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Biomedical subjects

F V DeFeudis

Publications and source records attributed to F V DeFeudis.

At least 127 records · Page 7Linked to original sources
PubMed1977

Glycine-receptors in the vertebrate central nervous system.

Evidence for the existence of glycine-receptors in the vertebrate central nervous system (CNS) has been reviewed and analyzed. Biochemical studies have supported iontophoretic findings that such receptors exist in several regions of the CNS. Subcellular studies on the displacement of 3H-strychnine binding by glycine and on the effects of strychnine on 3H-glycine binding have revealed that strychnine does not interact directly with glycine-receptors, lending support to studies performed in situ. Approaches toward glycine-receptors remain limited due to the inavailability of a specific glycine-antagonist.

Binding Sites↗
PubMed1975

Effects of d-amphetamine on the incorporation of carbon atoms of D-glucose into the brains of differentially-housed mice.

Mice were housed either individually ("isolated") or in groups of 20-25 ("aggregated") for 5-9 weeks or for 22 weeks. A decreased incorporation of radioactivity into brain from subcutaneously-administered U-14C-D-glucose occurred in "isolated" mice as compared to grouped animals. Amphetamine, administered before labelled glucose, produced a dose-dependent decrease of radioactivity which was selective to the brains of the "isolated" mice. The data support the correlation between isolation-induced changes in behavior and central metabolic pathways and indicate further that these changes may be altered by administration of psycho-active agents.

Animals↗
PubMed1975

Binding of gamma-aminobutyric acid and taurine to synaptosomal fractions of regions of the feline CNS.

The "binding" of 3H-gamma-aminobutyric acid (3H-GABA) and 14C-taurine (7 X 10(-5) M) to synaptosomal fractions of the feline CNS was studied using differential centrifugation and double-isotope methods. Of the regions examined, the "binding" of GABA (in nmole/mg protein) occurred to the greatest extent, in cerebral cortex, olfactory bulb, and colliculi and, to a lesser extent, in caudate nucleus, corona radiata, and fornix. Distribution ratios revealed that GABA binding was greater in the cerebral cortex than in caudate nucleus, brain stem, spinal cord, and white matter regions. The binding of taurine (in nmole/mg protein) was lowest in cerebral cortex and highest in brain stem and spinal gray regions. Distribution ratios for taurine indicated that its accumulation was similar in all CNS regions studied, except for slightly higher values for cerebellar cortex and fornix. These results indicated that preferential binding of both GABA and taurine exists among regions of the feline CNS.

Aminobutyrates↗