range-of-motion, grip-strength and lateral pinch-strength, and von Frey and two-point-discrimination sensory testing. The patient who had had nerve-grafting never recovered neural function, and tendon transfers were needed. We concluded that observation and supportive therapy is the preferred initial approach for children who have a neural injury associated with a closed, displaced supracondylar fracture of the humerus. However, if there is no clinical or electromyographic evidence of return of neural function at five months after injury, exploration and neurolysis should be performed. If the nerve is in continuity, the prognosis after neurolysis is excellent.

Adolescent

Kienböck's disease in a patient with Crohn's enteritis treated with corticosteroids.

In a patient with Crohn's enteritis treated with oral corticosteroids simultaneous Kienböck's disease and femoral head osteonecrosis developed 2 years after the administration of corticosteroids. The patient had no history of trauma or any other risk factor known to be associated with Kienböck's disease. This case suggests that corticosteroid administration may be an additional factor in the multifactorial causes of Kienböck's disease.

Adrenal Cortex Hormones

Prosthetic nerve grafts: a resorbable tube as an alternative to autogenous nerve grafting.

The use of a prosthetic nerve graft, composed of a resorbable polyorthoester tube, as an alternative to free autogenous nerve grafting for the treatment of a gap in a peripheral nerve was studied, with a cat sciatic nerve as the model. The results demonstrate that regeneration will occur through a resorbable tube spanning a 1.5 cm gap and reinnervate end organ muscle. In those muscles showing evidence of reinnervation, nerve regeneration through the tubes as assayed by electrophysiologic examination demonstrated no difference compared with autogenous nerve grafts, with the exception that the initial rate of regeneration was delayed by 4 to 6 weeks.

Animals

Compression neuropathies.

Nerve compression, frequently from entrapment at specific anatomic locations, is a common clinical entity, especially in patients with predisposing occupations or with certain medical disorders. It should be pointed out that a nerve can be compressed at more than one level. Early recognition and treatment are the most effective means of preventing long-lasting disability, since, despite the capacity for regeneration bestowed on the peripheral nervous system, functions lost as a result of denervation are never fully restored.

Animals

Joint physiology, cartilage metabolism, and the etiology of osteoarthritis.

Articular cartilage is hypocellular, avascular, aneural, and alymphatic. Nutrition derives predominantly from the synovial fluid. The cartilage matrix is hyperhydrated. Water represents 80 per cent of the total weight. The water is very important in joint lubrication and wear resistance. The dry weight consists mainly of proteoglycan and type II collagen. Osteoarthritis is not the result of a diminution in metabolic activity but is a very active catabolic process. Matrix synthesis and cell replication proceed at greater rates in damaged than in normal cartilage. Lysosomal enzymes that degrade cartilage are released. Proteoglycan content diminishes in proportion to the disease severity. Despite the heightened synthetic activity, the chondrocyte's capacity is eventually exceeded by the rate of matrix degradation and the cartilage becomes eroded. A multitude of hypotheses have been suggested to explain the etiopathogenesis of osteoarthritis. These hypotheses fall into two categories: those that point to excessive stresses imposed upon normal tissue and those that emphasize the inadequacy of the chondrocyte response. The factors that initiate the process are not fully known. Trauma, aging, joint laxity, diet, hormones, crystal deposition, bone microfractures, and immunologic factors have all been implicated.

Animals

Peripheral nerve grafts: the relationship of axonal growth cone and biomechanical properties.

Cat sciatic nerves containing 2 and 4 cm nerve grafts were subjected to tensile testing with the finding that a significant decrease in force at failure occurs at the distal suture line at a time after surgery that is graft length dependent. Tritiated labeling of regenerating axons and qualitative electromyography demonstrated that this effect was unrelated to the leading edge of the axonal growth cone, but temporally related to the functional reinnervation of denervated muscle.

Animals

Sarcoid flexor tenosynovitis of the finger: a case report.

A case report of flexor tenosynovitis of the right ring finger in a 27-year-old black woman leading to the diagnosis of sarcoidosis is presented. Sarcoidosis of a flexor tendon sheath is rare. Flexor tenosynovectomy provided material for histologic diagnosis and increased the function of the hand.

Adult

Electrical stimulation applied to bone and nerve injuries in the upper extremity.

In conclusion, electrical stimulation of bone has advanced from the laboratory to clinical reality. Despite the lack of good double-blind clinical studies, it is impossible to ignore the excellent results reported from numerous multicenter trials. Doubts and controversies will and should continue. Electrical stimulation has a definite place in the treatment of scaphoid nonunion as well as other failures of osteogenic biology in the upper extremity. The future may realize the enormous potential of electrical stimulation in areas of nerve repair, wound healings, or osteoporosis. The hand surgeon may soon be operating in the age of biophysics where he or she can charge by the kilowatt hour. Yet one should not become a mere technician, but understand the basic science of what one is doing and, above all, maintain a balanced and critical approach.

Arm Injuries

Wrist arthroscope.

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Arthroscopes

Osteoid osteoma of the carpal bones.

Three cases of osteoid osteoma of the carpal bones are described, with a review of the literature. The scaphoid is the carpal bone involved most frequently. Typically the lesions are painful and respond to aspirin. Roentgenologic finding of the central area of lucency surrounded by sclerotic bone often is diagnostic. Block excision with bone grafting is an acceptable method of treatment.

Adult

A comparison of epineurial, perineurial and epiperineurial methods of nerve suture.

An experimental study was designed to compare the effectiveness of epineurial, perineurial, and combined epineurial and perineurial suture after laceration of the sciatic nerve in rabbits by measuring biochemical determinations in the distal stump of the nerve after both immediate and delayed repairs. Relatively more myelin was found in the immediate epineurial group, which suggests that nerve regeneration was most rapid in this group. Additional experiments are needed to evaluate end-organ reinnervation which is another criterion for evaluating the best method of nerve suture in clinical situations.

Animals

Neuroma scar formation in rats following peripheral nerve transection.

Utilizing a sciatic nerve-transection model in rats, we studied the collagen content of normal control nerves, the long-term collagen accummulation in the distal stump of the transected nerve, the content of collagen of the posterior tibial nerve distal to the transection, and the myofibrosis of the gastrocnemius muscle. The distal stump of the sciatic nerve accumulated significant amounts of collagen with time but the posterior tibial nerve at a distance from the site of transection showed no progressive collagen accumulation. The histologically evident myofibrosis of the denervated gastrocnemius muscle was shown to be the result of a selective loss of muscle elements and not of an accumulation of collagen. cis-Hydroxyproline, a proline analogue, limited neuroma formation following neurorrhaphy. The findings suggest that the results of delayed repair of nerves should not be impaired by intraneural scarring if enough of the transected nerve beyond the point of intraneural scar formation is resected.

Animals

A study of nerve regeneration and neuroma formation after nerve suture by various techniques.

The effectiveness of epineurial, perineurial, and a combined epiperineurial methods of nerve suture in the severed sciatic nerve of rabbits was studied by biochemical assay of the collagen just distal to the neuroma and the collagen and myelin of the posterior tibial nerve. Repairs were done both immediately after severance and in a separate group 3 weeks later. More collagen was found near the neuroma in the immediate epineurial group, but 60 per cent of the normal myelin was found in the posterior tibial nerve after the immediate epineural suture compared to 28.3 per cent in the immediate perineurial group.

Animals

Gliding function following flexor-tendon injury. A biomechanical study of rat tendon function.

Gliding function of flexor tendons one hour to eight weeks after a standard injury was studied in rat digits by determining terminal force of flexion, tendon excursion, and work of flexion using a tensile testing machine. A rapid decrease in gliding occurred within hours of injury, indicating that the postoperative hematoma and edema restrict gliding long before collagenous adhesions are synthesized. The improvement in gliding function with time implies that fibrous adhesions can be remodeled. Surgical methods and therapeutic agents, therefore, should be directed toward limiting early tissue injury and seeking ways to enhance the late remodeling of fibrous peritendinous adhesions along functional lines.

Animals

cis-hydroxyproline limits work necessary to flex a digit after tendon injury.

Present surgical procedures for the repair of tendon injury are complicated by formation of peritendinous collagenous adhesions which restrict tendon gliding. Several sensitive biomechanical tests have been developed to quantitate peritendinous restriction of gliding. Using these tests it was found that cis-hydroxyproline significantly limits net collagen accumulation following tendon injury in a rat model and decreases the adhesive restraints to tendon gliding. cis-Hydroxyproline and other proline analoques offer a method for specifically preventing excessive collagen formation.

Animals