Search PubMed⌕ Search

Biomedical subjects

F Thompson

Publications and source records attributed to F Thompson.

48 records · Page 3Linked to original sources
PubMed1981

Diet as a coadjuvant for development of antibiotic-associated diarrhea in hamsters (Mesocricetus auratus).

During a study of the effects of nutrition on experimental tumors in hamsters, fatal diarrhea developed. To determine the role of diet in this condition and the relationship between diet and antibiotics, two diets were used, ground commercial diet and a purified diet. Two antibiotics were used, neomycin sulfate and vancomycin. Diarrhea was evident soon after the animals were given the combination of purified diet and neomycin sulfate. Vancomycin initially acted as a suppressor of diarrhea, but hamsters fed the purified diet developed diarrhea after the drug was discontinued. None of the animals fed ground commercial diet treated with neomycin sulfate developed diarrhea. Clostridium difficile was isolated from most of the sick animals; all of the isolates of Clostridium difficile were toxigenic except one. No significant differences were seen among the Clostridium difficile isolated from different animals. Clostridium sporogenes and Clostridium tertium also were isolated from some of the animals.

9,10-Dimethyl-1,2-benzanthracene↗
PubMed1974

Increasing rural Head Start children's consumption of middle-class meals.

Rural black, economically impoverished Head Start children, whose normal diets were deficient in nutritional requirements, were not consuming the nutritional breakfasts of, to them, unfamiliar foods provided by the county school system. This study investigated a positive simple method to increase the amount of food consumed and thereby ensure proper nutrition. Teachers dispensed sugar-coated cereal and small candies paired with praise contingent on eating behaviors and rewarded children who finished the entire meal with additional treats and praise. Substantial increases were produced in the proportion of meals consumed and in the number of children observed engaged in eating behaviors. These simple traditional behavioral procedures are readily available for any staff working with economically impoverished children as one method of increasing their sampling and consumption of unfamiliar nutritious foods.

Black or African American↗
PubMedDate not supplied

Examination of clonal variants from human malignant melanoma studied by chromosome banding analysis.

Multiple metastatic melanoma lesions from three patients were cytogenetically characterized in order to assess the degree of intra-patient karyotypic heterogeneity. A total of 20 specimens were analysed: 12 samples from patient No. 1, five samples from patient No. 2, and three samples from patient No. 3. Sufficient mitoses were obtained to perform detailed analysis in 19/20 specimens following short-term culture. The modal chromosome number of all three cases was near-diploid, with all samples demonstrating multiple structural abnormalities. Abnormalities shared by all three patients were alterations of chromosomes 1 and 8. Other structural abnormalities common to two of the three patients involved chromosomes 6, 7, 9 and 10. Minor intra-tumour karyotypic variation was detected in all three cases. However, the majority of clonal alterations were retained in all metastatic lesions, clearly indicating the karyotypically stable and clonal nature of this neoplasm.

Adult↗