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Biomedical subjects

F V DeFeudis

Publications and source records attributed to F V DeFeudis.

At least 109 records · Page 6Linked to original sources
PubMed1978

Vertebrate GABA receptors.

Physiologic-pharmacologic studies in vivo and with tissue cultures have revealed that synaptic GABA receptors exist in the vertebrate CNS. The GABA antagonist, bicuculline, can be used to detect synaptic GABA receptors in both the presence and absence of Na+, even though GABA binding to cerebral subcellular fractions occurs mainly to transport (uptake) receptors in the presence of Na+.

Animals↗
PubMed1977

'Binding' of glycine and gamma-aminobutyric acid to synaptosomal fractions of 6 regions of the feline brain; effects of strychnine.

GABA (6 X 10(-6) M) binding to synaptosome-enriched fractions of cat CNS exhibited a clear rostro-caudal gradient, whereas glycine (6 X 10(-6) M) binding was greatest to particles of cerebellar cortex, and this was followed by medulla approximately equal to caudate nucleus larger than or equal to cerebral cortex larger than or equal to pons larger than corona radiata. Strychnine-SO4 (10(-3) or 10(-4) M) inhibited the binding of GABA and glycine in all brain regions studied; at 10(-5) M this drug inhibited the binding of both GABA and glycine only to particles of the cerebral cortex.

Aminobutyrates↗