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Biomedical subjects

F Schmidt

Publications and source records attributed to F Schmidt.

At least 199 records · Page 11Linked to original sources
PubMed1980

[The influence of acemetacin and indometacin on gastrointestinal blood loss in normal volunteers and rheumatic patients (author's transl)].

In a clinical trial on 12 healthy volunteers total gastrointestinal blood loss was measured with 51Cr-labelled erythrocytes. This double-blind cross-over study showed a highly significant difference (p < 0.001) between indometacin and [1-(p-chlorobenzoyl)-5-methoxy-2-methylindol-3-acetoxy[acetic acid (acemetacin, TV 1322, Rantudil¿) after oral application of 200 mg acemetacin, 200 mg indometacin per day and placebo for a week. Average total blood loss within seven days was 12.4 ml after indometacin, 4.5 ml after acemetacin and 5.0 ml after placebo. In a clinical trial on 16 rheumatic patients taking commercial non-steroidal antiinflammatory drugs over a long time total gastrointestinal blood loss was determined likewise. After a preceding wash-out period the blood loss due to acemetacin (240 mg daily) and indometacin (200 mg daily) for seven days was compared. There was a highly significant difference (p < 0.001) between both drugs. Total weekly blood loss was measured as 13.8 ml due to the treatment with indometacin and 6.5 ml due to acemetacin. During the wash-out period blood loss was detected as 6.0 ml weekly. There was no difference between the results of both trials. These clinical trials on 35 patients and volunteers do not give any indication that the new antiinflammatory drug acemetacin may cause mucosal lesions in the gastrointestinal tract evedenced by blood loss.

Adult↗
PubMed1979

[Health damage by means of forced smoking].

Forced smoking (= passive smoking) is not only a molestation but a real health risk for nonsmokers. The reasons for this are given in detail by a survey of results of the world literature. The main reasons are: In tobacco smoke are more than 40 cancerogenic substances which show a clear summative effect in contrast to other poisons. Avoidable cancerogens therefore must be eliminated from our environment wherever it is possible. There is no reason to make an exception with tobacco smoke. Special attention is to be paid to more than a dozen of cancerogenic nitrosamines in tobacco smoke. The content of nitrosamines in sidestream-smoke is up to fifty times higher than in the main stream of the tobacco smoke. Tobacco smoke therefore is the most important source of nitrosamines in our environment at all. The cancerogenic effect of passive smoking is secured in animal experiments unobjectionably. Passive smoking is the most important cause of bronchitis and pneumonia in early childhood and favours inflammations of the respiratory tract in older children and in animal experiments, etc.

Air Pollution↗
PubMed1979

[Comparison of the value of ERCP, angiography and scintigraphy in pancreatic diseases].

The endoscopic retrograde cholangiopancreaticography, angiography and scintigraphy have a different value in the diagnostics of chronic pancreatitis and carcinoma of the pancreas. The scintigraphy of pancreas has the lowest value. It should not alone be the basis for making the diagnosis or planning the treatment. In chronic pancreatitis the endoscopic retrograde cholangiopancreaticography has precedence of angiography. The chronic pancreatitis may angiographically be recognised only in the late phase. However, the angiography can give valuable references to the planning of the operation. At a suspicion of the pancreas malignoma the endoscopic retrograde cholangiopancreaticography and the angiography have nearly the same value in the plan of diagnostics and they both should be performed.

Angiography↗
PubMed1979

Tyramine kinetics and metabolism in cirrhosis.

Hypertyraminemia is common in hepatic cirrhosis and correlates in severity with encephalopathy. The mechanism of cirrhotic hypertyraminemia has not been established. The alternative possibilities are increased production from tyrosine and impaired degradation by monoamine oxidase. This investigation determined the pharmacokinetics of tyramine after an intravenous bolus injections of [3H]-tyramine (180--200 muCi 12 Ci/mmol sp act) in 13 cirrhotics and 9 controls. In normals, [3H]tyramine levels initially declined rapidly (alpha-phase) followed by a slower decline (beta-phase) with an average t 1/2 of 20.8 min. Average normal metabolic clearance rate and production rate were 13.2 liters/min and 15.4 microgram/min, respectively. In cirrhotic patients, the plasma disappearance curve for [3H]tyramine was qualitatively similar to that of the control subjects with no apparent different in beta-t 1/2 (17.2 min). The hypertyraminemia of cirrhosis resulted primarily from overproduction of tyramine, as the production rate (32.0 microgram/min) in these patients was significantly greater (P less than 0.05) than in controls, whereas the metabolic clearance rate remained normal (average 12.2 liters/min). A difference in ratio of tyramine metabolic products was noted as well. Cirrhotics had a high ratio of plasma 4-hydroxyphenylethanol:4-hydroxyphenylacetic acid (60:40 vs. 30:70) as compared with normals. Although the tyramine clearance rates are similar in normals and cirrhotics, different mechanisms may be responsible for catabolism.

Adult↗
PubMed1979

Characterization of a naturally occurring R plasmid in Salmonella isangi conferring unusually high resistance to ampicillin.

A strain of Salmonella isangi was isolated from HUMANA milk, used a baby food in Bulgarian hospitals. It harbours two stable plasmids, distinguishable by their molecular weight of 21 Mdal for the transfer factor (rRB 1) and 9,3 Mdal for R-factor rRB 2, confering resistance to ampicillin, cephalothin, streptomycin and sulfonamides. Both plasmids are maintained in different copy numbers per chromosome genome equivalent, 8 copies for rRB 1 and 158 copies for rRB 2, associated with an unusual high level of resistance to ampicillin (MIC 65 mg/ml).

Ampicillin↗
PubMed1978

[Value of lymphography within the framework of complex diagnosis of fever of unknown origin].

After comprehensive diagnostics on account of antibiotic-resistant subfebrile temperatures under suspicion of a lymphogranulomatosis a lymphography was performed in a 49-year-old patient. The lymphographic findings are discussed in detail. Since these findings differential-diagnostically allow a tuberculosis of the lymph nodes, a tuberculostatic therapy is performed. 6 months later the patient has an improved general condition and may again work in this former profession.

Diagnosis, Differential↗